Cannabis Compound Database: Showing Protein S-acyl fatty acid synthase thioesterase, medium chain (CDBP05140)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 compounds

Identification

HMDB Protein ID

CDBP05140

Secondary Accession Numbers

Not Available

Name

S-acyl fatty acid synthase thioesterase, medium chain

Description

Not Available

Synonyms

Oleoyl-ACP hydrolase
Thioesterase II
Thioesterase domain-containing protein 1
Augmented in rheumatoid arthritis 1
AURA1

Gene Name

OLAH

Protein Type

Enzyme

Biological Properties

General Function

Involved in biosynthetic process

Specific Function

In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids (C8 to C2) (By similarity).

GO Classification

Biological Process
fatty acid biosynthetic process
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
Molecular Function
myristoyl-[acyl-carrier-protein] hydrolase activity
oleoyl-[acyl-carrier-protein] hydrolase activity
palmitoyl-[acyl-carrier-protein] hydrolase activity
Process
metabolic process
biosynthetic process

Cellular Location

Cytoplasmic

Pathways

Not Available

Gene Properties

Chromosome Location

Locus

10p13

SNPs

OLAH

Gene Sequence

>798 bp
ATGGAGAGAGGAGACCAACCTAAGAGAACCAGGAATGAAAACATTTTCAACTGCTTATAC
AAAAACCCTGAGGCAACTTTTAAGCTGATTTGCTTTCCCTGGATGGGAGGTGGCTCCACT
CATTTTGCCAAATGGGGCCAAGATACTCATGATTTGCTGGAAGTGCACTCCTTAAGGCTT
CCTGGAAGAGAAAGCAGAGTTGAAGAACCTCTTGAAAATGACATCTCCCAGTTAGTTGAT
GAAGTTGTTTGTGCTCTGCAGCCAGTCATCCAGGATAAACCATTTGCATTTTTTGGCCAC
AGTATGGGATCCTACATTGCTTTTAGGACTGCACTAGGTCTAAAAGAAAACAATCAACCA
GAACCATTGCATTTATTTTTGTCAAGTGCAACTCCTGTACATTCAAAGGCCTGGCATCGC
ATTCCCAAAGATGATGAATTGTCAGAAGAACAAATAAGTCATTACCTTATGGAATTTGGA
GGCACCCCCAAGCATTTTGCTGAAGCCAAGGAATTTGTGAAACAATGTAGTCCCATCATA
AGGGCAGATCTGAACATTGTTAGAAGTTGCACCTCTAACGTACCATCTAAGGCTGTTCTT
TCCTGTGACTTGACATGTTTTGTTGGATCTGAAGACATAGCAAAGGACATGGAAGCCTGG
AAAGATGTAACCAGTGGAAATGCTAAAATTTACCAGCTTCCAGGGGGTCACTTTTATCTT
CTGGATCCTGCGAACGAGAAATTAATCAAGAACTACATAATCAAGTGTCTAGAAGTATCA
TCGATATCCAATTTTTAG

Protein Properties

Number of Residues

265

Molecular Weight

29930.82

Theoretical pI

6.223

Pfam Domain Function

Thioesterase (PF00975 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>S-acyl fatty acid synthase thioesterase, medium chain
MERGDQPKRTRNENIFNCLYKNPEATFKLICFPWMGGGSTHFAKWGQDTHDLLEVHSLRL
PGRESRVEEPLENDISQLVDEVVCALQPVIQDKPFAFFGHSMGSYIAFRTALGLKENNQP
EPLHLFLSSATPVHSKAWHRIPKDDELSEEQISHYLMEFGGTPKHFAEAKEFVKQCSPII
RADLNIVRSCTSNVPSKAVLSCDLTCFVGSEDIAKDMEAWKDVTSGNAKIYQLPGGHFYL
LDPANEKLIKNYIIKCLEVSSISNF

External Links

GenBank ID Protein

7023364

UniProtKB/Swiss-Prot ID

Q9NV23

UniProtKB/Swiss-Prot Entry Name

SAST_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AK001844

GeneCard ID