Cannabis Compound Database: Showing Protein Ubiquitin carboxyl-terminal hydrolase 21 (CDBP05121)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP05121

Secondary Accession Numbers

Not Available

Name

Ubiquitin carboxyl-terminal hydrolase 21

Description

Not Available

Synonyms

Deubiquitinating enzyme 21
Ubiquitin thiolesterase 21
Ubiquitin-specific-processing protease 21

Gene Name

USP21

Protein Type

Enzyme

Biological Properties

General Function

Involved in ubiquitin thiolesterase activity

Specific Function

Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates

GO Classification

Function
hydrolase activity
ubiquitin thiolesterase activity
thiolester hydrolase activity
hydrolase activity, acting on ester bonds
catalytic activity
Process
metabolic process
catabolic process
macromolecule catabolic process
cellular macromolecule catabolic process
modification-dependent macromolecule catabolic process
modification-dependent protein catabolic process
ubiquitin-dependent protein catabolic process

Cellular Location

Nucleus

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

1q22

SNPs

USP21

Gene Sequence

>1698 bp
ATGCCCCAGGCCTCTGAGCACCGCCTGGGCCGTACCCGAGAGCCACCTGTTAATATCCAG
CCCCGAGTGGGATCCAAGCTACCATTTGCCCCCAGGGCCCGCAGCAAGGAGCGCAGAAAC
CCAGCCTCTGGGCCAAACCCCATGTTACGACCTCTGCCTCCCCGGCCAGGTCTGCCTGAT
GAACGGCTCAAGAAACTGGAGCTGGGACGGGGACGGACCTCAGGCCCTCGTCCCAGAGGC
CCCCTTCGAGCAGATCATGGGGTTCCCCTGCCTGGCTCACCACCCCCAACAGTGGCTTTG
CCTCTCCCATCTCGGACCAACTTAGCCCGTTCCAAGTCTGTGAGCAGTGGGGACTTGCGT
CCAATGGGGATTGCCTTGGGAGGGCACCGTGGCACCGGAGAGCTTGGGGCTGCACTGAGC
CGCTTGGCCCTCCGGCCTGAGCCACCCACTTTGAGACGTAGCACTTCTCTCCGCCGCCTA
GGGGGCTTTCCTGGACCCCCTACCCTGTTCAGCATACGGACAGAGCCCCCTGCTTCCCAT
GGCTCCTTCCACATGATATCCGCCCGGTCCTCTGAGCCTTTCTACTCTGATGACAAGATG
GCTCATCACACACTCCTTCTGGGCTCTGGTCATGTTGGCCTTCGAAACCTGGGAAACACG
TGCTTCCTGAATGCTGTGCTGCAGTGTCTGAGCAGCACTCGACCTCTTCGGGACTTCTGT
CTGAGAAGGGACTTCCGGCAAGAGGTGCCTGGAGGAGGCCGAGCCCAAGAGCTCACTGAA
GCCTTTGCAGATGTGATTGGTGCCCTCTGGCACCCTGACTCCTGCGAAGCTGTGAATCCT
ACTCGATTCCGAGCTGTCTTCCAGAAATATGTTCCCTCCTTCTCTGGATACAGCCAGCAG
GATGCCCAAGAGTTCCTGAAGCTCCTCATGGAGCGGCTACACCTTGAAATCAACCGCCGA
GGCCGCCGGGCTCCACCGATACTTGCCAATGGTCCAGTTCCCTCTCCACCCCGCCGAGGA
GGGGCTCTGCTAGAAGAACCTGAGTTAAGTGATGATGACCGAGCCAACCTAATGTGGAAA
CGTTACCTGGAGCGAGAGGACAGCAAGATTGTGGACCTGTTTGTGGGCCAGTTGAAAAGT
TGTCTCAAGTGCCAGGCCTGTGGGTATCGCTCCACGACCTTCGAGGTTTTTTGTGACCTG
TCCCTGCCCATCCCCAAGAAAGGATTTGCTGGGGGCAAGGTGTCTCTGCGGGATTGTTTC
AACCTTTTCACTAAGGAAGAAGAGCTAGAGTCGGAGAATGCCCCAGTGTGTGACCGATGT
CGGCAGAAAACTCGAAGTACCAAAAAGTTGACAGTACAAAGATTCCCTCGAATCCTCGTG
CTCCATCTGAATCGATTTTCTGCCTCCCGAGGCTCCATCAAAAAAAGTTCAGTAGGTGTA
GACTTTCCACTGCAGCGACTGAGCCTAGGGGACTTTGCCAGTGACAAAGCCGGAAGTCCT
GTATACCAGCTGTATGCCCTTTGCAACCACTCAGGCAGCGTCCACTATGGCCACTACACA
GCCCTGTGCCGGTGCCAGACTGGTTGGCATGTCTACAATGACTCTCGTGTCTCCCCTGTC
AGTGAAAACCAGGTGGCATCCAGCGAGGGCTACGTGCTGTTCTACCAACTGATGCAGGAG
CCACCCCGGTGCCTGTGA

Protein Properties

Number of Residues

565

Molecular Weight

62655.1

Theoretical pI

10.37

Pfam Domain Function

UCH (PF00443 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Ubiquitin carboxyl-terminal hydrolase 21
MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPD
ERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLR
PMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASH
GSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFC
LRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQ
DAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWK
RYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCF
NLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGV
DFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPV
SENQVASSEGYVLFYQLMQEPPRCL

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

Q9UK80

UniProtKB/Swiss-Prot Entry Name

UBP21_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF177758

GeneCard ID