Cannabis Compound Database: Showing Protein Soluble calcium-activated nucleotidase 1 (CDBP00082)

Identification Biological properties Gene properties Protein properties External links References XML Show 17 compounds

Identification

HMDB Protein ID

CDBP00082

Secondary Accession Numbers

Not Available

Name

Soluble calcium-activated nucleotidase 1

Description

Not Available

Synonyms

Apyrase homolog
Putative MAPK-activating protein PM09
Putative NF-kappa-B-activating protein 107
SCAN-1

Gene Name

CANT1

Protein Type

Enzyme

Biological Properties

General Function

Involved in calcium ion binding

Specific Function

Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.

GO Classification

Biological Process
positive regulation of I-kappaB kinase/NF-kappaB cascade
proteoglycan biosynthetic process
Cellular Component
endoplasmic reticulum membrane
Golgi cisterna membrane
integral to membrane
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
hydrolase activity
calcium ion binding
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
Molecular Function
signal transducer activity
calcium ion binding
uridine-diphosphatase activity

Cellular Location

Endoplasmic reticulum membrane
Single-pass type II membrane protein
Single-pass type II membrane protein
Golgi apparatus
Golgi stack membrane

Pathways

Name	SMPDB/Pathwhiz	KEGG
Lactose Synthesis		Not Available
Congenital disorder of glycosylation CDG-IId		Not Available
GLUT-1 deficiency syndrome		Not Available
Pyrimidine Metabolism
Beta Ureidopropionase Deficiency		Not Available

Gene Properties

Chromosome Location

Locus

17q25.3

SNPs

CANT1

Gene Sequence

>1206 bp
ATGCCCGTGCAGCTGTCTGAGCACCCGGAATGGAATGAGTCTATGCACTCCCTCCGGATC
AGTGTGGGGGGCCTTCCTGTGCTGGCGTCCATGACCAAGGCCGCGGACCCCCGCTTCCGC
CCCCGCTGGAAGGTGATCCTGACGTTCTTTGTGGGTGCTGCCATCCTCTGGCTGCTCTGC
TCCCACCGCCCGGCCCCCGGCAGGCCCCCCACCCACAATGCACACAACTGGAGGCTCGGC
CAGGCGCCCGCCAACTGGTACAATGACACCTACCCCCTGTCTCCCCCACAAAGGACACCG
GCTGGGATTCGGTATCGAATCGCAGTTATCGCAGACCTGGACACAGAGTCAAGGGCCCAA
GAGGAAAACACCTGGTTCAGTTACCTGAAAAAGGGCTACCTGACCCTGTCAGACAGTGGG
GACAAGGTGGCCGTGGAATGGGACAAAGACCATGGGGTCCTGGAGTCCCACCTGGCGGAG
AAGGGGAGAGGCATGGAGCTATCCGACCTGATTGTTTTCAATGGGAAACTCTACTCCGTG
GATGACCGGACGGGGGTCGTCTACCAGATCGAAGGCAGCAAAGCCGTGCCCTGGGTGATT
CTGTCCGACGGCGACGGCACCGTGGAGAAAGGCTTCAAGGCCGAATGGCTGGCAGTGAAG
GACGAGCGTCTGTACGTGGGCGGCCTGGGCAAGGAGTGGACGACCACTACGGGTGATGTG
GTGAACGAGAACCCGGAGTGGGTGAAGGTGGTGGGCTACAAGGGCAGCGTGGACCACGAG
AACTGGGTGTCCAACTACAACGCCCTGCGGGCTGCTGCCGGCATCCAGCCGCCAGGCTAC
CTCATCCATGAGTCTGCCTGCTGGAGTGACACGCTGCAGCGCTGGTTCTTCCTGCCGCGC
CGCGCCAGCCAGGAGCGCTACAGCGAGAAGGACGACGAGCGCAAGGGCGCCAACCTGCTG
CTGAGCGCCTCCCCTGACTTCGGCGACATCGCTGTGAGCCACGTCGGGGCGGTGGTCCCC
ACTCACGGCTTCTCGTCCTTCAAGTTCATCCCCAACACCGACGACCAGATCATTGTGGCC
CTCAAATCCGAGGAGGACAGCGGCAGAGTCGCCTCCTACATCATGGCCTTCACGCTGGAC
GGGCGCTTCCTGTTGCCGGAGACCAAGATCGGAAGCGTGAAATACGAAGGCATCGAGTTC
ATTTAA

Protein Properties

Number of Residues

401

Molecular Weight

44839.24

Theoretical pI

6.082

Pfam Domain Function

Apyrase (PF06079 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Soluble calcium-activated nucleotidase 1
MPVQLSEHPEWNESMHSLRISVGGLPVLASMTKAADPRFRPRWKVILTFFVGAAILWLLC
SHRPAPGRPPTHNAHNWRLGQAPANWYNDTYPLSPPQRTPAGIRYRIAVIADLDTESRAQ
EENTWFSYLKKGYLTLSDSGDKVAVEWDKDHGVLESHLAEKGRGMELSDLIVFNGKLYSV
DDRTGVVYQIEGSKAVPWVILSDGDGTVEKGFKAEWLAVKDERLYVGGLGKEWTTTTGDV
VNENPEWVKVVGYKGSVDHENWVSNYNALRAAAGIQPPGYLIHESACWSDTLQRWFFLPR
RASQERYSEKDDERKGANLLLSASPDFGDIAVSHVGAVVPTHGFSSFKFIPNTDDQIIVA
LKSEEDSGRVASYIMAFTLDGRFLLPETKIGSVKYEGIEFI

External Links

GenBank ID Protein

229577440

UniProtKB/Swiss-Prot ID

Q8WVQ1

UniProtKB/Swiss-Prot Entry Name

CANT1_HUMAN

PDB IDs