| Identification |
|---|
| HMDB Protein ID
| CDBP05627 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein ERGIC-53 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| LMAN1 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| unfolded protein binding |
| Specific Function
| Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. |
| GO Classification
|
| Biological Process |
| protein transport |
| protein folding |
| ER to Golgi vesicle-mediated transport |
| protein N-linked glycosylation via asparagine |
| blood coagulation |
| COPII vesicle coating |
| endoplasmic reticulum organization |
| Golgi organization |
| negative regulation of protein targeting to mitochondrion |
| positive regulation of organelle organization |
| Cellular Component |
| collagen-containing extracellular matrix |
| COPII-coated ER to Golgi transport vesicle |
| endoplasmic reticulum-Golgi intermediate compartment membrane |
| ER to Golgi transport vesicle membrane |
| host cell perinuclear region of cytoplasm |
| sarcomere |
| endoplasmic reticulum membrane |
| cytosol |
| extracellular vesicular exosome |
| endoplasmic reticulum-Golgi intermediate compartment |
| membrane |
| integral to membrane |
| Golgi membrane |
| Molecular Function |
| unfolded protein binding |
| metal ion binding |
| mannose binding |
|
| Cellular Location
|
- Golgi apparatus membrane
- Endoplasmic reticulum membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| 18q21.32 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 510 |
| Molecular Weight
| 57548.665 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protein ERGIC-53
MAGSRQRGLRARVRPLFCALLLSLGRFVRGDGVGGDPAVALPHRRFEYKYSFKGPHLVQS
DGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGA
DGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQN
DGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPA
QGHFGISAATGGLADDHDVLSFLTFQLTEPGKEPPTPDKEISEKEKEKYQEEFEHFQQEL
DKKKEEFQKGHPDLQGQPAEEIFESVGDRELRQVFEGQNRIHLEIKQLNRQLDMILDEQR
RYVSSLTEEISKRGAGMPGQHGQITQQELDTVVKTQHEILRQVNEMKNSMSETVRLVSGM
QHPGSAGGVYETTQHFIDIKEHLHIVKRDIDNLVQRNMPSNEKPKCPELPPFPSCLSTVH
FIIFVVVQTVLFIGYIMYRSQQEAAAKKFF
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P49257 |
| UniProtKB/Swiss-Prot Entry Name
| LMAN1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:6631 |
| References |
|---|
| General References
| Not Available |