Cannabis Compound Database: Showing Compound Card for L-Asparagine (CDB004813)

Jump To Section:

Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (11)transporters (2) Show 13 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:39:24 UTC

Updated at

2022-12-13 23:36:23 UTC

CannabisDB ID

CDB004813

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

L-Asparagine

Description

L-Asparagine, also known as Asn or aspartamic acid, belongs to the class of organic compounds known as asparagine and derivatives. Asparagine and derivatives are compounds containing asparagine or a derivative thereof resulting from reaction of asparagine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. L-Asparagine is a drug which is used for nutritional supplementation, also for treating dietary shortage or imbalance. L-Asparagine is a very strong basic compound (based on its pKa). L-Asparagine exists in all living species, ranging from bacteria to humans. Within humans, L-asparagine participates in a number of enzymatic reactions. In particular, L-asparagine and L-glutamic acid can be biosynthesized from L-aspartic acid and L-glutamine through the action of the enzyme asparagine synthetase [glutamine-hydrolyzing]. In addition, L-asparagine can be converted into L-aspartic acid through the action of the enzyme isoaspartyl peptidase/l-asparaginase. In humans, L-asparagine is involved in aspartate metabolism. L-Asparagine is an odorless tasting compound. Outside of the human body, L-Asparagine is found, on average, in the highest concentration within a few different foods, such as white lupines, wheats, and oats and in a lower concentration in sacred lotus, parsnips, and pineapples. L-Asparagine has also been detected, but not quantified in, several different foods, such as colorado pinyons, opium poppies, lentils, green beans, and watermelons. This could make L-asparagine a potential biomarker for the consumption of these foods. L-Asparagine is a potentially toxic compound. An optically active form of asparagine having L-configuration. L-Asparagine is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(2S)-2,4-Diamino-4-oxobutanoic acid	ChEBI
(2S)-2-Amino-3-carbamoylpropanoic acid	ChEBI
(S)-2-Amino-3-carbamoylpropanoic acid	ChEBI
(S)-Asparagine	ChEBI
2-Aminosuccinamic acid	ChEBI
alpha-Aminosuccinamic acid	ChEBI
Asn	ChEBI
ASPARAGINE	ChEBI
Aspartamic acid	ChEBI
L-2-Aminosuccinamic acid	ChEBI
L-Asparagin	ChEBI
L-Aspartic acid beta-amide	ChEBI
N	ChEBI
(2S)-2,4-Diamino-4-oxobutanoate	Generator
(2S)-2-Amino-3-carbamoylpropanoate	Generator
(S)-2-Amino-3-carbamoylpropanoate	Generator
2-Aminosuccinamate	Generator
a-Aminosuccinamate	Generator
a-Aminosuccinamic acid	Generator
alpha-Aminosuccinamate	Generator
Α-aminosuccinamate	Generator
Α-aminosuccinamic acid	Generator
Aspartamate	Generator
L-2-Aminosuccinamate	Generator
L-Aspartate b-amide	Generator
L-Aspartate beta-amide	Generator
L-Aspartate β-amide	Generator
L-Aspartic acid b-amide	Generator
L-Aspartic acid β-amide	Generator
(-)-Asparagine	HMDB
(S)-2,4-Diamino-4-oxobutanoate	HMDB
(S)-2,4-Diamino-4-oxobutanoic acid	HMDB
Agedoite	HMDB
alpha Amminosuccinamate	HMDB
alpha Amminosuccinamic acid	HMDB
Altheine	HMDB
Asparagine acid	HMDB
Asparamide	HMDB
Aspartic acid amide	HMDB
Aspartic acid b-amide	HMDB
Aspartic acid beta amide	HMDB
b2,4-(S)-Diamino-4-oxo-utanoate	HMDB
b2,4-(S)-Diamino-4-oxo-utanoic acid	HMDB
Crystal VI	HMDB
L-2,4-Diamino-4-oxobutanoate	HMDB
L-2,4-Diamino-4-oxobutanoic acid	HMDB
L-Aspartamine	HMDB
L-b-Asparagine	HMDB
L-beta-Asparagine	HMDB

Chemical Formula

C₄H₈N₂O₃

Average Molecular Weight

132.12

Monoisotopic Molecular Weight

132.0535

IUPAC Name

(2S)-2-amino-3-carbamoylpropanoic acid

Traditional Name

L-asparagine

CAS Registry Number

70-47-3

SMILES

N[C@@H](CC(N)=O)C(O)=O

InChI Identifier

InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1

InChI Key

DCXYFEDJOCDNAF-REOHCLBHSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as asparagine and derivatives. Asparagine and derivatives are compounds containing asparagine or a derivative thereof resulting from reaction of asparagine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Asparagine and derivatives

Alternative Parents

Substituents

Asparagine or derivatives
Alpha-amino acid
L-alpha-amino acid
Fatty amide
Fatty acyl
Fatty acid
Carboxamide group
Amino acid
Primary carboxylic acid amide
Carboxylic acid
Monocarboxylic acid or derivatives
Organic nitrogen compound
Primary amine
Organooxygen compound
Organonitrogen compound
Hydrocarbon derivative
Primary aliphatic amine
Organic oxide
Organopnictogen compound
Organic oxygen compound
Carbonyl group
Amine
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

aspartate family amino acid (CHEBI:17196 )
proteinogenic amino acid (CHEBI:17196 )
L-alpha-amino acid (CHEBI:17196 )
asparagine (CHEBI:17196 )
Common amino acids (C00152 )

Ontology

Leukemia

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Animal

Plant:

Biological location:

Tissue and substructures:

Organ and components:

Prostate

Biofluid and excreta:

Subcellular:

Cell and elements:

Extracellular

Role

Environmental role:

Environmental contaminant

Industrial application:

Food and nutrition:

Nutritional supplement

Pharmaceutical industry:

Pharmaceutical

Biological role:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	234 - 235 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	29.4 mg/mL	Not Available
logP	-3.82	CHMELIK,J ET AL. (1991)

Predicted Properties

Property	Value	Source
logP	-3.4	ALOGPS
logP	-4.3	ChemAxon
logS	0.1	ALOGPS
pKa (Strongest Acidic)	2	ChemAxon
pKa (Strongest Basic)	8.43	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	106.41 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	28.35 m³·mol⁻¹	ChemAxon
Polarizability	11.68 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	L-Asparagine, 3 TMS, GC-MS Spectrum	splash10-0159-0910000000-bedf57998656ab5ebc16	Spectrum
GC-MS	L-Asparagine, 3 TMS, GC-MS Spectrum	splash10-0159-0910000000-4979c4d028d2dc931263	Spectrum
GC-MS	L-Asparagine, non-derivatized, GC-MS Spectrum	splash10-0159-0910000000-b7ea3fef61f3940cbdda	Spectrum
GC-MS	L-Asparagine, 3 TMS, GC-MS Spectrum	splash10-00di-9710000000-6d0afcbcc003347e598e	Spectrum
GC-MS	L-Asparagine, 2 TMS, GC-MS Spectrum	splash10-0uxr-0910000000-2be567239bd3229b1ca1	Spectrum
GC-MS	L-Asparagine, non-derivatized, GC-MS Spectrum	splash10-02t9-0790000000-b8141f48cbebb90f683e	Spectrum
GC-MS	L-Asparagine, non-derivatized, GC-MS Spectrum	splash10-02t9-1790000000-1d12ed9b4fb2799da766	Spectrum
GC-MS	L-Asparagine, 4 TMS, GC-MS Spectrum	splash10-014u-0961000000-65a5c0999f17110c9939	Spectrum
GC-MS	L-Asparagine, 4 TMS, GC-MS Spectrum	splash10-00kr-0940000000-0e0e5c7bdbac5ea0e49e	Spectrum
GC-MS	L-Asparagine, 3 TMS, GC-MS Spectrum	splash10-00lr-1920000000-7864dbb1f685e64dd1cf	Spectrum
GC-MS	L-Asparagine, 4 TMS, GC-MS Spectrum	splash10-000i-1940000000-964ea25da2789805985a	Spectrum
GC-MS	L-Asparagine, non-derivatized, GC-MS Spectrum	splash10-00lr-0930000000-79a089d9875e092dd7f2	Spectrum
GC-MS	L-Asparagine, non-derivatized, GC-MS Spectrum	splash10-0159-0910000000-bedf57998656ab5ebc16	Spectrum
GC-MS	L-Asparagine, non-derivatized, GC-MS Spectrum	splash10-0159-0910000000-4979c4d028d2dc931263	Spectrum
GC-MS	L-Asparagine, non-derivatized, GC-MS Spectrum	splash10-0159-0910000000-b7ea3fef61f3940cbdda	Spectrum
GC-MS	L-Asparagine, non-derivatized, GC-MS Spectrum	splash10-00di-4931100000-17f149310ce3a0f748d1	Spectrum
GC-MS	L-Asparagine, non-derivatized, GC-MS Spectrum	splash10-00di-9710000000-6d0afcbcc003347e598e	Spectrum
GC-MS	L-Asparagine, non-derivatized, GC-MS Spectrum	splash10-0uxr-0910000000-2be567239bd3229b1ca1	Spectrum
GC-MS	L-Asparagine, non-derivatized, GC-MS Spectrum	splash10-02t9-0790000000-b8141f48cbebb90f683e	Spectrum
GC-MS	L-Asparagine, non-derivatized, GC-MS Spectrum	splash10-02t9-1790000000-1d12ed9b4fb2799da766	Spectrum
GC-MS	L-Asparagine, non-derivatized, GC-MS Spectrum	splash10-014u-0961000000-65a5c0999f17110c9939	Spectrum
GC-MS	L-Asparagine, non-derivatized, GC-MS Spectrum	splash10-00kr-0940000000-0e0e5c7bdbac5ea0e49e	Spectrum
GC-MS	L-Asparagine, non-derivatized, GC-MS Spectrum	splash10-00lr-1920000000-7864dbb1f685e64dd1cf	Spectrum
GC-MS	L-Asparagine, non-derivatized, GC-MS Spectrum	splash10-000i-1940000000-964ea25da2789805985a	Spectrum
Predicted GC-MS	L-Asparagine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-000f-9100000000-5881591331bd059b7e7d	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-0080-9400000000-e5c7e19f427eea6d71b0	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-00di-9000000000-afc1214100db1168b095	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-00dl-9000000000-57e977cd87e9a86d482b	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-6fb96f5aa291359dba29	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-9000000000-76f11e6fe5657c35d15f	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-9000000000-e944486273dbfde4cae4	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-27ad91a86be0c4d86c3c	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-b8b7a3431b66246ad613	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-9000000000-03fa294ec740e189dd99	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-9000000000-cee2081406fc25ab6169	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-cd79afa0c27f65e54adc	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-01q9-0943200000-5a24322ba0ce2f410155	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03di-0900000000-fc3086cc1bb0c06a4c11	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03di-3900000000-2d74d8232e7523f3b1c9	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0900000000-fa61c6fa9a87ce4905bb	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-01q9-0942200000-757da8b3406485c997b0	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-014i-9000000000-eac18512f2d22ab7a7ef	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03di-0900000000-8df6d5b6cf94bf081c89	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0900000000-18079004a95c252da208	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-001i-0900000000-e6b1f9b4982e6cdc863d	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-03di-5900000000-7b9c09b3b6de28972f97	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-00dl-9100000000-2ea95ead344d62e230a4	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-0006-9000000000-defacc365589bc4437d7	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-0006-9000000000-fd60db4d5e35794c45ae	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-001i-3900000000-fd0f1034b5c1e40435c0	2012-08-31	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Transcription/Translation	Not Available	Not Available
Aspartate Metabolism
Ammonia Recycling
Canavan Disease		Not Available
Hypoacetylaspartia		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Asparagine synthetase [glutamine-hydrolyzing]	ASNS	7q21.3	P08243	details
Asparagine--tRNA ligase, cytoplasmic	NARS	18q21.31	O43776	details
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	RPN1	3q21.3	P04843	details
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit	DDOST	1p36.1	P39656	details
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2	RPN2	20q12-q13.1	P04844	details
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A	STT3A	11q23.3	P46977	details
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1	DAD1	14q11.2	P61803	details
Isoaspartyl peptidase/L-asparaginase	ASRGL1	11q12.3	Q7L266	details
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B	STT3B	3p23	Q8TCJ2	details
60 kDa lysophospholipase	ASPG	14q32.33	Q86U10	details
Probable asparagine--tRNA ligase, mitochondrial	NARS2	11q14.1	Q96I59	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Neutral amino acid transporter B(0)	SLC1A5	19q13.3	Q15758	details
Sodium-coupled neutral amino acid transporter 3	SLC38A3	3p21.3	Q99624	details

Metal Bindings

Not Available

Receptors

Not Available

Transcriptional Factors

Not Available

Concentrations Data

Cannabis Cultivar	Status	Value	Reference	Details
Alien Dawg	Detected and Quantified	36.333 mg/g dry wt	David S. Wishart,...	details
Gabriola	Detected and Quantified	16.370 mg/g dry wt	David S. Wishart,...	details
Island Honey	Detected and Quantified	16.925 mg/g dry wt	David S. Wishart,...	details
Quadra	Detected and Quantified	13.542 mg/g dry wt	David S. Wishart,...	details
Sensi Star	Detected and Quantified	27.005 mg/g dry wt	David S. Wishart,...	details
Tangerine Dream	Detected and Quantified	13.159 mg/g dry wt	David S. Wishart,...	details

External Links

HMDB ID

HMDB0000168

DrugBank ID

DB00174

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

6267

PDB ID

Not Available

ChEBI ID

17196

References

General References

Not Available

Only showing the first 10 proteins. There are 13 proteins in total.

Show All

Enzymes

Enzyme Details

1. Asparagine synthetase [glutamine-hydrolyzing]

General function:: Involved in asparagine synthase (glutamine-hydrolyzing) activity
Specific function:: Not Available
Gene Name:: ASNS
Uniprot ID:: P08243
Molecular weight:: 62167.855

Enzyme Details

2. Asparagine--tRNA ligase, cytoplasmic

General function:: Involved in nucleotide binding
Specific function:: Not Available
Gene Name:: NARS
Uniprot ID:: O43776
Molecular weight:: 62942.425

Enzyme Details

3. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

General function:: Involved in dolichyl-diphosphooligosaccharide-protein glycotransferase activity
Specific function:: Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.
Gene Name:: RPN1
Uniprot ID:: P04843
Molecular weight:: 68568.81

Enzyme Details

4. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

General function:: Involved in dolichyl-diphosphooligosaccharide-protein glycotransferase activity
Specific function:: Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.
Gene Name:: DDOST
Uniprot ID:: P39656
Molecular weight:: 50701.205

Enzyme Details

5. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

General function:: Involved in dolichyl-diphosphooligosaccharide-protein glycotransferase activity
Specific function:: Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.
Gene Name:: RPN2
Uniprot ID:: P04844
Molecular weight:: 67722.73

Enzyme Details

6. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

General function:: Involved in oligosaccharyl transferase activity
Specific function:: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient cotranslational glycosylation and mediate glycosylation of sites that have been skipped by STT3A.
Gene Name:: STT3A
Uniprot ID:: P46977
Molecular weight:: 80528.83

Enzyme Details

7. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

General function:: Involved in dolichyl-diphosphooligosaccharide-protein g
Specific function:: Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis (By similarity).
Gene Name:: DAD1
Uniprot ID:: P61803
Molecular weight:: 12496.55

Enzyme Details

8. Isoaspartyl peptidase/L-asparaginase

General function:: Involved in hydrolase activity
Specific function:: Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.
Gene Name:: ASRGL1
Uniprot ID:: Q7L266
Molecular weight:: 32054.325

Enzyme Details

9. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

General function:: Involved in oligosaccharyl transferase activity
Specific function:: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient cotranslational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation.
Gene Name:: STT3B
Uniprot ID:: Q8TCJ2
Molecular weight:: 93673.495

Enzyme Details

10. 60 kDa lysophospholipase

General function:: Involved in asparaginase activity
Specific function:: Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities.
Gene Name:: ASPG
Uniprot ID:: Q86U10
Molecular weight:: 60882.4

Transporters

Enzyme Details

1. Neutral amino acid transporter B(0)

General function:: Involved in sodium:dicarboxylate symporter activity
Specific function:: Has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. Act as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses
Gene Name:: SLC1A5
Uniprot ID:: Q15758
Molecular weight:: 56597.6

Enzyme Details

2. Sodium-coupled neutral amino acid transporter 3

General function:: Amino acid transport and metabolism
Specific function:: Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission
Gene Name:: SLC38A3
Uniprot ID:: Q99624
Molecular weight:: 55772.4

Only showing the first 10 proteins. There are 13 proteins in total.

Show All

Showing Compound Card for L-Asparagine (CDB004813)

Structure for CDB004813 (L-Asparagine)

Enzymes

Transporters