Showing Protein Ubiquitin-associated and SH3 domain-containing protein B (CDBP05547)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP05547
Secondary Accession Numbers Not Available
Name Ubiquitin-associated and SH3 domain-containing protein B
Description Not Available
Synonyms
  1. Cbl-interacting protein p70
  2. Suppressor of T-cell receptor signaling 1
  3. T-cell ubiquitin ligand 2
  4. Tyrosine-protein phosphatase STS1/TULA2
  5. STS-1
  6. TULA-2
Gene Name UBASH3B
Protein Type Enzyme
Biological Properties
General Function Not Available
Specific Function Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
GO Classification
Biological Process
peptidyl-tyrosine dephosphorylation
Cellular Component
cytoplasm
nucleus
Molecular Function
protein tyrosine phosphatase activity
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 11
Locus 11q24.1
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 72695.32
Theoretical pI 6.927
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>gi|24497612|ref|NP_116262.2| ubiquitin-associated and SH3 domain-containing protein B [Homo sapiens]
MAQYGHPSPLGMAAREELYSKVTPRRNRQQRPGTIKHGSALDVLLSMGFPRARAQKALAS
TGGRSVQAAC
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q8TF42
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:29884
References
General References Not Available