| Identification |
|---|
| HMDB Protein ID
| CDBP05368 |
| Secondary Accession Numbers
| Not Available |
| Name
| DNA replication licensing factor MCM2 |
| Description
| Not Available |
| Synonyms
|
- Minichromosome maintenance protein 2 homolog
- Nuclear protein BM28
|
| Gene Name
| MCM2 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.
|
| GO Classification
|
| Biological Process |
| G1/S transition of mitotic cell cycle |
| cell cycle checkpoint |
| DNA strand elongation involved in DNA replication |
| DNA replication initiation |
| M/G1 transition of mitotic cell cycle |
| DNA unwinding involved in replication |
| nucleosome assembly |
| S phase of mitotic cell cycle |
| Cellular Component |
| nucleoplasm |
| chromatin |
| MCM complex |
| nuclear origin of replication recognition complex |
| Molecular Function |
| metal ion binding |
| ATP binding |
| DNA replication origin binding |
| DNA binding |
| helicase activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | DNA replication | Not Available |  | | Cell cycle | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3q21 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 101895.155 |
| Theoretical pI
| 5.513 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>gi|33356547|ref|NP_004517.2| DNA replication licensing factor MCM2 [Homo sapiens]
MAESSESFTMASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTE
GPLEEEEDGE
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P49736 |
| UniProtKB/Swiss-Prot Entry Name
| Not Available |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:6944 |
| References |
|---|
| General References
| Not Available |