Showing Protein Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA (CDBP05381)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 compounds
Identification
HMDB Protein ID CDBP05381
Secondary Accession Numbers Not Available
Name Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
Description Not Available
Synonyms
  1. 60S ribosomal protein L27a histidine hydroxylase
  2. Histone lysine demethylase MINA
  3. MYC-induced nuclear antigen
  4. Mineral dust-induced gene protein
  5. Nucleolar protein 52
  6. Ribosomal oxygenase MINA
  7. ROX
Gene Name MINA
Protein Type Enzyme
Biological Properties
General Function Not Available
Specific Function Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
GO Classification
Biological Process
ribosome biogenesis
Cellular Component
cytoplasm
nucleolus
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 3
Locus 3q11.2
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 52799.83
Theoretical pI 6.695
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>gi|110227619|ref|NP_001035998.1| bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA isoform a [Homo sapiens]
MPKKAKPTGSGKEEGPAPCKQMKLEAAGGPSALNFDSPSSLFESLISPIKTETFFKEFWE
QKPLLIQRDD
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q8IUF8
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:19441
References
General References Not Available