| Identification |
|---|
| HMDB Protein ID
| CDBP05178 |
| Secondary Accession Numbers
| Not Available |
| Name
| ATPase family AAA domain-containing protein 2 |
| Description
| Not Available |
| Synonyms
|
- AAA nuclear coregulator cancer-associated protein
- ANCCA
|
| Gene Name
| ATAD2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.
|
| GO Classification
|
| Biological Process |
| ATP catabolic process |
| regulation of transcription, DNA-dependent |
| transcription, DNA-dependent |
| Cellular Component |
| nucleus |
| Molecular Function |
| ATP binding |
| ATPase activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| 8q24.13 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 158552.525 |
| Theoretical pI
| 6.32 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>gi|24497618|ref|NP_054828.2| ATPase family AAA domain-containing protein 2 [Homo sapiens]
MVVLRSSLELHNHSAASATGSLDLSSDFLSLEHIGRRRLRSAGAAQKKPAATTAKAGDGS
SVKEVETYHR
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q6PL18 |
| UniProtKB/Swiss-Prot Entry Name
| Not Available |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:30123 |
| References |
|---|
| General References
| Not Available |