Cannabis Compound Database: Showing Protein E3 ubiquitin-protein ligase MIB1 (CDBP05112)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP05112

Secondary Accession Numbers

Not Available

Name

E3 ubiquitin-protein ligase MIB1

Description

Not Available

Synonyms

DAPK-interacting protein 1
DIP-1
Mind bomb homolog 1
Zinc finger ZZ type with ankyrin repeat domain protein 2

Gene Name

MIB1

Protein Type

Enzyme

Biological Properties

General Function

Involved in ubiquitin-protein ligase activity

Specific Function

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF- induced apoptosis

GO Classification

Function
acid-amino acid ligase activity
ubiquitin-protein ligase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
small conjugating protein ligase activity
transition metal ion binding
zinc ion binding
ligase activity
protein binding
ligase activity, forming carbon-nitrogen bonds
Process
metabolic process
macromolecule metabolic process
protein modification by small protein conjugation or removal
protein modification by small protein conjugation
protein ubiquitination
macromolecule modification
protein modification process

Cellular Location

Cell membrane
Cytoplasm

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

18q11.2

SNPs

MIB1

Gene Sequence

>3021 bp
ATGAGTAACTCCCGGAATAACCGGGTGATGGTGGAAGGGGTTGGCGCTCGGGTAGTGCGC
GGCCCGGACTGGAAGTGGGGGAAGCAGGACGGCGGCGAGGGCCATGTGGGCACCGTCCGG
AGCTTCGAGAGCCCCGAGGAGGTGGTGGTAGTGTGGGACAACGGCACAGCTGCCAACTAC
CGCTGCTCCGGGGCTTACGACCTCCGCATCCTGGACAGCGCGCCCACCGGCATCAAGCAT
GATGGAACCATGTGTGATACCTGCCGCCAGCAACCAATCATTGGCATTCGATGGAAGTGT
GCAGAGTGTACAAATTATGATTTGTGCACAGTGTGTTATCATGGAGATAAACATCATTTA
AGACATCGCTTTTACCGAATTACTACACCGGGAAGTGAGAGGGTTCTGTTAGAGTCTCGT
AGGAAATCTAAGAAGATTACAGCCAGAGGAATCTTTGCAGGTGCCAGAGTGGTGCGAGGA
GTGGACTGGCAGTGGGAAGATCAAGATGGAGGAAATGGACGTAGGGGAAAGGTAACAGAA
ATCCAGGACTGGAGTGCATCAAGCCCACATAGCGCAGCATATGTCCTCTGGGATAATGGT
GCTAAGAACCTTTACAGAGTTGGCTTTGAGGGCATGTCTGATCTGAAATGTGTCCAGGAT
GCCAAGGGAGGTTCTTTCTACAGAGATCACTGCCCTGTGCTAGGTGAGCAGAATGGCAAC
AGGAATCCTGGTGGATTGCAGATTGGTGACCTGGTAAATATAGATCTCGACCTCGAAATT
GTACAGTCTTTGCAGCATGGTCATGGAGGATGGACTGATGGAATGTTTGAGACTTTAACT
ACAACTGGAACTGTTTGTGGCATTGATGAAGATCATGACATTGTAGTACAGTATCCAAGT
GGCAATAGGTGGACCTTCAATCCTGCTGTTCTCACTAAAGCGAACATTGTCCGAAGTGGA
GATGCTGCTCAGGGTGCAGAAGGAGGCACCTCGCAGTTTCAAGTGGGTGATCTTGTACAA
GTTTGTTATGACCTGGAACGAATTAAACTTCTACAAAGAGGACATGGAGAATGGGCTGAA
GCGATGCTTCCAACTTTAGGTAAAGTTGGCCGAGTACAACAGATTTATTCAGACAGTGAT
TTAAAGGTGGAAGTTTGTGGAACATCTTGGACATACAATCCAGCAGCAGTTTCCAAGGTG
GCATCTGCAGGATCAGCCATTAGCAATGCATCTGGTGAAAGACTCTCACAACTCCTGAAG
AAATTATTTGAAACCCAAGAATCTGGTGACCTCAATGAAGAATTAGTTAAGGCTGCTGCC
AATGGAGATGTTGCTAAAGTGGAAGATTTGCTTAAAAGACCAGATGTGGATGTAAATGGG
CAATGTGCTGGCCACACAGCTATGCAAGCTGCTAGTCAGAATGGACATGTTGACATTTTG
AAGTTACTTTTGAAGCAAAACGTGGATGTCGAAGCAGAGGATAAAGATGGTGATAGAGCA
GTTCACCATGCAGCTTTTGGAGATGAAGGCGCTGTTATAGAAGTACTACATCGAGGTAGT
GCTGATTTGAATGCTCGAAACAAGCGCCGACAGACACCACTTCATATTGCTGTCAATAAA
GGTCATCTTCAAGTTGTGAAGACTTTATTGGACTTTGGCTGTCATCCCAGTCTCCAGGAT
TCTGAAGGTGATACCCCTCTTCATGATGCAATAAGTAAGAAACGTGATGATATCCTAGCA
GTTCTTTTGGAAGCTGGAGCAGATGTTACCATCACAAACAATAATGGATTTAATGCTCTG
CATCATGCTGCACTAAGGGGAAATCCCAGTGCAATGCGTGTTTTACTATCTAAATTACCA
AGACCATGGATTGTGGATGAGAAGAAAGATGATGGTTATACTGCCTTACATCTGGCTGCC
CTTAATAATCACGTAGAAGTGGCTGAACTGTTGGTACATCAGGGTAATGCAAACCTGGAT
ATCCAGAATGTGAACCAACAAACTGCCCTACACCTTGCTGTTGAACGACAGCATACCCAG
ATTGTTAGGCTTTTGGTCCGTGCAGGTGCCAAGCTTGATATTCAGGATAAGGATGGGGAT
ACTCCTTTGCATGAAGCTCTAAGGCATCACACTTTGTCTCAGCTACGTCAGCTCCAAGAT
ATGCAAGATGTGGGGAAGGTGGATGCTGCCTGGGAGCCATCCAAAAACACGTTAATAATG
GGACTTGGTACCCAGGGGGCAGAGAAGAAGAGTGCAGCATCTATTGCCTGTTTCTTGGCA
GCCAATGGTGCTGACCTGAGCATTCGAAATAAGAAGGGTCAATCGCCACTTGATCTCTGT
CCTGATCCGAATCTCTGCAAAGCACTGGCAAAGTGTCATAAGGAAAAAGTCAGTGGTCAA
GTGGGTTCTCGGAGTCCTTCTATGATTAGTAATGATTCTGAAACCTTAGAAGAGTGTATG
GTGTGCTCAGATATGAAGAGAGATACTCTTTTTGGTCCATGTGGACATATTGCTACCTGT
TCTTTATGTTCTCCACGTGTCAAGAAATGCCTCATCTGTAAAGAACAGGTTCAATCCAGG
ACAAAGATTGAAGAATGTGTGGTATGCTCTGACAAGAAAGCAGCTGTTCTTTTTCAACCC
TGTGGCCACATGTGTGCTTGTGAGAACTGTGCTAACCTGATGAAAAAGTGTGTGCAGTGT
CGAGCAGTAGTTGAACGAAGAGTGCCTTTCATTATGTGCTGTGGAGGGAAAAGTTCAGAA
GATGCCACTGATGATATCTCAAGTGGGAATATTCCAGTATTACAAAAGGACAAGGATAAT
ACCAATGTCAATGCAGATGTGCAAAAGTTGCAGCAACAGTTACAAGACATTAAAGAGCAG
ACAATGTGCCCTGTGTGTCTAGATCGTCTGAAGAATATGATTTTCCTTTGTGGTCACGGA
ACCTGTCAACTCTGTGGAGACCGCATGAGTGAATGTCCTATCTGTCGCAAGGCTATTGAA
CGAAGGATTCTTTTGTATTAA

Protein Properties

Number of Residues

1006

Molecular Weight

110135.1

Theoretical pI

6.9

Pfam Domain Function

ZZ (PF00569 )
Ank (PF00023 )
MIB_HERC2 (PF06701 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>E3 ubiquitin-protein ligase MIB1
MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANY
RCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHL
RHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTE
IQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGN
RNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPS
GNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAE
AMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLK
KLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDIL
KLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNK
GHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNAL
HHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLD
IQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQD
MQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC
PDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHIATC
SLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQC
RAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQ
TMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

Q86YT6

UniProtKB/Swiss-Prot Entry Name

MIB1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AY149908

GeneCard ID