Cannabis Compound Database: Showing Compound Card for L-Glutamine (CDB004853)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (25)transporters (4) Show 38 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:43:33 UTC

Updated at

2022-12-13 23:36:24 UTC

CannabisDB ID

CDB004853

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

L-Glutamine

Description

L-Glutamine, also known as levoglutamide or Q, belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom. An optically active form of glutamine having L-configuration. L-Glutamine is a drug which is used for nutritional supplementation, also for treating dietary shortage or imbalance. used to reduce the acute complications of sickle cell disease in adult and pediatric patients 5 years of age and older [fda label]. L-Glutamine is a very strong basic compound (based on its pKa). L-Glutamine exists in all living species, ranging from bacteria to humans. phenylacetyl-CoA and L-glutamine can be converted into phenylacetylglutamine; which is mediated by the enzyme glycine N-acyltransferase. In humans, L-glutamine is involved in phenylacetate metabolism. Outside of the human body, L-Glutamine is found, on average, in the highest concentration within a few different foods, such as wheats, broccoli, and red beetroots and in a lower concentration in cucumbers, garden onions, and nanking cherries. L-Glutamine has also been detected, but not quantified in, several different foods, such as rambutans, common salsifies, greenthread tea, common walnuts, and celery stalks. This could make L-glutamine a potential biomarker for the consumption of these foods. L-Glutamine is a potentially toxic compound. L-Glutamine, with regard to humans, has been found to be associated with several diseases such as schizophrenia, eosinophilic esophagitis, phosphoenolpyruvate carboxykinase deficiency 1, cytosolic, and crohn's disease; L-glutamine has also been linked to the inborn metabolic disorder fumarase deficiency. L-Glutamine is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(2S)-2,5-Diamino-5-oxopentanoic acid	ChEBI
(2S)-2-Amino-4-carbamoylbutanoic acid	ChEBI
(S)-2,5-Diamino-5-oxopentanoic acid	ChEBI
Glutamic acid 5-amide	ChEBI
Glutamic acid amide	ChEBI
GLUTAMINE	ChEBI
L-(+)-Glutamine	ChEBI
L-2-Aminoglutaramic acid	ChEBI
L-Glutamic acid gamma-amide	ChEBI
L-Glutamin	ChEBI
L-Glutaminsaeure-5-amid	ChEBI
Levoglutamide	ChEBI
Q	ChEBI
Endari	Kegg
Nutrestore	Kegg
(2S)-2,5-Diamino-5-oxopentanoate	Generator
(2S)-2-Amino-4-carbamoylbutanoate	Generator
(S)-2,5-Diamino-5-oxopentanoate	Generator
Glutamate 5-amide	Generator
Glutamate amide	Generator
L-2-Aminoglutaramate	Generator
L-Glutamate g-amide	Generator
L-Glutamate gamma-amide	Generator
L-Glutamate γ-amide	Generator
L-Glutamic acid g-amide	Generator
L-Glutamic acid γ-amide	Generator
2-Aminoglutaramic acid	HMDB
Cebrogen	HMDB
gamma-Glutamine	HMDB
Glavamin	HMDB
Glumin	HMDB
L-2-Aminoglutaramidic acid	HMDB
L-Glutamic acid 5-amide	HMDB
L-Glutamid	HMDB
L-Glutamide	HMDB
Levoglutamid	HMDB
Levoglutamida	HMDB
Levoglutamidum	HMDB
Levoglutamina	HMDB
Polyglutamine	HMDB
Stimulina	HMDB
D-Glutamine	HMDB
D Glutamine	HMDB
L Glutamine	HMDB

Chemical Formula

C₅H₁₀N₂O₃

Average Molecular Weight

146.14

Monoisotopic Molecular Weight

146.0691

IUPAC Name

(2S)-2-amino-4-carbamoylbutanoic acid

Traditional Name

L-glutamine

CAS Registry Number

56-85-9

SMILES

N[C@@H](CCC(N)=O)C(O)=O

InChI Identifier

InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1

InChI Key

ZDXPYRJPNDTMRX-VKHMYHEASA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

L-alpha-amino acids

Alternative Parents

Substituents

L-alpha-amino acid
Fatty acid
Amino acid
Carboximidic acid
Carboximidic acid derivative
Carboxylic acid
Monocarboxylic acid or derivatives
Amine
Hydrocarbon derivative
Primary amine
Organooxygen compound
Organonitrogen compound
Organic oxide
Primary aliphatic amine
Organopnictogen compound
Organic oxygen compound
Organic nitrogen compound
Carbonyl group
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

proteinogenic amino acid (CHEBI:18050 )
L-alpha-amino acid (CHEBI:18050 )
glutamine (CHEBI:18050 )
glutamine family amino acid (CHEBI:18050 )
Common amino acids (C00064 )

Ontology

Leukemia

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Synthetic:

Personal care product

Biological:

Animal

Plant:

Biological location:

Role

Industrial application:

Personal care products

Food and nutrition:

Nutritional supplement

Pharmaceutical industry:

Pharmaceutical

Biological role:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	185 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	41.3 mg/mL	YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP	-3.64	CHMELIK,J ET AL. (1991)

Predicted Properties

Property	Value	Source
logP	-3.3	ALOGPS
logP	-4	ChemAxon
logS	-0.17	ALOGPS
pKa (Strongest Acidic)	2.15	ChemAxon
pKa (Strongest Basic)	9.31	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	106.41 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	33.11 m³·mol⁻¹	ChemAxon
Polarizability	13.87 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
EI-MS	Mass Spectrum (Electron Ionization)	splash10-001i-9000000000-bc4e294b8a3fd8c5abce	2014-09-20	View Spectrum
GC-MS	L-Glutamine, 3 TMS, GC-MS Spectrum	splash10-0a4i-0910000000-adb283bb40327f705680	Spectrum
GC-MS	L-Glutamine, 3 TMS, GC-MS Spectrum	splash10-0a4i-0910000000-134e80840320dadf6ad1	Spectrum
GC-MS	L-Glutamine, 3 TMS, GC-MS Spectrum	splash10-05fr-7910000000-89f87d4acc18299244f5	Spectrum
GC-MS	L-Glutamine, 2 TMS, GC-MS Spectrum	splash10-0a4i-0900000000-952a471cad5e5ead0a7e	Spectrum
GC-MS	L-Glutamine, 4 TMS, GC-MS Spectrum	splash10-004i-1961000000-94183211889cfe72d4ff	Spectrum
GC-MS	L-Glutamine, 3 TMS, GC-MS Spectrum	splash10-0a4i-1920000000-6505cd814f3707a0feba	Spectrum
GC-MS	L-Glutamine, 4 TMS, GC-MS Spectrum	splash10-004i-0692000000-9788416fdefb051b9586	Spectrum
GC-MS	L-Glutamine, non-derivatized, GC-MS Spectrum	splash10-0a4i-0910000000-adb283bb40327f705680	Spectrum
GC-MS	L-Glutamine, non-derivatized, GC-MS Spectrum	splash10-0a4i-0910000000-134e80840320dadf6ad1	Spectrum
GC-MS	L-Glutamine, non-derivatized, GC-MS Spectrum	splash10-00dj-4921200000-5446333d9aa592da8a07	Spectrum
GC-MS	L-Glutamine, non-derivatized, GC-MS Spectrum	splash10-05fr-7910000000-89f87d4acc18299244f5	Spectrum
GC-MS	L-Glutamine, non-derivatized, GC-MS Spectrum	splash10-0a4i-0900000000-952a471cad5e5ead0a7e	Spectrum
GC-MS	L-Glutamine, non-derivatized, GC-MS Spectrum	splash10-004i-1961000000-94183211889cfe72d4ff	Spectrum
GC-MS	L-Glutamine, non-derivatized, GC-MS Spectrum	splash10-0a4i-1920000000-6505cd814f3707a0feba	Spectrum
GC-MS	L-Glutamine, non-derivatized, GC-MS Spectrum	splash10-004i-0692000000-9788416fdefb051b9586	Spectrum
GC-MS	L-Glutamine, non-derivatized, GC-MS Spectrum	splash10-0a4i-0910000000-ce2b15fe45c57a30c6bb	Spectrum
GC-MS	L-Glutamine, non-derivatized, GC-MS Spectrum	splash10-0ab9-1900000000-7be5eab1056d2a249ab5	Spectrum
GC-MS	L-Glutamine, non-derivatized, GC-MS Spectrum	splash10-0a4i-0900000000-5dc2d147bea250c7b80e	Spectrum
GC-MS	L-Glutamine, non-derivatized, GC-MS Spectrum	splash10-0fb9-0921000000-5dcbab01982f543f7925	Spectrum
GC-MS	L-Glutamine, non-derivatized, GC-MS Spectrum	splash10-004j-0940000000-102c9a43b5153f06927f	Spectrum
Predicted GC-MS	L-Glutamine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0006-9300000000-716b1947d48f42862cdf	Spectrum
Predicted GC-MS	L-Glutamine, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-00dl-9610000000-bfd7aa529a6e7f62de43	Spectrum
Predicted GC-MS	L-Glutamine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Glutamine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Glutamine, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-0059-3900000000-c8f487d1a561e49327c0	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-001i-9000000000-eee04836e7577e11d0d0	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-0a59-9000000000-54ffbe5be8d7dbede389	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0002-0900000000-79283391c985f8286677	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-9000000000-6afbd5929b6e2371a371	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-d5bd83614703b048228e	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-dc8def340a2655f9a399	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0002-0900000000-47e3e94a4387c53e0bd6	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-9000000000-c1acfa3750a90d81ce15	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-004i-0900000000-93f01bccbc98f18d4b07	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-ce03708ec9ce55cd8952	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0002-0933201000-9339494cebedd9c39135	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-004i-0900000000-64561a4c3590d5994e37	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0002-0900000000-fdcdd7591fb182d804e2	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03dm-0030900000-66314ae704783630947a	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0002-0933100000-8798d2e46a415bb1029a	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-004i-0900000000-dddea137e500a9b364cc	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0002-0900000000-a78f8e4b2d6b37917b21	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0002-0920000000-8c6e1eb7de6f70911080	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-0002-0900000000-fa42fc4bcba608992804	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-004i-2900000000-074610880ea19a417f60	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-059x-9200000000-8b7dae54eb8325667bd7	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-0006-9000000000-e115d9215eea3f0c3629	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-0006-9000000000-55b1ac62eea66274b984	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-001j-0900000000-c9c71895033d66cb2bec	2012-08-31	View Spectrum

NMR

Type	Description	View
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 22.5 MHz, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY 2D NMR Spectrum (experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Pyrimidine Metabolism
Glutamate Metabolism
Transcription/Translation	Not Available	Not Available
Purine Metabolism
Urea Cycle

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2	GFPT2	5q34-q35	O94808	details
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	GFPT1	2p13	Q06210	details
Amidophosphoribosyltransferase	PPAT	4q12	Q06203	details
Kynurenine--oxoglutarate transaminase 1	CCBL1	9q34.11	Q16773	details
Glutamine--tRNA ligase	QARS	3p21.31	P47897	details
Asparagine synthetase [glutamine-hydrolyzing]	ASNS	7q21.3	P08243	details
GMP synthase [glutamine-hydrolyzing]	GMPS	3q24	P49915	details
Protein-glutamine gamma-glutamyltransferase E	TGM3	20q11.2	Q08188	details
Protein-glutamine gamma-glutamyltransferase 2	TGM2	20q12	P21980	details
Glutamine synthetase	GLUL	1q31	P15104	details
Glutaminase liver isoform, mitochondrial	GLS2	12q13	Q9UI32	details
CTP synthase 1	CTPS1	1p34.1	P17812	details
Protein-glutamine gamma-glutamyltransferase 5	TGM5	15q15.2	O43548	details
Glutaminase kidney isoform, mitochondrial	GLS	2q32-q34	O94925	details
Protein-glutamine gamma-glutamyltransferase 4	TGM4	3p22-p21.33	P49221	details
Protein-glutamine gamma-glutamyltransferase K	TGM1	14q11.2	P22735	details
Protein-glutamine gamma-glutamyltransferase 6	TGM6	20p13	O95932	details
Protein-glutamine gamma-glutamyltransferase Z	TGM7	15q15.2	Q96PF1	details
Phosphoribosylformylglycinamidine synthase	PFAS	17p13.1	O15067	details
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112	4q31.3	O75879	details
Glutamine-dependent NAD(+) synthetase	NADSYN1	11q13.4	Q6IA69	details
CTP synthase 2	CTPS2	Xp22	Q9NRF8	details
Glycine N-acyltransferase-like protein 1	GLYATL1	11q12.1	Q969I3	details
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial	QRSL1	6q21	Q9H0R6	details
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial	GATC	12q24.31	O43716	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Neutral amino acid transporter B(0)	SLC1A5	19q13.3	Q15758	details
Large neutral amino acids transporter small subunit 2	SLC7A8	14q11.2	Q9UHI5	details
Sodium-coupled neutral amino acid transporter 3	SLC38A3	3p21.3	Q99624	details
Monocarboxylate transporter 10	SLC16A10	6q21-q22	Q8TF71	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Amidophosphoribosyltransferase	PPAT	4q12	Q06203	details
Protein-glutamine gamma-glutamyltransferase 2	TGM2	20q12	P21980	details
Coagulation factor XIII A chain	F13A1	6p25.3-p24.3	P00488	details
Protein-glutamine gamma-glutamyltransferase 5	TGM5	15q15.2	O43548	details
Protein-glutamine gamma-glutamyltransferase 4	TGM4	3p22-p21.33	P49221	details
Protein-glutamine gamma-glutamyltransferase K	TGM1	14q11.2	P22735	details
Protein-glutamine gamma-glutamyltransferase 6	TGM6	20p13	O95932	details
Protein-glutamine gamma-glutamyltransferase Z	TGM7	15q15.2	Q96PF1	details
CAD protein	CAD	2p22-p21	P27708	details

Receptors

Not Available

Transcriptional Factors

Not Available

Concentrations Data

Cannabis Cultivar	Status	Value	Reference	Details
Alien Dawg	Detected and Quantified	2.158 mg/g dry wt	David S. Wishart,...	details
Gabriola	Detected and Quantified	4.867 mg/g dry wt	David S. Wishart,...	details
Island Honey	Detected and Quantified	4.310 mg/g dry wt	David S. Wishart,...	details
Quadra	Detected and Quantified	0.631 mg/g dry wt	David S. Wishart,...	details
Sensi Star	Detected and Quantified	2.242 mg/g dry wt	David S. Wishart,...	details
Tangerine Dream	Detected and Quantified	5.349 mg/g dry wt	David S. Wishart,...	details

External Links

HMDB ID

HMDB0000641

DrugBank ID

DB00130

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

18050

References

General References

Not Available

Only showing the first 10 proteins. There are 38 proteins in total.

Show All

Enzymes

Enzyme Details

1. Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

General function:: Involved in metabolic process
Specific function:: Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.
Gene Name:: GFPT2
Uniprot ID:: O94808
Molecular weight:: 76929.885

Enzyme Details

2. Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

General function:: Involved in metabolic process
Specific function:: Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.
Gene Name:: GFPT1
Uniprot ID:: Q06210
Molecular weight:: 78805.81

Enzyme Details

3. Amidophosphoribosyltransferase

General function:: Involved in amidophosphoribosyltransferase activity
Specific function:: Not Available
Gene Name:: PPAT
Uniprot ID:: Q06203
Molecular weight:: 57398.52

Enzyme Details

4. Kynurenine--oxoglutarate transaminase 1

General function:: Involved in 1-aminocyclopropane-1-carboxylate synthase activity
Specific function:: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.
Gene Name:: CCBL1
Uniprot ID:: Q16773
Molecular weight:: 47874.765

Enzyme Details

5. Glutamine--tRNA ligase

General function:: Involved in nucleotide binding
Specific function:: Not Available
Gene Name:: QARS
Uniprot ID:: P47897
Molecular weight:: 87797.97

Enzyme Details

6. Asparagine synthetase [glutamine-hydrolyzing]

General function:: Involved in asparagine synthase (glutamine-hydrolyzing) activity
Specific function:: Not Available
Gene Name:: ASNS
Uniprot ID:: P08243
Molecular weight:: 62167.855

Enzyme Details

7. GMP synthase [glutamine-hydrolyzing]

General function:: Involved in catalytic activity
Specific function:: Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.
Gene Name:: GMPS
Uniprot ID:: P49915
Molecular weight:: 76714.79

Enzyme Details

8. Protein-glutamine gamma-glutamyltransferase E

General function:: Involved in protein-glutamine gamma-glutamyltransferase activity
Specific function:: Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.
Gene Name:: TGM3
Uniprot ID:: Q08188
Molecular weight:: 76631.26

Enzyme Details

9. Protein-glutamine gamma-glutamyltransferase 2

General function:: Involved in protein-glutamine gamma-glutamyltransferase activity
Specific function:: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
Gene Name:: TGM2
Uniprot ID:: P21980
Molecular weight:: 77328.21

Enzyme Details

10. Glutamine synthetase

General function:: Involved in glutamate-ammonia ligase activity
Specific function:: This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.
Gene Name:: GLUL
Uniprot ID:: P15104
Molecular weight:: 42064.15

Transporters

Enzyme Details

1. Neutral amino acid transporter B(0)

General function:: Involved in sodium:dicarboxylate symporter activity
Specific function:: Has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. Act as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses
Gene Name:: SLC1A5
Uniprot ID:: Q15758
Molecular weight:: 56597.6

Enzyme Details

2. Large neutral amino acids transporter small subunit 2

General function:: Involved in transport
Specific function:: Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney
Gene Name:: SLC7A8
Uniprot ID:: Q9UHI5
Molecular weight:: 58381.1

Enzyme Details

3. Sodium-coupled neutral amino acid transporter 3

General function:: Amino acid transport and metabolism
Specific function:: Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission
Gene Name:: SLC38A3
Uniprot ID:: Q99624
Molecular weight:: 55772.4

Enzyme Details

4. Monocarboxylate transporter 10

General function:: Involved in transmembrane transport
Specific function:: Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells
Gene Name:: SLC16A10
Uniprot ID:: Q8TF71
Molecular weight:: 55492.1

Only showing the first 10 proteins. There are 38 proteins in total.

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Showing Compound Card for L-Glutamine (CDB004853)

Structure for CDB004853 (L-Glutamine)

Enzymes

Transporters