Showing Protein Serine/threonine-protein kinase LMTK2 (CDBP05126)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP05126
Secondary Accession Numbers Not Available
Name Serine/threonine-protein kinase LMTK2
Description Not Available
Synonyms
  1. Apoptosis-associated tyrosine kinase 2
  2. Brain-enriched kinase
  3. CDK5/p35-regulated kinase
  4. CPRK
  5. Kinase/phosphatase/inhibitor 2
  6. Lemur tyrosine kinase 2
  7. Serine/threonine-protein kinase KPI-2
  8. hBREK
Gene Name LMTK2
Protein Type Enzyme
Biological Properties
General Function Involved in protein kinase activity
Specific Function Phosphorylates PPP1C, phosphorylase b and CFTR
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
adenyl ribonucleotide binding
atp binding
protein binding
protein kinase activity
protein serine/threonine kinase activity
protein tyrosine kinase activity
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
protein amino acid autophosphorylation
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Membrane
  2. Single-pass membrane protein (Potential)
Pathways
Gene Properties
Chromosome Location Chromosome:7
Locus 7q21.3
SNPs LMTK2
Gene Sequence 
>4512 bp
ATGCCGGGGCCGCCGGCGTTGCGGCGGAGGCTGCTGCTGCTGCTGCTGGTCCTCCTGATC
GCCGGCAGTGCTGGGGCCGCGCCACTTCCGCAAACAGGTGCAGGGGAGGCGCCACCTGCT
GCAGAAGTTTCCTCATCTTTTGTGATCCTGTGTGTGTGCAGTTTAATAATATTAATAGTG
TTAATTGCAAACTGTGTATCCTGCTGTAAGGACCCAGAAATAGACTTTAAGGAATTTGAA
GATAATTTTGATGATGAGATAGATTTCACACCACCAGCAGAAGACACTCCCTCTGTTCAG
TCCCCAGCAGAGGTCTTCACACTTTCAGTACCAAATATTTCACTCCCAGCTCCCTCGCAA
TTCCAGCCTTCTGTAGAGGGATTGAAGTCTCAAGTTGCCCGCCACAGTCTAAACTACATA
CAGGAAATTGGAAATGGCTGGTTTGGAAAGGTTCTCTTGGGAGAGATTTACACGGGCACT
AGCGTAGCAAGAGTCATCGTGAAGGAGTTAAAAGCAAGTGCCAACCCAAAGGAACAAGAT
ACTTTTTTGAAAAATGGAGAACCTTACTACATTCTTCAGCATCCAAATATTCTTCAGTGT
GTTGGACAGTGCGTAGAAGCGATTCCCTACCTCCTGGTGTTTGAGTTCTGTGACTTGGGT
GACCTGAAGGCGTATCTGCGCAGCGAGCAGGAGCACATGCGGGGGGACTCACAGACCATG
CTGCTGCAGAGGATGGCGTGCGAGGTCGCCGCGGGGCTGGCCGCCATGCACAAGCTGCAC
TTCCTGCACAGTGATTTAGCCCTGCGGAATTGTTTTCTCACCTCCGACTTAAATGTGAAA
GTGGGAGATTACGGAATAGGATTCAGCAGGTACAAGGAGGATTATATTGAAACAGATGAT
AAAAAAGTTTTCCCTCTGCGATGGACTGCTCCAGAATTAGTAACCAGCTTTCAAGACAGA
CTGCTAACTGCAGATCAGACTAAGTATAGTAATATCTGGTCTCTGGGTGTGACACTTTGG
GAGCTTTTTGACAATGCCGCACAGCCGTATTCAAACCTTTCCAACTTAGATGTCCTCAAC
CAAGTCATTAGAGAGAGAGACACAAAACTCCCGAAGCCCCAGCTGGAGCAGCCCTACTCT
GATAGATGGTATGAAGTCTTACAGTTCTGTTGGCTGTCACCAGAAAAGAGACCCGCGGCT
GAAGATGTGCACAGGCTGCTGACTTACCTGCGGCTGCAGAGCCAGCGGGACTCAGAGGTC
GACTTTGAACAGCAGTGGAACGCTCTGAAGCCGAACACAAACAGCAGAGACTCCTCCAAC
AATGCTGCATTCCCAATTCTCGACCACTTTGCCAGGGACCGGCTGGGTCGTGAAATGGAG
GAAGTCCTCACCGTGACCGAAACCAGCCAGGGCCTGAGCTTCGAGTATGTCTGGGAGGCC
GCTAAGCACGACCACTTTGACGAGCGCAGCCGGGGCCACCTGGACGAAGGCTTGTCCTAC
ACGAGCATCTTCTATCCGGTTGAAGTTTTTGAGAGTTCGCTTTCAGATCCTGGGCCCGGA
AAGCAAGATGACAGCGGCCAGGATGTCCCCCTGAGGGTCCCTGGAGTGGTTCCTGTTTTT
GATGCCCACAACCTTTCTGTTGGAAGCGACTATTATATCCAGTTAGAAGAAAAAAGTGGT
AGTAACTTGGAGCTTGATTACCCACCAGCGCTGCTCACAACCGACATGGATAATCCAGAA
AGGACTGGCCCTGAACTGTCCCAGCTCACGGCGCTCAGGAGCGTTGAACTTGAGGAGTCC
AGTACAGATGAGGACTTCTTCCAAAGCAGTACAGACCCCAAAGACTCTAGCTTACCAGGG
GACTTACACGTGACCAGTGGCCCCGAGAGCCCTTTCAACAATATATTTAATGATGTGGAC
AAATCGGAAGATTTGCCCAGTCACCAAAAAATATTCGACTTAATGGAATTAAACGGAGTT
CAAGCCGACTTTAAACCTGCCACTTTAAGTTCCAGTTTGGATAACCCCAAAGAGTCAGTC
ATAACAGGCCACTTTGAGAAAGAAAAGCCCCGTAAGATTTTTGACAGTGAGCCTCTCTGC
CTATCAGATAATCTTATGCACCAAGATAATTTTGATCCATTGAATGTTCAAGAATTGTCA
GAAAACTTTTTATTTCTTCAAGAGAAAAACTTACTAAAAGGCTCATTGTCCAGCAAAGAA
CACATAAATGATCTTCAGACAGAACTTAAGAATGCTGGTTTTACTGAAGCTATGTTAGAA
ACGTCATGTAGAAACTCTTTAGATACTGAGCTTCAGTTTGCTGAAAATAAGCCAGGCTTG
TCTTTGTTGCAGGAAAACGTAAGCACAAAGGGTGACGATACAGATGTCATGCTCACAGGT
GACACTTTGAGCACCTCATTGCAGTCTTCCCCGGAAGTGCAGGTACCTCCTACCTCCTTC
GAAACAGAAGAAACGCCCCGTCGGGTACCCCCAGACTCACTCCCAACACAGGGAGAAACC
CAGCCCACGTGTTTAGATGTTATTGTCCCGGAGGACTGTCTCCACCAGGACATCAGTCCA
GACGCTGTGACTGTCCCGGTTGAAATTCTCTCAACTGATGCCAGAACCCACAGCCTGGAT
AACAGGTCCCAGGACTCTCCTGGCGAGAGTGAGGAGACCCTGCGACTCACCGAAAGTGAC
TCTGTTCTTGCTGATGACATCCTTGCCAGCAGGGTGAGTGTAGGGAGTAGTCTCCCGGAA
CTGGGACAGGAATTGCACAATAAACCATTTTCGGAAGACCATCACAGTCATCGCCGGCTA
GAGAAAAACTTAGAGGCTGTGGAGACTTTAAATCAGCTCAATTCTAAAGACGCAGCAAAA
GAAGCAGGCTTGGTGTCTGCCCTCTCCTCGGACTCAACCAGTCAGGACAGCCTCCTGGAG
GACAGCTTGTCAGCACCCTTCCCAGCCTCTGAGCCGTCCCTGGAAACCCCGGACTCTCTG
GAGTCAGTGGATGTCCACGAAGCGCTACTGGACTCTTTAGGATCTCACACTCCCCAGAAA
CTAGTGCCCCCCGATAAGCCGGCAGACAGTGGCTACGAAACAGAGAACTTGGAGTCTCCC
GAGTGGACCTTGCATCCCGCTCCCGAGGGCACCGCAGACTCAGAACCAGCCACCACGGGC
GATGGCGGCCACAGCGGTCTGCCTCCCAACCCGGTCATTGTCATCTCAGATGCCGGCGAT
GGTCACAGAGGCACAGAAGTGACCCCTGAGACGTTCACAGCTGGCTCCCAGGGTTCATAC
CGAGACTCTGCGTACTTCTCAGACAATGACTCTGAGCCCGAGAAAAGGTCTGAGGAGGTC
CCGGGAACCTCCCCATCCGCCTTGGTGTTGGTACAGGAGCAGCCCCTACCCGAGCCAGTC
CTCCCCGAGCAAAGTCCTGCTGCCCAGGATAGCTGCCTGGAAGCCAGAAAGAGCCAGCCA
GATGAAAGTTGTCTGTCTGCTTTGCACAACTCCAGTGACCTGGAATTAAGAGCCACGCCG
GAGCCAGCACAGACTGGTGTTCCCCAGCAGGTGCATCCCACGGAAGACGAGGCCAGCAGT
CCCTGGAGTGTGCTGAATGCAGAACTTAGCAGCGGCGATGACTTCGAGACACAGGACGAT
CGCCCCTGCACCCTCGCTTCCACGGGGACCAACACGAACGAACTCCTTGCCTACACCAAT
TCTGCGCTGGACAAGTCCCTGTCCAGCCACTCCGAGGGCCCGAAGTTGAAGGAGCCGGAC
ATCGAAGGGAAGTACCTGGGGAAACTCGGGGTGTCAGGGATGCTCGACCTCTCAGAGGAC
GGGATGGATGCAGACGAGGAGGACGAAAACAGCGACGACTCGGACGAGGACCTGCGGGCC
TTCAACCTGCATAGCCTCAGCTCCGAGTCGGAGGACGAGACCGAGCACCCCGTGCCCATC
ATCCTCAGCAACGAGGACGGAAGGCACCTGCGGAGTCTGTTGAAGCCCACAGCGGCCAAT
GCCCCCGACCCACTGCCCGAGGACTGGAAGAAGGAAAAGAAGGCAGTCACGTTTTTCGAT
GATGTCACAGTCTACCTGTTTGACCAGGAGACCCCAACCAAAGAGCTGGGGCCCTGTGGA
GGAGAGGCGTGCGGCCCGGACCTGAGCGGCCCAGCCCCAGCCTCAGGCTCTCCCTACCTG
AGCAGGTGCATCAACTCCGAAAGCTCCACCGACGAAGAAGGTGGTGGCTTTGAGTGGGAT
GATGACTTCTCCCCAGATCCTTTTATGTCAAAGACAACAAGTAACCTGCTCAGCTCCAAG
CCTTCTCTCCAAACATCCAAGTACTTTTCTCCGCCGCCACCGGCCCGGAGCACGGAGCAG
AGCTGGCCGCACTCGGCGCCTTACTCCCGGTTCTCCATCTCTCCCGCCAACATTGCCAGC
TTTTCCCTCACACACCTGACCGACTCGGACATCGAGCAGGGCGGAAGCAGCGAAGACGGA
GAAAAGGACTAG
Protein Properties
Number of Residues 1503
Molecular Weight 164898.6
Theoretical pI 4.09
Pfam Domain Function
Signals
  • ["1-26"]
Transmembrane Regions
  • ["43-63"]
Protein Sequence 
>Serine/threonine-protein kinase LMTK2
MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTGAGEAPPAAEVSSSFVILCVCSLIILIV
LIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPSQ
FQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQD
TFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTM
LLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDD
KKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLN
QVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLSPEKRPAAEDVHRLLTYLRLQSQRDSEV
DFEQQWNALKPNTNSRDSSNNAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEA
AKHDHFDERSRGHLDEGLSYTSIFYPVEVFESSLSDPGPGKQDDSGQDVPLRVPGVVPVF
DAHNLSVGSDYYIQLEEKSGSNLELDYPPALLTTDMDNPERTGPELSQLTALRSVELEES
STDEDFFQSSTDPKDSSLPGDLHVTSGPESPFNNIFNDVDKSEDLPSHQKIFDLMELNGV
QADFKPATLSSSLDNPKESVITGHFEKEKPRKIFDSEPLCLSDNLMHQDNFDPLNVQELS
ENFLFLQEKNLLKGSLSSKEHINDLQTELKNAGFTEAMLETSCRNSLDTELQFAENKPGL
SLLQENVSTKGDDTDVMLTGDTLSTSLQSSPEVQVPPTSFETEETPRRVPPDSLPTQGET
QPTCLDVIVPEDCLHQDISPDAVTVPVEILSTDARTHSLDNRSQDSPGESEETLRLTESD
SVLADDILASRVSVGSSLPELGQELHNKPFSEDHHSHRRLEKNLEAVETLNQLNSKDAAK
EAGLVSALSSDSTSQDSLLEDSLSAPFPASEPSLETPDSLESVDVHEALLDSLGSHTPQK
LVPPDKPADSGYETENLESPEWTLHPAPEGTADSEPATTGDGGHSGLPPNPVIVISDAGD
GHRGTEVTPETFTAGSQGSYRDSAYFSDNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPV
LPEQSPAAQDSCLEARKSQPDESCLSALHNSSDLELRATPEPAQTGVPQQVHPTEDEASS
PWSVLNAELSSGDDFETQDDRPCTLASTGTNTNELLAYTNSALDKSLSSHSEGPKLKEPD
IEGKYLGKLGVSGMLDLSEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDETEHPVPI
ILSNEDGRHLRSLLKPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGPCG
GEACGPDLSGPAPASGSPYLSRCINSESSTDEEGGGFEWDDDFSPDPFMSKTTSNLLSSK
PSLQTSKYFSPPPPARSTEQSWPHSAPYSRFSISPANIASFSLTHLTDSDIEQGGSSEDG
EKD
GenBank ID Protein 38016937
UniProtKB/Swiss-Prot ID Q8IWU2
UniProtKB/Swiss-Prot Entry Name LMTK2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_014916.3
GeneCard ID LMTK2
GenAtlas ID LMTK2
HGNC ID HGNC:17880
References
General References Not Available