| Identification |
|---|
| HMDB Protein ID
| CDBP00102 |
| Secondary Accession Numbers
| Not Available |
| Name
| Uridine-cytidine kinase 1 |
| Description
| Not Available |
| Synonyms
|
- Cytidine monophosphokinase 1
- UCK 1
- Uridine monophosphokinase 1
|
| Gene Name
| UCK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
|
| GO Classification
|
| Biological Process |
| pyrimidine nucleoside salvage |
| pyrimidine nucleobase metabolic process |
| CTP salvage |
| UMP salvage |
| UMP biosynthetic process |
| Cellular Component |
| cytosol |
| Function |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| phosphotransferase activity, alcohol group as acceptor |
| Molecular Function |
| phosphotransferase activity, alcohol group as acceptor |
| ATP binding |
| nucleoside kinase activity |
| uridine kinase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | UMP biosynthesis via salvage pathway | Not Available | Not Available | | CTP biosynthesis via salvage pathway | Not Available | Not Available | | Drug metabolism - other enzymes | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9q34.13 |
| SNPs
| UCK1 |
| Gene Sequence
|
>834 bp
ATGGCTTCGGCGGGAGGCGAAGACTGCGAGAGCCCCGCGCCGGAGGCCGACCGTCCGCAC
CAGCGGCCCTTCCTGATAGGGGTGAGCGGCGGCACTGCCAGCGGGAAGTCGACCGTGTGT
GAGAAGATCATGGAGTTGCTGGGACAGAACGAGGTGGAACAGCGGCAGCGGAAGGTGGTC
ATCCTGAGCCAGGACAGGTTCTACAAGGTCCTGACGGCAGAGCAGAAGGCCAAGGCCTTG
AAAGGACAGTACAATTTTGACCATCCAGATGCCTTTGATAATGATTTGATGCACAGGACT
CTGAAGAACATCGTGGAGGGCAAAACGGTGGAGGTGCCGACCTATGATTTTGTGACACAC
TCAAGGTTACCAGAGACCACGGTGGTCTACCCTGCGGACGTGGTTCTGTTTGAGGGCATC
TTGGTGTTCTACAGCCAGGAGATCCGGGACATGTTCCACCTGCGCCTCTTCGTGGACACC
GACTCCGACGTCAGGCTGTCTCGAAGAGTTCTCCGGGACGTGCGCCGAGGGAGGGACCTG
GAGCAGATTCTGACGCAGTACACCACCTTCGTGAAGCCGGCCTTCGAGGAGTTCTGCCTG
CCGACAAAGAAGTATGCCGATGTGATCATCCCGCGAGGAGTGGACAATATGGTTGCCATC
AACCTGATCGTGCAGCACATCCAGGACATTCTGAATGGTGACATCTGCAAATGGCACCGA
GGAGGGTCCAATGGGCGGAGCTACAAGCGGACCTTTTCTGAGCCAGGGGACCACCCTGGG
ATGCTGACCTCTGGCAAACGGTCACATTTGGAGTCCAGCAGCAGACCCCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 277 |
| Molecular Weight
| 22760.43 |
| Theoretical pI
| 6.275 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Uridine-cytidine kinase 1
MASAGGEDCESPAPEADRPHQRPFLIGVSGGTASGKSTVCEKIMELLGQNEVEQRQRKVV
ILSQDRFYKVLTAEQKAKALKGQYNFDHPDAFDNDLMHRTLKNIVEGKTVEVPTYDFVTH
SRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSRRVLRDVRRGRDL
EQILTQYTTFVKPAFEEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDILNGDICKWHR
GGSNGRSYKRTFSEPGDHPGMLTSGKRSHLESSSRPH
|
| External Links |
|---|
| GenBank ID Protein
| 13899253 |
| UniProtKB/Swiss-Prot ID
| Q9HA47 |
| UniProtKB/Swiss-Prot Entry Name
| UCK1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_031432.2 |
| GeneCard ID
| UCK1 |
| GenAtlas ID
| UCK1 |
| HGNC ID
| HGNC:14859 |
| References |
|---|
| General References
| Not Available |