| Identification |
|---|
| HMDB Protein ID
| CDBP05119 |
| Secondary Accession Numbers
| Not Available |
| Name
| L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase |
| Description
| Not Available |
| Synonyms
|
- 4'-phosphopantetheinyl transferase
- AASD-PPT
- Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase
- LYS5 ortholog
|
| Gene Name
| AASDHPPT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in magnesium ion binding |
| Specific Function
| Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.
|
| GO Classification
|
| Biological Process |
| macromolecule biosynthetic process |
| pantothenate metabolic process |
| Cellular Component |
| cytosol |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| magnesium ion binding |
| phosphotransferase activity, for other substituted phosphate groups |
| holo-[acyl-carrier-protein] synthase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| Molecular Function |
| magnesium ion binding |
| holo-[acyl-carrier-protein] synthase activity |
| Process |
| macromolecule biosynthetic process |
| metabolic process |
| biosynthetic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11q22 |
| SNPs
| AASDHPPT |
| Gene Sequence
|
>930 bp
ATGGTTTTCCCTGCCAAACGGTTCTGCTTGGTGCCATCCATGGAGGGCGTGCGCTGGGCC
TTTTCCTGCGGCACTTGGCTGCCGAGCCGAGCCGAATGGCTGCTGGCAGTGCGATCGATT
CAGCCCGAGGAGAAGGAGCGCATTGGCCAGTTCGTCTTTGCCCGGGACGCTAAGGCAGCC
ATGGCTGGTCGTCTGATGATAAGGAAATTAGTTGCAGAGAAATTGAATATCCCTTGGAAT
CATATTCGTTTGCAAAGAACTGCAAAAGGAAAACCAGTTCTTGCAAAGGACTCATCGAAT
CCATACCCGAATTTCAACTTTAACATCTCTCATCAAGGAGACTATGCAGTGCTTGCTGCT
GAACCTGAGCTGCAAGTTGGAATTGATATAATGAAGACTAGTTTTCCAGGTCGTGGTTCA
ATTCCAGAATTCTTTCATATTATGAAAAGAAAGTTTACCAACAAAGAATGGGAAACAATC
AGAAGCTTTAAGGATGAGTGGACTCAGCTGGATATGTTTTATAGGAATTGGGCACTTAAG
GAAAGCTTCATAAAAGCCATTGGTGTTGGACTAGGATTTGAATTGCAGCGGCTTGAATTT
GATCTATCTCCATTAAACTTGGATATAGGCCAAGTTTATAAAGAAACACGTTTATTCCTG
GATGGAGAGGAAGAAAAAGAATGGGCATTTGAGGAAAGCAAAATAGATGAGCACCATTTT
GTTGCAGTTGCTCTTAGGAAACCCGACGGATCTAGACATCAGGATGTTCCATCTCAGGAT
GATTCCAAACCAACCCAGAGGCAATTTACTATTCTCAACTTTAATGATTTAATGTCATCT
GCCGTTCCCATGACACCTGAAGATCCTTCATTTTGGGACTGTTTTTGCTTCACAGAAGAA
ATTCCAATACGAAATGGTACAAAGTCATGA
|
| Protein Properties |
|---|
| Number of Residues
| 309 |
| Molecular Weight
| 35775.64 |
| Theoretical pI
| 6.805 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
MVFPAKRFCLVPSMEGVRWAFSCGTWLPSRAEWLLAVRSIQPEEKERIGQFVFARDAKAA
MAGRLMIRKLVAEKLNIPWNHIRLQRTAKGKPVLAKDSSNPYPNFNFNISHQGDYAVLAA
EPELQVGIDIMKTSFPGRGSIPEFFHIMKRKFTNKEWETIRSFKDEWTQLDMFYRNWALK
ESFIKAIGVGLGFELQRLEFDLSPLNLDIGQVYKETRLFLDGEEEKEWAFEESKIDEHHF
VAVALRKPDGSRHQDVPSQDDSKPTQRQFTILNFNDLMSSAVPMTPEDPSFWDCFCFTEE
IPIRNGTKS
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9NRN7 |
| UniProtKB/Swiss-Prot Entry Name
| ADPPT_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF302110 |
| GeneCard ID
| AASDHPPT |
| GenAtlas ID
| AASDHPPT |
| HGNC ID
| HGNC:14235 |
| References |
|---|
| General References
| Not Available |