| Identification |
|---|
| HMDB Protein ID
| CDBP05637 |
| Secondary Accession Numbers
| Not Available |
| Name
| Interleukin-13 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| IL13 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| interleukin-13 receptor binding |
| Specific Function
| Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity). |
| GO Classification
|
| Biological Process |
| microglial cell activation |
| positive regulation of gene expression |
| negative regulation of lung ciliated cell differentiation |
| positive regulation of B cell proliferation |
| negative regulation of NAD(P)H oxidase activity |
| positive regulation of smooth muscle cell proliferation |
| negative regulation of neuron death |
| negative regulation of transforming growth factor beta production |
| positive regulation of connective tissue growth factor production |
| negative regulation of inflammatory response |
| positive regulation of immunoglobulin production |
| response to lipopolysaccharide |
| positive regulation of lung goblet cell differentiation |
| inflammatory response |
| positive regulation of macrophage activation |
| response to ethanol |
| positive regulation of pancreatic stellate cell proliferation |
| positive regulation of tyrosine phosphorylation of STAT protein |
| response to nicotine |
| positive regulation of release of sequestered calcium ion into cytosol |
| macrophage activation |
| positive regulation of mast cell degranulation |
| negative regulation of complement-dependent cytotoxicity |
| immune response |
| negative regulation of endothelial cell apoptotic process |
| cytokine-mediated signaling pathway |
| positive regulation of cold-induced thermogenesis |
| regulation of proton transport |
| positive regulation of interleukin-10 secretion |
| cellular response to mechanical stimulus |
| Cellular Component |
| cytoplasm |
| extracellular region |
| extracellular space |
| external side of plasma membrane |
| cell |
| Molecular Function |
| cytokine activity |
| interleukin-13 receptor binding |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| 5q31.1 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 146 |
| Molecular Weight
| 15815.585 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Interleukin-13
MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAP
LCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRD
TKIEVAQFVKDLLLHLKKLFREGRFN
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P35225 |
| UniProtKB/Swiss-Prot Entry Name
| IL13_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:5973 |
| References |
|---|
| General References
| Not Available |