| Identification |
|---|
| HMDB Protein ID
| CDBP00905 |
| Secondary Accession Numbers
| Not Available |
| Name
| DNA polymerase epsilon subunit 3 |
| Description
| Not Available |
| Synonyms
|
- Arsenic-transactivated protein
- AsTP
- CHRAC-17
- Chromatin accessibility complex 17 kDa protein
- DNA polymerase II subunit 3
- DNA polymerase epsilon subunit p17
- HuCHRAC17
|
| Gene Name
| POLE3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sequence-specific DNA binding |
| Specific Function
| Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1.
|
| GO Classification
|
| Biological Process |
| DNA replication |
| histone H3 acetylation |
| Cellular Component |
| epsilon DNA polymerase complex |
| Ada2/Gcn5/Ada3 transcription activator complex |
| Component |
| cell part |
| intracellular |
| Function |
| binding |
| nucleic acid binding |
| dna binding |
| sequence-specific dna binding |
| Molecular Function |
| sequence-specific DNA binding |
| DNA-directed DNA polymerase activity |
|
| Cellular Location
|
- Nucleus (Potential)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | DNA replication | Not Available |  | | Base excision repair | Not Available |  | | HTLV-I infection | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9q33 |
| SNPs
| POLE3 |
| Gene Sequence
|
>444 bp
ATGGCGGAGAGGCCCGAGGACCTAAACCTGCCCAATGCCGTGATCACCAGGATCATCAAG
GAGGCGCTCCCGGACGGTGTCAACATCTCCAAGGAGGCCCGGAGCGCCATCTCCCGCGCC
GCCAGCGTCTTCGTGCTGTACGCCACATCCTGTGCTAACAACTTTGCAATGAAAGGAAAG
CGGAAGACGCTGAATGCCAGTGATGTGCTCTCAGCCATGGAAGAGATGGAGTTCCAGCGG
TTCGTTACCCCATTGAAAGAAGCTCTGGAAGCATATAGGCGGGAGCAGAAAGGCAAGAAG
GAGGCCTCAGAGCAAAAGAAGAAGGACAAAGACAAAAAAACAGACTCGGAAGAGCAAGAC
AAGAGCAGGGATGAGGACAATGATGAAGACGAAGAAAGGCTGGAAGAAGAAGAACAGAAT
GAAGAGGAAGAAGTAGACAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 147 |
| Molecular Weight
| 16859.4 |
| Theoretical pI
| 4.737 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>DNA polymerase epsilon subunit 3
MAERPEDLNLPNAVITRIIKEALPDGVNISKEARSAISRAASVFVLYATSCANNFAMKGK
RKTLNASDVLSAMEEMEFQRFVTPLKEALEAYRREQKGKKEASEQKKKDKDKKTDSEEQD
KSRDEDNDEDEERLEEEEQNEEEEVDN
|
| External Links |
|---|
| GenBank ID Protein
| 8100806 |
| UniProtKB/Swiss-Prot ID
| Q9NRF9 |
| UniProtKB/Swiss-Prot Entry Name
| DPOE3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF226077 |
| GeneCard ID
| POLE3 |
| GenAtlas ID
| POLE3 |
| HGNC ID
| HGNC:13546 |
| References |
|---|
| General References
| Not Available |