Showing Protein Nucleoside diphosphate kinase B (CDBP00108)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 13 compounds
Identification
HMDB Protein ID CDBP00108
Secondary Accession Numbers Not Available
Name Nucleoside diphosphate kinase B
Description Not Available
Synonyms
  1. C-myc purine-binding transcription factor PUF
  2. NDK B
  3. NDP kinase B
  4. nm23-H2
  5. Histidine protein kinase NDKB
Gene Name NME2
Protein Type Enzyme
Biological Properties
General Function Involved in nucleoside diphosphate kinase activity
Specific Function Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.
GO Classification
Biological Process
lactation
transcription, DNA-dependent
response to cAMP
negative regulation of apoptotic process
nucleobase-containing small molecule interconversion
cell adhesion
response to drug
positive regulation of keratinocyte differentiation
CTP biosynthetic process
GTP biosynthetic process
UTP biosynthetic process
nucleoside triphosphate biosynthetic process
negative regulation of myeloid leukocyte differentiation
positive regulation of epithelial cell proliferation
Cellular Component
cytosol
centrosome
mitochondrion
ruffle
perinuclear region of cytoplasm
nucleus
lamellipodium
intermediate filament
Function
transferase activity, transferring phosphorus-containing groups
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
nucleoside diphosphate kinase activity
binding
catalytic activity
phosphotransferase activity, phosphate group as acceptor
transferase activity
Molecular Function
metal ion binding
sequence-specific DNA binding transcription factor activity
ATP binding
nucleoside diphosphate kinase activity
protein histidine kinase activity
DNA binding
Process
purine nucleotide metabolic process
purine nucleotide biosynthetic process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
gtp biosynthetic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
ctp biosynthetic process
pyrimidine nucleoside triphosphate biosynthetic process
pyrimidine nucleotide metabolic process
pyrimidine ribonucleoside triphosphate biosynthetic process
pyrimidine nucleotide biosynthetic process
utp biosynthetic process
Cellular Location
  1. Nucleus
  2. Cytoplasm
Pathways
Gene Properties
Chromosome Location 17
Locus 17q21.3
SNPs NME2
Gene Sequence 
>459 bp
ATGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTG
GTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTC
CTCCGGGCCTCTGAAGAACACCTGAAGCAGCACTACATTGACCTGAAAGACCGACCATTC
TTCCCTGGGCTGGTGAAGTACATGAACTCAGGGCCGGTTGTGGCCATGGTCTGGGAGGGG
CTGAACGTGGTGAAGACAGGCCGAGTGATGCTTGGGGAGACCAATCCAGCAGATTCAAAG
CCAGGCACCATTCGTGGGGACTTCTGCATTCAGGTTGGCAGGAACATCATTCATGGCAGT
GATTCAGTAAAAAGTGCTGAAAAAGAAATCAGCCTATGGTTTAAGCCTGAAGAACTGGTT
GACTACAAGTCTTGTGCTCATGACTGGGTCTATGAATAA
Protein Properties
Number of Residues 152
Molecular Weight 30136.92
Theoretical pI 8.93
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Nucleoside diphosphate kinase B
MANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPF
FPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGS
DSVKSAEKEISLWFKPEELVDYKSCAHDWVYE
GenBank ID Protein 4467843
UniProtKB/Swiss-Prot ID P22392
UniProtKB/Swiss-Prot Entry Name NDKB_HUMAN
PDB IDs
GenBank Gene ID X58965
GeneCard ID NME2
GenAtlas ID NME2
HGNC ID HGNC:7850
References
General References Not Available