Showing Protein CTD small phosphatase-like protein (CDBP05203)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP05203
Secondary Accession Numbers Not Available
Name CTD small phosphatase-like protein
Description Not Available
Synonyms
  1. CTDSP-like
  2. Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3
  3. NIF-like protein
  4. Nuclear LIM interactor-interacting factor 1
  5. Protein YA22
  6. RBSP3
  7. Small C-terminal domain phosphatase 3
  8. NLI-interacting factor 1
  9. hYA22
  10. SCP3
  11. Small CTD phosphatase 3
Gene Name CTDSPL
Protein Type Enzyme
Biological Properties
General Function Not Available
Specific Function Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
GO Classification
Biological Process
dephosphorylation
Cellular Component
nucleus
Molecular Function
phosphoprotein phosphatase activity
metal ion binding
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 3
Locus 3p21.3
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 31128.305
Theoretical pI 5.535
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>gi|56549683|ref|NP_001008393.1| CTD small phosphatase-like protein isoform 1 [Homo sapiens]
MDGPAIITQVTNPKEDEGRLPGAGEKASQCNVSLKKQRSRSILSSFFCCFRDYNVEAPPP
SSPSVLPPLV
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O15194
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:16890
References
General References Not Available