| Identification |
|---|
| HMDB Protein ID
| CDBP05617 |
| Secondary Accession Numbers
| Not Available |
| Name
| ER degradation-enhancing alpha-mannosidase-like protein 2 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| EDEM2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| mannosyl-oligosaccharide 1,2-alpha-mannosidase activity |
| Specific Function
| Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15537790, PubMed:25092655). May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity). |
| GO Classification
|
| Biological Process |
| trimming of terminal mannose on C branch |
| ubiquitin-dependent glycoprotein ERAD pathway |
| trimming of first mannose on A branch |
| trimming of second mannose on A branch |
| trimming of terminal mannose on B branch |
| response to unfolded protein |
| mannose trimming involved in glycoprotein ERAD pathway |
| positive regulation of retrograde protein transport, ER to cytosol |
| Cellular Component |
| endoplasmic reticulum |
| endoplasmic reticulum lumen |
| endoplasmic reticulum quality control compartment |
| membrane |
| Molecular Function |
| mannosyl-oligosaccharide 1,2-alpha-mannosidase activity |
| calcium ion binding |
|
| Cellular Location
|
- Endoplasmic reticulum lumen
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 20 |
| Locus
| 20q11.22 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 541 |
| Molecular Weight
| 64752.365 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>ER degradation-enhancing alpha-mannosidase-like protein 2
MPFRLLIPLGLLCALLPQHHGAPGPDGSAPDPAHYRERVKAMFYHAYDSYLENAFPFDEL
RPLTCDGHDTWGSFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNI
RVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLH
GVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHID
VLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWV
QMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYT
VEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHK
LDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAHPI
DPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENH
DQARERKPAKQKVPLLSCPSQPFTSKLALLGQVFLDSS
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9BV94 |
| UniProtKB/Swiss-Prot Entry Name
| EDEM2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:15877 |
| References |
|---|
| General References
| Not Available |