| Identification |
|---|
| HMDB Protein ID
| CDBP05090 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rho guanine nucleotide exchange factor 17 |
| Description
| Not Available |
| Synonyms
|
- 164 kDa Rho-specific guanine-nucleotide exchange factor
- Tumor endothelial marker 4
- p164-RhoGEF
- p164RhoGEF
|
| Gene Name
| ARHGEF17 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in Rho guanyl-nucleotide exchange factor activity |
| Specific Function
| Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| small gtpase regulator activity |
| ras guanyl-nucleotide exchange factor activity |
| rho guanyl-nucleotide exchange factor activity |
| enzyme regulator activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| Process |
| regulation of cellular process |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
| regulation of ras protein signal transduction |
| regulation of rho protein signal transduction |
| biological regulation |
| regulation of biological process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q13.4 |
| SNPs
| ARHGEF17 |
| Gene Sequence
|
>6192 bp
ATGGCGGACGGGGCACCCCGGCCCCAGCTTTACCGCAGCGTCTCGTTCAAGCTGCTGGAG
CGCTGGAGCGGCGGCCCCGGGCTGAGGGAGGAGGACACGGACACCCCCGGCTTGAGGCGA
CGCGCCTCGTGCCGGCCGACCACGGCTGCCCGGGGCCAGCCCTCTCGGCGCGTGTCCAAG
CTGGCGTCTGGGCCCCTGGCCGCCCCCGCGCAGCCGCGCCCGCTCCGCAGCCTCTCGCCG
TCGGTTCGCCAGCTCTCCCGGCGCTTCGACGCGCCGCGTCTGGACGACGGCTCCGCTGGG
ACCCGAGACGGAGGCGTCTTACCCGCGGCCGCGGAAGAAGCGGCCGAGGGCCCAGCGCGA
GGAGCCTGGCCCAGCGTCACCGAGATGCGCAAGCTCTTCGGCGGTCCTGGCTCCAGGAGG
CCCAGCGCCGACTCTGAATCCCCAGGAACGCCCAGCCCCGACGGTGCCGCGTGGGAGCCT
CCGGCTCGGGAGTCGCGGCAGCCACCGACGCCACCCCCTCGGACATGCTTCCCCCTGGCG
GGTCTGCGTTCGGCGCGGCCCCTGACCGGGCCGGAGACCGAAGGGAGGCTGCGCCGGCCG
CAGCAGCAACAGGAGCGGGCGCAGCGTCCAGCGGATGGTTTACATTCTTGGCATATCTTC
TCCCAACCGCAGGCCGGGGCCCGGGCCTCCTGCTCCTCCTCCTCCATCGCCGCCTCCTAT
CCTGTCAGCCGCAGTCGTGCTGCCAGCTCCAGCGAGGAGGAAGAGGAGGGCCCGCCGCAG
CTGCCTGGAGCCCAGAGTCCGGCCTACCACGGCGGCCACTCCTCGGGCAGTGACGACGAC
CGAGACGGTGAGGGCGGCCACCGCTGGGGAGGGAGGCCCGGGCTCAGGCCTGGAAGCTCC
CTATTGGATCAGGACTGCAGGCCTGACAGTGATGGGTTAAATCTAAGCAGCATGAACTCA
GCAGGGGTTTCTGGGAGCCCTGAGCCCCCAACATCTCCAAGAGCCCCTAGAGAAGAAGGA
CTCCGGGAGTGGGGTAGTGGCTCTCCGCCCTGCGTCCCAGGTCCCCAGGAGGGACTTCGG
CCTATGTCTGACTCTGTGGGAGGAGCTTTCCGTGTGGCCAAGGTGAGCTTTCCCTCGTAC
CTGGCCAGCCCCGCAGGCTCCCGCGGTAGCAGCCGTTATTCCAGCACGGAGACCCTCAAG
GACGACGACCTATGGTCTAGTAGGGGTTCTGGGGGCTGGGGCGTGTACCGCTCCCCTAGC
TTTGGAGCTGGGGAAGGGCTCCTGCGGTCCCAGGCTCGAACCCGTGCCAAAGGACCTGGA
GGCACCTCTAGGGCATTGAGGGATGGAGGATTTGAGCCTGAAAAGAGTCGACAGCGGAAG
TCCCTGTCAAATCCAGATATCGCCTCAGAGACCCTGACGCTTCTCAGTTTCCTGCGCTCA
GACCTTTCAGAGCTGAGGGTCCGAAAACCTGGTGGGAGCTCCGGGGACCGTGGAAGCAAC
CCCCTAGATGGCAGAGACTCACCATCCGCAGGTGGCCCTGTGGGGCAACTTGAACCCATA
CCCATCCCAGCCCCAGCATCACCTGGCACGCGCCCCACACTCAAGGACTTGACAGCCACT
CTGCGGAGAGCAAAGTCATTCACCTGCTCTGAGAAGCCCATGGCCCGCCGCCTGCCCCGC
ACCAGTGCTCTGAAGTCCAGCTCCTCCGAGCTCCTGCTCACAGGCCCTGGTGCCGAGGAG
GATCCGCTGCCCCTCATCGTCCAGGACCAATATGTGCAGGAGGCCCGCCAGGTTTTTGAG
AAGATCCAGCGCATGGGTGCCCAACAAGATGATGGAAGCGATGCCCCCCCTGGAAGCCCT
GACTGGGCAGGGGATGTGACCCGAGGGCAGCGGTCCCAGGAGGAGCTCTCAGGCCCTGAG
TCCAGTCTGACAGATGAAGGCATTGGGGCAGACCCTGAGCCTCCTGTTGCAGCATTTTGC
GGCCTGGGTACCACAGGGATGTGGCGACCTCTTTCCTCATCCTCGGCCCAGACGAACCAC
CATGGCCCTGGGACTGAGGACAGTCTGGGCGGGTGGGCCCTGGTGTCGCCTGAGACCCCT
CCCACACCAGGTGCCCTCCGCCGACGACGCAAAGTCCCACCTTCAGGTTCTGGTGGGAGC
GAATTGAGCAATGGGGAGGCAGGGGAGGCCTACAGGTCCCTGAGTGACCCAATTCCTCAG
CGCCACCGGGCTGCCACCTCTGAAGAGCCTACTGGGTTCTCTGTGGACAGCAACCTCCTG
GGCTCACTGAGCCCCAAGACAGGGCTCCCTGCCACCTCAGCCATGGATGAGGGCTTGACC
AGTGGTCACAGTGACTGGTCTGTGGGCAGTGAAGAGAGCAAGGGATATCAGGAGGTTATT
CAGAGCATAGTTCAGGGGCCTGGCACCCTGGGGCGTGTGGTGGACGACAGGATTGCTGGC
AAAGCCCCCAAGAAGAAATCCCTGAGTGACCCCAGCCGCCGTGGGGAGCTGGCTGGGCCT
GGATTCGAGGGCCCTGGAGGGGAGCCCATCCGAGAAGTTGAGCCCATGCTGCCTCCATCC
AGCAGCGAGCCCATCCTTGTAGAGCAGCGGGCAGAGCCAGAAGAACCTGGTGCCACCAGG
AGCCGGGCACAGTCTGAAAGGGCCCTACCTGAGGCTCTGCCTCCCCCTGCCACTGCCCAC
CGAAACTTTCACCTTGACCCCAAGCTGGCTGACATTCTGTCCCCGAGGCTAATCCGCCGA
GGCTCCAAGAAGCGCCCAGCTCGGAGTAGTCACCAGGAGCTTCGGAGAGACGAGGGCAGT
CAGGACCAGACTGGCAGCCTGTCTCGGGCCCGGCCCTCCTCCAGACACGTTCGCCATGCC
AGTGTGCCCGCCACATTTATGCCTATTGTGGTGCCTGAGCCACCAACTTCTGTTGGTCCC
CCTGTGGCTGTGCCAGAACCCATAGGCTTCCCTACCCGAGCCCATCCCACGTTGCAGGCA
CCATCGCTCGAGGACGTCACCAAGCAGTACATGCTGAACCTGCACTCCGGTGAGGTCCCT
GCCCCAGTGCCAGTGGACATGCCCTGCTTGCCTCTGGCTGCACCGCCCTCTGCTGAGGCC
AAGCCCCCTGAGGCAGCTCGGCCTGCAGATGAGCCTACCCCTGCCAGCAAGTGCTGCAGC
AAGCCACAGGTGGACATGCGGAAGCACGTGGCCATGACCCTGCTGGACACAGAGCAGTCG
TATGTGGAGTCGCTGCGCACCCTGATGCAGGGCTACATGCAGCCGCTGAAGCAGCCAGAG
AACTCCGTGCTCTGTGACCCTTCACTGGTGGACGAGATCTTCGACCAGATCCCCGAGCTC
CTGGAGCACCACGAGCAATTCCTGGAGCAGGTTCGGCACTGCATGCAGACCTGGCATGCC
CAGCAGAAGGTGGGAGCCCTGCTCGTCCAGTCGTTCTCCAAGGATGTCCTAGTAAACATC
TATTCTGCCTATATCGATAACTTCCTCAATGCAAAGGATGCTGTGCGTGTGGCCAAGGAG
GCGAGGCCTGCCTTTCTCAAGTTCCTAGAGCAAAGCATGCGTGAGAACAAGGAGAAGCAG
GCGCTGTCTGACCTCATGATCAAGCCTGTGCAGCGGATCCCACGCTACGAGCTTCTGGTG
AAGGACCTCCTGAAGCATACACCTGAGGACCACCCGGACCATCCACTCCTGCTGGAGGCG
CAGCGGAACATCAAGCAGGTGGCTGAGCGCATCAACAAGGGTGTGCGGAGTGCCGAGGAG
GCGGAGCGCCATGCCCGTGTGCTGCAGGAGATAGAGGCTCACATCGAGGGCATGGAGGAT
CTCCAGGCCCCTCTGCGGCGGTTCCTGAGACAGGAGATGGTCATTGAAGTGAAGGCGATC
GGTGGCAAGAAGGACCGGTCTCTCTTCCTGTTCACGGACCTCATCGTCTGCACCACTCTG
AAGCGAAAGTCAGGCTCCCTGCGGCGCAGCTCCATGAGCCTGTACACGGCAGCCAGTGTC
ATTGACACAGCCAGCAAGTACAAGATGCTGTGGAAGCTGCCGCTGGAAGACGCAGACATC
ATCAAAGGGGCATCCCAAGCCACCAATCGGGAGAACATCCAGAAGGCCATCAGCCGCCTT
GATGAGGACCTCACCACCCTGGGCCAAATGAGCAAGCTCTCTGAGAGCCTTGGTTTCCCC
CACCAGAGCCTGGACGATGCACTGCGGGACCTCTCAGCTGCCATGCACCGGGACCTGTCG
GAGAAGCAGGCGCTGTGCTACGCGCTTTCCTTCCCGCCAACCAAGCTGGAGCTGTGCGCC
ACTCGGCCCGAGGGCACCGACTCCTACATTTTTGAGTTCCCTCACCCTGACGCCCGCCTT
GGTTTTGAACAGGCCTTCGATGAGGCCAAGAGGAAGCTGGCATCCAGCAAAAGCTGTCTA
GACCCTGAGTTCCTGAAGGCCATCCCCATCATGAAAACCCGCAGTGGCATGCAGTTCTCC
TGTGCGGCTCCCACCCTGAACAGCTGCCCGGAGCCCTCGCCTGAGGTATGGGTCTGCAAC
AGCGACGGCTACGTGGGCCAGGTGTGCCTGCTGAGCCTGCGCGCCGAGCCGGACGTGGAG
GCCTGCATCGCCGTCTGTTCCGCCCGCATCCTCTGCATCGGGGCGGTGCCCGGGCTGCAG
CCTCGCTGCCACCGGGAGCCTCCTCCGTCGCTGAGGAGTCCTCCAGAGACGGCACCGGAG
CCCGCCGGGCCGGAGCTGGACGTCGAGGCCGCTGCAGACGAGGAAGCCGCGACGCTCGCG
GAGCCGGGGCCGCAGCCCTGCCTTCACATCTCCATTGCAGGCTCGGGCTTGGAGATGACG
CCGGGCCTCGGCGAGGGTGACCCCCGCCCAGAGCTGGTGCCCTTTGACAGTGACTCTGAC
GATGAGTCTTCGCCCAGCCCCTCGGGGACGCTGCAGAGCCAGGCCAGCCGGTCCACCATC
TCCTCCAGCTTTGGCAATGAGGAGACCCCGAGTTCCAAGGAGGCCACGGCAGAGACCACC
AGCTCAGAGGAGGAGCAGGAGCCAGGCTTCCTGCCACTGTCTGGCTCCTTTGGGCCTGGT
GGTCCCTGCGGCACCAGCCCAATGGATGGGAGAGCCCTTCGCCGCTCCAGCCACGGCTCC
TTCACCCGGGGCAGCCTTGAGGACCTGCTGAGTGTCGACCCTGAGGCCTACCAGAGCTCC
GTGTGGCTGGGCACTGAGGATGGCTGTGTCCACGTGTACCAGTCCTCCGACAGCATCCGT
GACCGCAGGAACAGCATGAAGCTCCAGCATGCGGCCTCTGTGACCTGCATCTTGTATCTG
AATAACCAGGTGTTTGTGTCTCTGGCCAATGGAGAGCTTGTGGTCTACCAAAGGGAAGCA
GGCCATTTCTGGGACCCCCAGAACTTCAAATCAGTGACCTTGGGCACCCAGGGGAGCCCC
ATCACCAAGATGGTATCTGTGGGTGGGCGGCTGTGGTGTGGCTGCCAGAACCGAGTCCTT
GTCCTGAGCCCTGACACGCTGCAGCTGGAGCACATGTTTTACGTGGGTCAGGATTCAAGC
CGCTGCGTGGCTTGCATGGTGGACTCCAGCCTGGGTGTGTGGGTGACATTGAAAGGTAGT
GCCCACGTGTGTCTCTACCATCCAGACACCTTTGAGCAGCTGGCAGAAGTAGACGTCACT
CCTCCCGTGCACAGGATGCTGGCAGGCTCGGATGCCATCATCCGGCAGCACAAGGCTGCC
TGTCTGCGAATCACAGCGCTGCTGGTGTGTGAGGAGCTGCTGTGGGTGGGCACCAGTGCT
GGTGTCGTCCTCACCATGCCCACTTCGCCCGGTACTGTCAGCTGCCCACGGGCACCACTC
AGTCCCACAGGCCTCGGCCAGGGACACACCGGCCACGTCCGCTTCTTGGCTGCAGTCCAG
CTGCCAGATGGCTTCAACCTGCTCTGCCCAACCCCACCACCTCCCCCAGACACAGGCCCC
GAGAAGCTGCCATCACTGGAGCACCGGGACTCCCCTTGGCACCGAGGCCCCGCCCCTGCC
AGGCCTAAAATGCTGGTTATCAGTGGAGGTGATGGCTATGAGGACTTCCGACTCAGCAGT
GGGGGCGGCAGCAGCAGTGAGACTGTGGGTCGAGACGACAGCACAAACCACCTCCTCCTG
TGGAGGGTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 2063 |
| Molecular Weight
| 221670.1 |
| Theoretical pI
| 6.22 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rho guanine nucleotide exchange factor 17
MADGAPRPQLYRSVSFKLLERWSGGPGLREEDTDTPGLRRRASCRPTTAARGQPSRRVSK
LASGPLAAPAQPRPLRSLSPSVRQLSRRFDAPRLDDGSAGTRDGGVLPAAAEEAAEGPAR
GAWPSVTEMRKLFGGPGSRRPSADSESPGTPSPDGAAWEPPARESRQPPTPPPRTCFPLA
GLRSARPLTGPETEGRLRRPQQQQERAQRPADGLHSWHIFSQPQAGARASCSSSSIAASY
PVSRSRAASSSEEEEEGPPQLPGAQSPAYHGGHSSGSDDDRDGEGGHRWGGRPGLRPGSS
LLDQDCRPDSDGLNLSSMNSAGVSGSPEPPTSPRAPREEGLREWGSGSPPCVPGPQEGLR
PMSDSVGGAFRVAKVSFPSYLASPAGSRGSSRYSSTETLKDDDLWSSRGSGGWGVYRSPS
FGAGEGLLRSQARTRAKGPGGTSRALRDGGFEPEKSRQRKSLSNPDIASETLTLLSFLRS
DLSELRVRKPGGSSGDRGSNPLDGRDSPSAGGPVGQLEPIPIPAPASPGTRPTLKDLTAT
LRRAKSFTCSEKPMARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFE
KIQRMGAQQDDGSDAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFC
GLGTTGMWRPLSSSSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGS
ELSNGEAGEAYRSLSDPIPQRHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLT
SGHSDWSVGSEESKGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGP
GFEGPGGEPIREVEPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAH
RNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHA
SVPATFMPIVVPEPPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVP
APVPVDMPCLPLAAPPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQS
YVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHA
QQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQ
ALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEE
AERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTL
KRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRL
DEDLTTLGQMSKLSESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCA
TRPEGTDSYIFEFPHPDARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFS
CAAPTLNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQ
PRCHREPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMT
PGLGEGDPRPELVPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETT
SSEEEQEPGFLPLSGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSS
VWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREA
GHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSS
RCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAA
CLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQGHTGHVRFLAAVQ
LPDGFNLLCPTPPPPPDTGPEKLPSLEHRDSPWHRGPAPARPKMLVISGGDGYEDFRLSS
GGGSSSETVGRDDSTNHLLLWRV
|
| External Links |
|---|
| GenBank ID Protein
| 21361458 |
| UniProtKB/Swiss-Prot ID
| Q96PE2 |
| UniProtKB/Swiss-Prot Entry Name
| ARHGH_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_014786.3 |
| GeneCard ID
| ARHGEF17 |
| GenAtlas ID
| ARHGEF17 |
| HGNC ID
| HGNC:21726 |
| References |
|---|
| General References
| Not Available |