Cannabis Compound Database: Showing Protein Glutamine synthetase (CDBP00634)

Identification Biological properties Gene properties Protein properties External links References XML Show 6 compounds

Identification

HMDB Protein ID

CDBP00634

Secondary Accession Numbers

Not Available

Name

Glutamine synthetase

Description

Not Available

Synonyms

GS
Glutamate decarboxylase
Glutamate--ammonia ligase

Gene Name

GLUL

Protein Type

Enzyme

Biological Properties

General Function

Involved in glutamate-ammonia ligase activity

Specific Function

This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.

GO Classification

Biological Process
neurotransmitter uptake
response to glucose stimulus
glutamine biosynthetic process
glutamate catabolic process
cellular nitrogen compound metabolic process
cell proliferation
Cellular Component
cytosol
mitochondrion
Function
catalytic activity
ligase activity
acid-ammonia (or amide) ligase activity
ammonia ligase activity
glutamate-ammonia ligase activity
ligase activity, forming carbon-nitrogen bonds
Molecular Function
ATP binding
glutamate-ammonia ligase activity
glutamate decarboxylase activity
Process
nitrogen compound metabolic process
cellular metabolic process
glutamine metabolic process
glutamine family amino acid metabolic process
glutamine biosynthetic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
metabolic process

Cellular Location

Cytoplasm
Mitochondrion

Pathways

Name	SMPDB/Pathwhiz	KEGG
Ammonia Recycling
Alanine, aspartate and glutamate metabolism	Not Available
Glyoxylate and dicarboxylate metabolism	Not Available
Glutamatergic synapse	Not Available
GABAergic synapse	Not Available

Gene Properties

Chromosome Location

Locus

1q31

SNPs

GLUL

Gene Sequence

>1122 bp
ATGACCACCTCAGCAAGTTCCCACTTAAATAAAGGCATCAAGCAGGTGTACATGTCCCTG
CCTCAGGGTGAGAAAGTCCAGGCCATGTATATCTGGATCGATGGTACTGGAGAAGGACTG
CGCTGCAAGACCCGGACCCTGGACAGTGAGCCCAAGTGTGTGGAAGAGTTGCCTGAGTGG
AATTTCGATGGCTCCAGTACTTTACAGTCTGAGGGTTCCAACAGTGACATGTATCTCGTG
CCTGCTGCCATGTTTCGGGACCCCTTCCGTAAGGACCCTAACAAGCTGGTGTTATGTGAA
GTTTTCAAGTACAATCGAAGGCCTGCAGAGACCAATTTGAGGCACACCTGTAAACGGATA
ATGGACATGGTGAGCAACCAGCACCCCTGGTTTGGCATGGAGCAGGAGTATACCCTCATG
GGGACAGATGGGCACCCCTTTGGTTGGCCTTCCAACGGCTTCCCAGGGCCCCAGGGTCCA
TATTACTGTGGTGTGGGAGCAGACAGAGCCTATGGCAGGGACATCGTGGAGGCCCATTAC
CGGGCCTGCTTGTATGCTGGAGTCAAGATTGCGGGGACTAATGCCGAGGTCATGCCTGCC
CAGTGGGAATTTCAGATTGGACCTTGTGAAGGAATCAGCATGGGAGATCATCTCTGGGTG
GCCCGTTTCATCTTGCATCGTGTGTGTGAAGACTTTGGAGTGATAGCAACCTTTGATCCT
AAGCCCATTCCTGGGAACTGGAATGGTGCAGGCTGCCATACCAACTTCAGCACCAAGGCC
ATGCGGGAGGAGAATGGTCTGAAGTACATCGAGGAGGCCATTGAGAAACTAAGCAAGCGG
CACCAGTACCACATCCGTGCCTATGATCCCAAGGGAGGCCTGGACAATGCCCGACGTCTA
ACTGGATTCCATGAAACCTCCAACATCAACGACTTTTCTGGTGGTGTAGCCAATCGTAGC
GCCAGCATACGCATTCCCCGGACTGTTGGCCAGGAGAAGAAGGGTTACTTTGAAGATCGT
CGCCCCTCTGCCAACTGCGACCCCTTTTCGGTGACAGAAGCCCTCATCCGCACGTGTCTT
CTCAATGAAACCGGCGATGAGCCCTTCCAGTACAAAAATTAA

Protein Properties

Number of Residues

373

Molecular Weight

42064.15

Theoretical pI

6.885

Pfam Domain Function

Gln-synt_C (PF00120 )
Gln-synt_N (PF03951 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Glutamine synthetase
MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEW
NFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRI
MDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHY
RACLYAGVKIAGTNAEVMPAQWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDP
KPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRL
TGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCL
LNETGDEPFQYKN

External Links

GenBank ID Protein

31833

UniProtKB/Swiss-Prot ID

P15104

UniProtKB/Swiss-Prot Entry Name

GLNA_HUMAN

PDB IDs