Cannabis Compound Database: Showing Compound Card for Thymidine 5'-triphosphate (CDB005248)

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Record Information

Version

1.0

Created at

2020-04-17 19:24:10 UTC

Updated at

2020-11-18 16:39:36 UTC

CannabisDB ID

CDB005248

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Thymidine 5'-triphosphate

Description

Thymidine 5'-triphosphate, also known as TTP or DTHD5'ppp, belongs to the class of organic compounds known as pyrimidine 2'-deoxyribonucleoside triphosphates. These are pyrimidine nucleotides with a triphosphate group linked to the ribose moiety lacking a hydroxyl group at position 2. Thymidine 5'-triphosphate or Thymidine 5'-triphosphate is one of the four nucleoside triphosphates that make up DNA. Thymidine 5'-triphosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). Thymidine 5'-triphosphate exists in all living species, ranging from bacteria to humans. Outside of the human body, Thymidine 5'-triphosphate has been detected, but not quantified in, several different foods, such as elliott's blueberries, mamey sapotes, sesames, alliums, and sweet oranges. This could make thymidine 5'-triphosphate a potential biomarker for the consumption of these foods. Thymidine 5'-triphosphate is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
2'-Deoxythymidine triphosphate	ChEBI
5'-TTP	ChEBI
Deoxy-TTP	ChEBI
Deoxythymidine 5'-triphosphate	ChEBI
Deoxythymidine triphosphate	ChEBI
DTHD5'ppp	ChEBI
PPPDT	ChEBI
THYMIDINE-5'-triphosphATE	ChEBI
TTP	ChEBI
2'-Deoxythymidine triphosphoric acid	Generator
Deoxythymidine 5'-triphosphoric acid	Generator
Deoxythymidine triphosphoric acid	Generator
THYMIDINE-5'-triphosphoric acid	Generator
Thymidine 5'-triphosphoric acid	Generator
2'-Deoxythymidine 5'-triphosphate	HMDB
5-Methyl-dUTP	HMDB
dTTP	HMDB
Thymidine mono(tetrahydrogen triphosphate)	HMDB
Thymidine triphosphate	HMDB
Thymidine 5'-triphosphate, magnesium salt	HMDB
Thymidine 5'-triphosphate, trisodium salt	HMDB
2'-Deoxythymidine-5'-triphosphate	HMDB
Thymidine 5'-triphosphate, p''-(32)p-labeled	HMDB
2’-Deoxythymidine 5’-triphosphate	HMDB
2’-Deoxythymidine triphosphate	HMDB
5’-TTP	HMDB
Deoxythymidine 5’-triphosphate	HMDB
Thymidine 5'-triphosphate	HMDB
Thymidine 5’-triphosphate	HMDB

Chemical Formula

C₁₀H₁₇N₂O₁₄P₃

Average Molecular Weight

482.17

Monoisotopic Molecular Weight

481.9893

IUPAC Name

{[hydroxy({[hydroxy({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy})phosphoryl]oxy})phosphoryl]oxy}phosphonic acid

Traditional Name

dTTP

CAS Registry Number

365-08-2

SMILES

CC1=CN([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)NC1=O

InChI Identifier

InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/t6-,7+,8+/m0/s1

InChI Key

NHVNXKFIZYSCEB-XLPZGREQSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as pyrimidine 2'-deoxyribonucleoside triphosphates. These are pyrimidine nucleotides with a triphosphate group linked to the ribose moiety lacking a hydroxyl group at position 2.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

Pyrimidine nucleotides

Sub Class

Pyrimidine deoxyribonucleotides

Direct Parent

Pyrimidine 2'-deoxyribonucleoside triphosphates

Alternative Parents

Substituents

Pyrimidine 2'-deoxyribonucleoside triphosphate
Pyrimidone
Monoalkyl phosphate
Hydropyrimidine
Organic phosphoric acid derivative
Phosphoric acid ester
Pyrimidine
Alkyl phosphate
Heteroaromatic compound
Vinylogous amide
Tetrahydrofuran
Lactam
Secondary alcohol
Urea
Oxacycle
Azacycle
Organoheterocyclic compound
Hydrocarbon derivative
Organic oxide
Organooxygen compound
Organonitrogen compound
Organopnictogen compound
Organic oxygen compound
Alcohol
Organic nitrogen compound
Aromatic heteromonocyclic compound

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

pyrimidine 2'-deoxyribonucleoside 5'-triphosphate (CHEBI:18077 )
thymidine phosphate (CHEBI:18077 )
Deoxyribonucleotides (C00459 )

Ontology

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Plant:

Animal

Biological location:

Subcellular:

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-0.39	ALOGPS
logP	-2.1	ChemAxon
logS	-1.7	ALOGPS
pKa (Strongest Acidic)	0.9	ChemAxon
pKa (Strongest Basic)	-3.2	ChemAxon
Physiological Charge	-3	ChemAxon
Hydrogen Acceptor Count	11	ChemAxon
Hydrogen Donor Count	6	ChemAxon
Polar Surface Area	238.69 Å²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	88.03 m³·mol⁻¹	ChemAxon
Polarizability	36.6 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	Thymidine 5'-triphosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0002-9742300000-c721ba5109dede8a518b	Spectrum
Predicted GC-MS	Thymidine 5'-triphosphate, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-00dl-9305110000-bbc51754a929afc4eb54	Spectrum
Predicted GC-MS	Thymidine 5'-triphosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-001i-0000900000-d176c8e8a9bdb2d457e5	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-001i-0000900000-d176c8e8a9bdb2d457e5	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-00di-0900000000-970154df2a1ed9a84a2f	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 15V, negative	splash10-001i-0000900000-50c7a1492866ca00359d	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 18V, negative	splash10-001i-0200900000-dda4f6996cabd8db242f	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 20V, negative	splash10-053r-0602900000-0390bef6ad193f2b5004	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 23V, negative	splash10-0a59-0902600000-2f2a5a489951a9c68992	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 26V, negative	splash10-0a4i-0912200000-1d8c5b170f87fa6f2c9b	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 34V, negative	splash10-0a4i-1921100000-93f84465717aa16d3f7c	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 41V, negative	splash10-0a4i-2920000000-6d1131e45ff20126cf41	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 50V, negative	splash10-0a6r-5910000000-2a9eb44864392efb37c3	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 59V, negative	splash10-056r-9700000000-71a33ac9eaf4e714b558	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 73V, negative	splash10-004i-9200000000-0667d2c3d019b5ca17bc	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 33V, negative	splash10-001i-0209200000-ed0d460f9e1d08011f06	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 33V, negative	splash10-004i-9000000000-5ef060d5ec4b80c35c1a	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 33V, negative	splash10-0a4i-0190000000-e8bf71168cfd7e675dca	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 33V, negative	splash10-001r-0019000000-d84a6f61ca04e6970204	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 16V, negative	splash10-001i-0009000000-6f966eb3b101b9fadfbe	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 18V, negative	splash10-001i-0019000000-f7153b7fadabb2f7f79f	2020-07-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-004i-0900000000-9c496d7377af5eb651b2	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-004i-2901000000-99a48a5d17f022d6494c	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-004i-4900000000-889ecd9966747af96efe	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-053i-1410900000-cc4f8db45f53046b5380	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-057r-9870100000-6cf02bd6b66f7b822525	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9100000000-cde9ec4f970230e9f180	2016-09-12	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Pyrimidine Metabolism
Beta Ureidopropionase Deficiency		Not Available
UMP Synthase Deficiency (Orotic Aciduria)		Not Available
Dihydropyrimidinase Deficiency		Not Available
MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ectonucleoside triphosphate diphosphohydrolase 1	ENTPD1	10q24	P49961	details
Soluble calcium-activated nucleotidase 1	CANT1	17q25.3	Q8WVQ1	details
Ectonucleoside triphosphate diphosphohydrolase 3	ENTPD3	3p21.3	O75355	details
Uridine-cytidine kinase 1	UCK1	9q34.13	Q9HA47	details
Nucleoside diphosphate kinase, mitochondrial	NME4	16p13.3	O00746	details
Nucleoside diphosphate kinase A	NME1	17q21.3	P15531	details
Nucleoside diphosphate kinase 7	NME7	1q24	Q9Y5B8	details
Nucleoside diphosphate kinase B	NME2	17q21.3	P22392	details
Nucleoside diphosphate kinase 3	NME3	16q13.3	Q13232	details
Nucleoside diphosphate kinase 6	NME6	3p21	O75414	details
Inosine triphosphate pyrophosphatase	ITPA	20p	Q9BY32	details
DNA-directed RNA polymerase II subunit RPB2	POLR2B	4q12	P30876	details
DNA-directed RNA polymerase II subunit RPB1	POLR2A	17p13.1	P24928	details
DNA-directed RNA polymerase, mitochondrial	POLRMT	19p13.3	O00411	details
DNA-directed RNA polymerase I subunit RPA2	POLR1B	2q13	Q9H9Y6	details
DNA-directed RNA polymerase III subunit RPC2	POLR3B	12q23.3	Q9NW08	details
DNA polymerase beta	POLB	8p11.2	P06746	details
DNA polymerase alpha catalytic subunit	POLA1	Xp22.1-p21.3	P09884	details
DNA polymerase delta subunit 3	POLD3	11q14	Q15054	details
DNA polymerase lambda	POLL	10q23	Q9UGP5	details
DNA polymerase epsilon subunit 4	POLE4	2p12	Q9NR33	details
DNA polymerase eta	POLH	6p21.1	Q9Y253	details
DNA polymerase delta catalytic subunit	POLD1	19q13.3	P28340	details
DNA polymerase zeta catalytic subunit	REV3L	6q21	O60673	details
DNA polymerase epsilon catalytic subunit A	POLE	12q24.3	Q07864	details
DNA-directed DNA/RNA polymerase mu	POLM	7p13	Q9NP87	details
DNA polymerase kappa	POLK	5q13	Q9UBT6	details
DNA polymerase epsilon subunit 3	POLE3	9q33	Q9NRF9	details
DNA polymerase subunit gamma-1	POLG	15q25	P54098	details
DNA polymerase iota	POLI	18q21.1	Q9UNA4	details
DNA polymerase epsilon subunit 2	POLE2	14q21-q22	P56282	details
Uridine-cytidine kinase 2	UCK2	1q23	Q9BZX2	details
Uridine-cytidine kinase-like 1	UCKL1	20q13.33	Q9NWZ5	details
Ectonucleoside triphosphate diphosphohydrolase 8	ENTPD8	9q34.3	Q5MY95	details
Putative nucleoside diphosphate kinase	NME2P1	12q24.31	O60361	details
DNA-directed RNA polymerase III subunit RPC1	POLR3A	10q22-q23	O14802	details
DNA-directed RNA polymerase I subunit RPA1	POLR1A	2p11.2	O95602	details
Myb-binding protein 1A	MYBBP1A	17p13.3	Q9BQG0	details
DNA polymerase theta	POLQ	3q13.33	O75417	details
DNA polymerase delta subunit 2	POLD2	7p13	P49005	details
Nucleoside diphosphate kinase homolog 5	NME5		P56597	details
DNA primase small subunit	PRIM1		P49642	details
DNA primase large subunit	PRIM2		P49643	details

Transporters

Not Available

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Soluble calcium-activated nucleotidase 1	CANT1	17q25.3	Q8WVQ1	details
Nucleoside diphosphate kinase, mitochondrial	NME4	16p13.3	O00746	details
Nucleoside diphosphate kinase 7	NME7	1q24	Q9Y5B8	details
Nucleoside diphosphate kinase B	NME2	17q21.3	P22392	details
Nucleoside diphosphate kinase 3	NME3	16q13.3	Q13232	details
Nucleoside diphosphate kinase 6	NME6	3p21	O75414	details
Inosine triphosphate pyrophosphatase	ITPA	20p	Q9BY32	details
DNA-directed RNA polymerase II subunit RPB2	POLR2B	4q12	P30876	details
DNA-directed RNA polymerase II subunit RPB1	POLR2A	17p13.1	P24928	details
DNA-directed RNA polymerase I subunit RPA2	POLR1B	2q13	Q9H9Y6	details
DNA-directed RNA polymerase III subunit RPC2	POLR3B	12q23.3	Q9NW08	details
DNA polymerase beta	POLB	8p11.2	P06746	details
DNA polymerase alpha catalytic subunit	POLA1	Xp22.1-p21.3	P09884	details
DNA polymerase lambda	POLL	10q23	Q9UGP5	details
DNA polymerase eta	POLH	6p21.1	Q9Y253	details
DNA polymerase delta catalytic subunit	POLD1	19q13.3	P28340	details
DNA polymerase zeta catalytic subunit	REV3L	6q21	O60673	details
DNA polymerase epsilon catalytic subunit A	POLE	12q24.3	Q07864	details
DNA-directed DNA/RNA polymerase mu	POLM	7p13	Q9NP87	details
DNA polymerase kappa	POLK	5q13	Q9UBT6	details
DNA polymerase iota	POLI	18q21.1	Q9UNA4	details
DNA-directed RNA polymerase III subunit RPC1	POLR3A	10q22-q23	O14802	details
DNA-directed RNA polymerase I subunit RPA1	POLR1A	2p11.2	O95602	details
DNA primase small subunit	PRIM1		P49642	details
DNA primase large subunit	PRIM2		P49643	details

Receptors

Not Available

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Nucleoside diphosphate kinase B	NME2	17q21.3	P22392	details
DNA-directed RNA polymerase II subunit RPB2	POLR2B	4q12	P30876	details
DNA-directed RNA polymerase II subunit RPB1	POLR2A	17p13.1	P24928	details
DNA-directed RNA polymerase, mitochondrial	POLRMT	19p13.3	O00411	details
DNA-directed RNA polymerase I subunit RPA2	POLR1B	2q13	Q9H9Y6	details
DNA-directed RNA polymerase III subunit RPC2	POLR3B	12q23.3	Q9NW08	details
DNA polymerase alpha catalytic subunit	POLA1	Xp22.1-p21.3	P09884	details
DNA polymerase epsilon subunit 4	POLE4	2p12	Q9NR33	details
DNA polymerase delta catalytic subunit	POLD1	19q13.3	P28340	details
DNA polymerase epsilon catalytic subunit A	POLE	12q24.3	Q07864	details
DNA polymerase epsilon subunit 3	POLE3	9q33	Q9NRF9	details
DNA polymerase epsilon subunit 2	POLE2	14q21-q22	P56282	details
DNA-directed RNA polymerase III subunit RPC1	POLR3A	10q22-q23	O14802	details
DNA-directed RNA polymerase I subunit RPA1	POLR1A	2p11.2	O95602	details
Myb-binding protein 1A	MYBBP1A	17p13.3	Q9BQG0	details
DNA polymerase delta subunit 2	POLD2	7p13	P49005	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0001342

DrugBank ID

DB02452

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

Deoxythymidine_Triphosphate

METLIN ID

Not Available

PubChem Compound

64968

PDB ID

Not Available

ChEBI ID

18077

References

General References

Not Available

Only showing the first 10 proteins. There are 84 proteins in total.

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Enzymes

Enzyme Details

1. Ectonucleoside triphosphate diphosphohydrolase 1

General function:: Involved in hydrolase activity
Specific function:: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Gene Name:: ENTPD1
Uniprot ID:: P49961
Molecular weight:: 58706.0

Enzyme Details

2. Soluble calcium-activated nucleotidase 1

General function:: Involved in calcium ion binding
Specific function:: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
Gene Name:: CANT1
Uniprot ID:: Q8WVQ1
Molecular weight:: 44839.24

Enzyme Details

3. Ectonucleoside triphosphate diphosphohydrolase 3

General function:: Involved in hydrolase activity
Specific function:: Has a threefold preference for the hydrolysis of ATP over ADP.
Gene Name:: ENTPD3
Uniprot ID:: O75355
Molecular weight:: 59104.76

Enzyme Details

4. Uridine-cytidine kinase 1

General function:: Involved in ATP binding
Specific function:: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
Gene Name:: UCK1
Uniprot ID:: Q9HA47
Molecular weight:: 22760.43

Enzyme Details

5. Nucleoside diphosphate kinase, mitochondrial

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity).
Gene Name:: NME4
Uniprot ID:: O00746
Molecular weight:: 20658.45

Enzyme Details

6. Nucleoside diphosphate kinase A

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.
Gene Name:: NME1
Uniprot ID:: P15531
Molecular weight:: 17148.635

Enzyme Details

7. Nucleoside diphosphate kinase 7

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Gene Name:: NME7
Uniprot ID:: Q9Y5B8
Molecular weight:: 42491.365

Enzyme Details

8. Nucleoside diphosphate kinase B

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.
Gene Name:: NME2
Uniprot ID:: P22392
Molecular weight:: 30136.92

Enzyme Details

9. Nucleoside diphosphate kinase 3

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.
Gene Name:: NME3
Uniprot ID:: Q13232
Molecular weight:: 19014.85

Enzyme Details

10. Nucleoside diphosphate kinase 6

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.
Gene Name:: NME6
Uniprot ID:: O75414
Molecular weight:: 22002.965

Only showing the first 10 proteins. There are 84 proteins in total.

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Showing Compound Card for Thymidine 5'-triphosphate (CDB005248)

Structure for CDB005248 (Thymidine 5'-triphosphate)

Enzymes