Showing Protein Caspase-9 (CDBP05653)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP05653
Secondary Accession Numbers Not Available
Name Caspase-9
Description Not Available
Synonyms Not Available
Gene Name CASP9
Protein Type Enzyme
Biological Properties
General Function SH3 domain binding
Specific Function Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
GO Classification
Biological Process
response to estradiol stimulus
extrinsic apoptotic signaling pathway in absence of ligand
cellular response to dexamethasone stimulus
glial cell apoptotic process
intrinsic apoptotic signaling pathway in response to DNA damage
leukocyte apoptotic process
positive regulation of neuron apoptotic process
platelet formation
response to cobalt ion
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
positive regulation of apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of response to DNA damage stimulus
apoptotic process
response to ischemia
response to lipopolysaccharide
signal transduction in response to DNA damage
response to DNA damage stimulus
cellular response to UV
response to antibiotic
aging
kidney development
Cellular Component
cytosol
apoptosome
cytoplasm
protein-containing complex
mitochondrion
nucleus
Molecular Function
cysteine-type endopeptidase activity involved in apoptotic signaling pathway
protein kinase binding
peptidase activity
enzyme activator activity
SH3 domain binding
identical protein binding
cysteine-type endopeptidase activity
cysteine-type endopeptidase activity involved in apoptotic process
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 1
Locus 1p36.21
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 416
Molecular Weight 46280.325
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Caspase-9
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P55211
UniProtKB/Swiss-Prot Entry Name CASP9_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:1511
References
General References Not Available