Cannabis Compound Database: Showing Protein Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (CDBP00210)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP00210

Secondary Accession Numbers

Not Available

Name

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

Description

Not Available

Synonyms

D-fructose-6-phosphate amidotransferase 1
GFAT 1
GFAT1
Glutamine:fructose 6 phosphate amidotransferase 1
Hexosephosphate aminotransferase 1
Glutamine:fructose-6-phosphate amidotransferase 1

Gene Name

GFPT1

Protein Type

Enzyme

Biological Properties

General Function

Involved in metabolic process

Specific Function

Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.

GO Classification

Biological Process
glutamine metabolic process
negative regulation of glycogen biosynthetic process
dolichol-linked oligosaccharide biosynthetic process
post-translational protein modification
protein N-linked glycosylation via asparagine
UDP-N-acetylglucosamine biosynthetic process
cellular response to insulin stimulus
response to sucrose stimulus
glucosamine biosynthetic process
carbohydrate biosynthetic process
fructose 6-phosphate metabolic process
energy reserve metabolic process
protein homotetramerization
activation of signaling protein activity involved in unfolded protein response
Cellular Component
cytosol
Component
intracellular part
cytoplasm
intracellular
cell
cell part
Function
binding
catalytic activity
transferase activity
transferase activity, transferring nitrogenous groups
transaminase activity
glutamine-fructose-6-phosphate transaminase (isomerizing) activity
carbohydrate binding
sugar binding
Molecular Function
carbohydrate binding
glutamine-fructose-6-phosphate transaminase (isomerizing) activity
amino acid binding
Process
primary metabolic process
carbohydrate metabolic process
physiological process
metabolism
macromolecule metabolism
carbohydrate biosynthesis
carbohydrate biosynthetic process
macromolecule biosynthesis
carbohydrate metabolism
metabolic process

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
UDP-N-acetyl-alpha-D-glucosamine biosynthesis	Not Available	Not Available
Alanine, aspartate and glutamate metabolism	Not Available
Amino sugar and nucleotide sugar metabolism	Not Available
Amino Sugar Metabolism
Sialuria or French Type Sialuria		Not Available

Gene Properties

Chromosome Location

Locus

2p13

SNPs

GFPT1

Gene Sequence

>2046 bp
ATGTGTGGTATATTTGCTTACTTAAACTACCATGTTCCTCGAACGAGACGAGAAATCCTG
GAGACCCTAATCAAAGGCCTTCAGAGACTGGAGTACAGAGGATATGATTCTGCTGGTGTG
GGATTTGATGGAGGCAATGATAAAGATTGGGAAGCCAATGCCTGCAAAATCCAGCTTATT
AAGAAGAAAGGAAAAGTTAAGGCACTGGATGAAGAAGTTCACAAGCAACAAGATATGGAT
TTGGATATAGAATTTGATGTACACCTTGGAATAGCTCATACCCGTTGGGCAACACATGGA
GAACCCAGTCCTGTCAATAGCCACCCCCAGCGCTCTGATAAAAATAATGAATTTATCGTT
ATTCACAATGGAATCATCACCAACTACAAAGACTTGAAAAAGTTTTTGGAAAGCAAAGGC
TATGACTTCGAATCTGAAACAGACACAGAGACAATTGCCAAGCTCGTTAAGTATATGTAT
GACAATCGGGAAAGTCAAGATACCAGCTTTACTACCTTGGTGGAGAGAGTTATCCAACAA
TTGGAAGGTGCTTTTGCACTTGTGTTTAAAAGTGTTCATTTTCCCGGGCAAGCAGTTGGC
ACAAGGCGAGGTAGCCCTCTGTTGATTGGTGTACGGAGTGAACATAAACTTTCTACTGAT
CACATTCCTATACTCTACAGAACAGGCAAAGACAAGAAAGGAAGCTGCAATCTCTCTCGT
GTGGACAGCACAACCTGCCTTTTCCCGGTGGAAGAAAAAGCAGTGGAGTATTACTTTGCT
TCTGATGCAAGTGCTGTCATAGAACACACCAATCGCGTCATCTTTCTGGAAGATGATGAT
GTTGCAGCAGTAGTGGATGGACGTCTTTCTATCCATCGAATTAAACGAACTGCAGGAGAT
CACCCCGGACGAGCTGTGCAAACACTCCAGATGGAACTCCAGCAGATCATGAAGGGCAAC
TTCAGTTCATTTATGCAGAAGGAAATATTTGAGCAGCCAGAGTCTGTCGTGAACACAATG
AGAGGAAGAGTCAACTTTGATGACTATACTGTGAATTTGGGTGGTTTGAAGGATCACATA
AAGGAGATCCAGAGATGCCGGCGTTTGATTCTTATTGCTTGTGGAACAAGTTACCATGCT
GGTGTAGCAACACGTCAAGTTCTTGAGGAGCTGACTGAGTTGCCTGTGATGGTGGAACTA
GCAAGTGACTTCCTGGACAGAAACACACCAGTCTTTCGAGATGATGTTTGCTTTTTCCTT
AGTCAATCAGGTGAGACAGCAGATACTTTGATGGGTCTTCGTTACTGTAAGGAGAGAGGA
GCTTTAACTGTGGGGATCACAAACACAGTTGGCAGTTCCATATCACGGGAGACAGATTGT
GGAGTTCATATTAATGCTGGTCCTGAGATTGGTGTGGCCAGTACAAAGGCTTATACCAGC
CAGTTTGTATCCCTTGTGATGTTTGCCCTTATGATGTGTGATGATCGGATCTCCATGCAA
GAAAGACGCAAAGAGATCATGCTTGGATTGAAACGGCTGCCTGATTTGATTAAGGAAGTA
CTGAGCATGGATGACGAAATTCAGAAACTAGCAACAGAACTTTATCATCAGAAGTCAGTT
CTGATAATGGGACGAGGCTATCATTATGCTACTTGTCTTGAAGGGGCACTGAAAATCAAA
GAAATTACTTATATGCACTCTGAAGGCATCCTTGCTGGTGAATTGAAACATGGCCCTCTG
GCTTTGGTGGATAAATTGATGCCTGTGATCATGATCATCATGAGAGATCACACTTATGCC
AAGTGTCAGAATGCTCTTCAGCAAGTGGTTGCTCGGCAGGGGCGGCCTGTGGTAATTTGT
GATAAGGAGGATACTGAGACCATTAAGAACACAAAAAGAACGATCAAGGTGCCCCACTCA
GTGGACTGCTTGCAGGGCATTCTCAGCGTGATCCCTTTACAGTTGCTGGCTTTCCACCTT
GCTGTGCTGAGAGGCTATGATGTTGATTTCCCACGGAATCTTGCCAAATCTGTGACTGTA
GAGTGA

Protein Properties

Number of Residues

699

Molecular Weight

78805.81

Theoretical pI

7.107

Pfam Domain Function

GATase_2 (PF00310 )
SIS (PF01380 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1
MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGFDGGNDKDWEANACKIQLI
KKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIV
IHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQ
LEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSKFTRW
GSQGERGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVA
AVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRG
RVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELAS
DFLDRNTPVFRDDVCFFLSQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGV
HINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLS
MDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLAL
VDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVD
CLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE

External Links

GenBank ID Protein

205277386

UniProtKB/Swiss-Prot ID

Q06210

UniProtKB/Swiss-Prot Entry Name

GFPT1_HUMAN

PDB IDs

GenBank Gene ID

AC114772

GeneCard ID

GFPT1