Cannabis Compound Database: Showing Protein Ubiquitin carboxyl-terminal hydrolase 37 (CDBP05124)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP05124

Secondary Accession Numbers

Not Available

Name

Ubiquitin carboxyl-terminal hydrolase 37

Description

Not Available

Synonyms

Deubiquitinating enzyme 37
Ubiquitin thiolesterase 37
Ubiquitin-specific-processing protease 37

Gene Name

USP37

Protein Type

Enzyme

Biological Properties

General Function

Involved in ubiquitin thiolesterase activity

Specific Function

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

GO Classification

Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
ubiquitin thiolesterase activity
thiolester hydrolase activity
Process
metabolic process
catabolic process
macromolecule catabolic process
cellular macromolecule catabolic process
modification-dependent macromolecule catabolic process
modification-dependent protein catabolic process
ubiquitin-dependent protein catabolic process

Cellular Location

Cytoplasmic

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:2

Locus

2q35

SNPs

USP37

Gene Sequence

>2940 bp
ATGTCTCCTCTGAAGATACATGGTCCTATCAGAATTCGAAGTATGCAGACTGGGATTACA
AAGTGGAAAGAAGGATCCTTTGAAATTGTAGAAAAAGAGAATAAAGTCAGCCTAGTAGTT
CACTACAATACTGGAGGAATTCCAAGGATATTTCAGCTAAGTCATAACATTAAAAATGTG
GTGCTTCGACCCAGTGGAGCGAAACAAAGCCGCCTAATGTTAACTCTGCAAGATAACAGC
TTCTTGTCTATTGACAAAGTACCAAGTAAGGATGCAGAGGAAATGAGGTTGTTTCTAGAT
GCAGTCCATCAAAACAGACTTCCTGCAGCCATGAAACCGTCTCAGGGGTCTGGTAGTTTT
GGAGCCATTCTGGGCAGCAGGACCTCACAGAAGGAAACCAGCAGGCAGCTTTCTTACTCA
GACAATCAGGCTTCTGCAAAAAGAGGAAGTTTGGAAACTAAAGATGATATTCCATTTCGA
AAAGTTCTTGGTAATCCGGGTAGAGGATCGATTAAGACTGTAGCAGGAAGTGGAATAGCT
CGGACGATTCCTTCTTTGACATCTACTTCAACACCTCTTAGATCAGGGTTGCTAGAAAAT
CGTACTGAAAAGAGGAAAAGAATGATATCAACTGGCTCAGAATTGAATGAAGATTACCCT
AAGGAAAATGATTCATCATCGAACAACAAGGCCATGACAGATCCCTCCAGAAAGTATTTA
ACCAGCAGTAGAGAAAAGCAGCTGAGTTTGAAACAGTCAGAAGAGAATAGGACATCAGGG
CTTTTACCTTTACAGTCATCATCCTTTTATGGTAGCAGAGCTGGATCCAAGGAACACTCT
TCTGGTGGCACTAACTTAGACAGGACTAATGTTTCAAGCCAGACTCCCTCTGCCAAAAGA
AGTTTGGGATTTCTTCCTCAGCCAGTTCCTCTTTCTGTTAAAAAACTGAGGTGTAACCAG
GATTACACTGGCTGGAATAAACCAAGAGTGCCCCTTTCCTCTCACCAACAGCAGCAACTG
CAGGGCTTCTCCAATTTGGGAAATACCTGCTATATGAATGCTATTCTACAATCTCTATTT
TCACTCCAGTCATTTGCAAATGACTTGCTTAAACAAGGTATCCCATGGAAGAAAATTCCA
CTCAATGCACTTATCAGACGCTTTGCACACTTGCTTGTTAAAAAAGATATCTGTAATTCA
GAGACCAAAAAGGATTTACTCAAGAAGGTTAAAAATGCCATTTCAGCTACAGCAGAGAGA
TTCTCTGGTTATATGCAGAATGATGCTCATGAATTTTTAAGTCAGTGTTTGGACCAGCTG
AAAGAAGATATGGAAAAATTAAATAAAACTTGGAAGACTGAACCTGTTTCTGGAGAAGAA
AATTCACCAGATATTTCAGCTACCAGAGCATACACTTGCCCTGTTATTACTAATTTGGAG
TTTGAGGTTCAGCACTCCATCATTTGTAAAGCATGTGGAGAGATTATCCCCAAAAGAGAA
CAGTTTAATGACCTCTCTATTGACCTTCCTCGTAGGAAAAAACCACTCCCTCCTCGTTCA
ATTCAAGATTCTCTTGATCTTTTCTTTAGGGCCGAAGAACTGGAGTATTCTTGTGAGAAG
TGTGGTGGGAAGTGTGCTCTTGTCAGGCACAAATTTAACAGGCTTCCTAGGGTCCTCATT
CTCCATTTGAAACGATATAGCTTCAATGTGGCTCTCTCGCTTAACAATAAGATTGGGCAG
CAAGTCATCATTCCAAGATACCTGACCCTGTCATCTCATTGCACTGAAAATACAAAACCA
CCTTTTACCCTTGGTTGGAGTGCACATATGGCAATTTCTAGACCATTGAAAGCCTCTCAA
ATGGTGAATTCCTGCATCACCAGCCCTTCTACACCTTCAAAGAAATTCACCTTCAAATCC
AAGAGCTCCTTGGCTTTATGCCTTGATTCAGACAGTGAGGATGAGCTAAAACGTTCTGTG
GCCCTCAGCCAGAGACTTTGTGAAATGTTAGGCAACGAACAGCAGCAGGAAGACCTGGAA
AAAGATTCAAAATTATGCCCAATAGAGCCTGACAAGTCTGAATTGGAAAACTCAGGATTT
GACAGAATGAGCGAAGAAGAGCTTCTAGCAGCTGTCTTGGAGATAAGTAAGAGAGATGCT
TCACCATCTCTGAGTCATGAAGATGATGATAAGCCAACTAGCAGCCCAGATACCGGATTT
GCAGAAGATGATATTCAAGAAATGCCAGAAAATCCAGACACTATGGAAACTGAGAAGCCC
AAAACAATCACAGAGCTGGATCCTGCCAGTTTTACTGAGATAACTAAAGACTGTGATGAG
AATAAAGAAAACAAAACTCCAGAAGGATCTCAGGGAGAAGTTGATTGGCTCCAGCAGTAT
GATATGGAGCGTGAAAGGGAAGAGCAAGAGCTTCAGCAGGCACTGGCTCAGAGCCTTCAA
GAGCAAGAGGCTTGGGAACAGAAAGAAGATGATGACCTCAAAAGAGCTACCGAGTTAAGT
CTTCAAGAGTTTAACAACTCCTTTGTGGATGCATTGGGTTCTGATGAGGACTCTGGAAAT
GAGGATGTTTTTGATATGGAGTACACAGAAGCTGAAGCTGAGGAACTGAAAAGAAATGCT
GAGACAGGAAATCTGCCTCATTCGTACCGGCTCATCAGTGTTGTCAGTCACATTGGTAGC
ACTTCTTCTTCAGGTCATTACATTAGTGATGTATATGACATTAAGAAGCAAGCGTGGTTT
ACTTACAATGACCTGGAGGTATCAAAAATCCAAGAGGCTGCCGTGCAGAGTGATCGAGAT
CGGAGTGGCTACATCTTCTTTTATATGCACAAGGAGATCTTTGATGAGCTGCTGGAAACA
GAAAAGAACTCTCAGTCACTTAGCACGGAAGTGGGGAAGACTACCCGTCAGGCCTCGTGA

Protein Properties

Number of Residues

979

Molecular Weight

110168.6

Theoretical pI

6.1

Pfam Domain Function

UCH (PF00443 )
UIM (PF02809 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Ubiquitin carboxyl-terminal hydrolase 37
MSPLKIHGPIRIRSMQTGITKWKEGSFEIVEKENKVSLVVHYNTGGIPRIFQLSHNIKNV
VLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNRLPAAMKPSQGSGSF
GAILGSRTSQKETSRQLSYSDNQASAKRGSLETKDDIPFRKVLGNPGRGSIKTVAGSGIA
RTIPSLTSTSTPLRSGLLENRTEKRKRMISTGSELNEDYPKENDSSSNNKAMTDPSRKYL
TSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDRTNVSSQTPSAKR
SLGFLPQPVPLSVKKLRCNQDYTGWNKPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSLF
SLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICNSETKKDLLKKVKNAISATAER
FSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVSGEENSPDISATRAYTCPVITNLE
FEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEK
CGGKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTENTKP
PFTLGWSAHMAISRPLKASQMVNSCITSPSTPSKKFTFKSKSSLALCLDSDSEDELKRSV
ALSQRLCEMLGNEQQQEDLEKDSKLCPIEPDKSELENSGFDRMSEEELLAAVLEISKRDA
SPSLSHEDDDKPTSSPDTGFAEDDIQEMPENPDTMETEKPKTITELDPASFTEITKDCDE
NKENKTPEGSQGEVDWLQQYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLKRATELS
LQEFNNSFVDALGSDEDSGNEDVFDMEYTEAEAEELKRNAETGNLPHSYRLISVVSHIGS
TSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFYMHKEIFDELLET
EKNSQSLSTEVGKTTRQAL

External Links

GenBank ID Protein

188497648

UniProtKB/Swiss-Prot ID

Q86T82

UniProtKB/Swiss-Prot Entry Name

UBP37_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_020935.2

GeneCard ID