Cannabis Compound Database: Showing Protein Nucleoside diphosphate kinase 6 (CDBP00110)

Identification Biological properties Gene properties Protein properties External links References XML Show 13 compounds

Identification

HMDB Protein ID

CDBP00110

Secondary Accession Numbers

Not Available

Name

Nucleoside diphosphate kinase 6

Description

Not Available

Synonyms

IPIA-alpha
Inhibitor of p53-induced apoptosis-alpha
NDK 6
NDP kinase 6
nm23-H6

Gene Name

NME6

Protein Type

Enzyme

Biological Properties

General Function

Involved in nucleoside diphosphate kinase activity

Specific Function

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.

GO Classification

Biological Process
apoptotic process
negative regulation of apoptotic process
CTP biosynthetic process
GTP biosynthetic process
UTP biosynthetic process
negative regulation of mitosis
nucleoside triphosphate biosynthetic process
negative regulation of cell growth
Cellular Component
mitochondrion
Function
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
nucleoside diphosphate kinase activity
binding
catalytic activity
phosphotransferase activity, phosphate group as acceptor
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleoside binding
Molecular Function
metal ion binding
ATP binding
nucleoside diphosphate kinase activity
Process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
ctp biosynthetic process
pyrimidine nucleotide metabolic process
pyrimidine nucleoside triphosphate biosynthetic process
pyrimidine nucleotide biosynthetic process
pyrimidine ribonucleoside triphosphate biosynthetic process
utp biosynthetic process
purine nucleotide metabolic process
purine nucleotide biosynthetic process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
gtp biosynthetic process

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
Purine Metabolism
Adenosine Deaminase Deficiency		Not Available
Adenylosuccinate Lyase Deficiency		Not Available
Gout or Kelley-Seegmiller Syndrome		Not Available
Lesch-Nyhan Syndrome (LNS)		Not Available

Gene Properties

Chromosome Location

Locus

3p21

SNPs

NME6

Gene Sequence

>561 bp
ATGGCCTCAATCTTGCGAAGCCCTCAGGCTCTCCAGCTCACTCTAGCCCTGATCAAGCCT
GACGCAGTCGCCCATCCACTGATTCTGGAGGCTGTTCATCAGCAGATTCTAAGCAACAAG
TTCCTGATTGTACGAATGAGAGAACTACTGTGGAGAAAGGAAGATTGCCAGAGGTTTTAC
CGAGAGCATGAAGGGCGTTTTTTCTATCAGAGGCTGGTGGAGTTCATGGCCAGCGGGCCA
ATCCGAGCCTACATCCTTGCCCACAAGGATGCCATCCAGCTCTGGAGGACGCTCATGGGA
CCCACCAGAGTGTTCCGAGCACGCCATGTGGCCCCAGATTCTATCCGTGGGAGTTTCGGC
CTCACTGACACCCGCAACACCACCCATGGTTCGGACTCTGTGGTTTCAGCCAGCAGAGAG
ATTGCAGCCTTCTTCCCTGACTTCAGTGAACAGCGCTGGTATGAGGAGGAAGAGCCCCAG
TTGCGCTGTGGCCCTGTGTGCTATAGCCCAGAGGGAGGTGTCCACTATGTAGCTGGAACA
GGAGGCCTAGGACCAGCCTGA

Protein Properties

Number of Residues

186

Molecular Weight

22002.965

Theoretical pI

7.96

Pfam Domain Function

NDK (PF00334 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Nucleoside diphosphate kinase 6
MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRMRELLWRKEDCQRFY
REHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMGPTRVFRARHVAPDSIRGSFG
LTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQLRCGPVCYSPEGGVHYVAGT
GGLGPA

External Links

GenBank ID Protein

3228530

UniProtKB/Swiss-Prot ID

O75414

UniProtKB/Swiss-Prot Entry Name

NDK6_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF051941

GeneCard ID