| Identification |
|---|
| HMDB Protein ID
| CDBP05088 |
| Secondary Accession Numbers
| Not Available |
| Name
| IQ motif and SEC7 domain-containing protein 3 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| IQSEC3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ARF guanyl-nucleotide exchange factor activity |
| Specific Function
| Acts as a guanine nucleotide exchange factor (GEF) for ARF1 |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| small gtpase regulator activity |
| enzyme regulator activity |
| arf guanyl-nucleotide exchange factor activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| Process |
| regulation of biological process |
| regulation of arf protein signal transduction |
| regulation of cellular process |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
| regulation of ras protein signal transduction |
| biological regulation |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12p13.33 |
| SNPs
| IQSEC3 |
| Gene Sequence
|
>3549 bp
ATGGAGAGCCTGCTGGAGAATCCGGTGCGCGCCGTGCTCTACCTCAAGGAGCTCACGGCC
ATCGTGCAGAACCAGCAGAGCCTCATCCACACCCAGCGAGAGCGTATCGACGAGCTGGAG
CGGCGGCTGGACGAGCTGAGCGCTGAGAACCGCAGCCTGTGGGAGCACCAGCAGCTGCTG
CAAGCCCAGCCTCCGCCCGGGCTCGTCCCCCCGTCATCGGCCCCGCTGCCGGCCGCTCCG
GCCACCGCTCCTGCCGCCGCCGCCAGGGCCCAGGAACCTCTCCAGGACCAGGGACAGCGC
TCAGCAGCCGCGCCGCATCCCGCGCCCGATCGGCCGCCGCGTCAGCACCACGGACAGCTC
CTGGAGCAGCCCCAGCGGGGCCCTGGCAGCAGGGCTCACACACCCCAGTCGCCCCACAAG
CATCTGGGGACACAAGGGGCCGTGACTGACAAGGAGAAGGAGCGTCCCCCGAGTTGCTGC
GCTGCTGCCGGAGCCCTCCTTCAGCACAAATCCCCCTCCGCCCTCGGCAAGGGCGTCCTG
AGCAGGAGACCTGAGAATGAGACCGTGCTGCACCAGTTCTGCTGCCCAGCCGCCGACGCC
TGCTCCGACCTGGCCTCCCAAAGTGATGGCTCCTGCACCCAGGCCGGTGGGGGCATGGAG
GACTCCGTGGTGGCAGCGGCGGCGGTGGCAGCCGGCAGACCCAGTGCCCATGCCCCGAAG
GCTCAAGCCCAGGAGCTGCAGGAGGAGGAGGAGCGGCCGGGGGCAGGGGCTGCCTCCCCA
AGGGCTGGCCCCCAGCACAAGGCCTCCCCCGGCCGGCAGCAGCCTGCCCTGGCGACGGCG
CTGTGCCCCCACGCCCCTGCCGCCTCCGATTACGAACTCTCCCTTGACCTAAAGAATAAA
CAGATTGAAATGCTAGAACATAAGTACGGCGGTCACCTGGTGTCCCGGCGCGCCGCTTGC
ACCATCCAAACCGCCTTCCGCCAATACCAGCTCAGCAAGAACTTCGAGAAAATCCGCAAC
TCGCTTCTGGAGAGCCGCCTGCCACGGCGGATCTCCCTGCGCAAGGTGCGGTCACCCACG
GCCGAGAGCCTGGCGGCCGAGAAAGCGCTCATGGAGGGCTACGGCCTCGTGGGGCTGCCG
CTGGTGCGCTCGCCCTCCCTGCCGCCCACCTTCGCAGGCACCCTCACCGAGCTGGAGGAC
TCCTTCACCGAGCAGGTGCAATCCCTGGCCAAGTCCATCGACGACGCGCTCAGCACGTGG
AGCCTCAAGACCATGTGCTCCCTGCGGGAGAGTGGCGCTTACCAGCTCCACCAGGCCCTG
CAGGCGGCCGCGGGGCCCCCAGGCCTGGAGGCCGAGGGGCGGGCGCCGGAGAGCGCGGGC
CCCGGGCCCGGGGATGACGCCGCGGAGACCCCCGGCCTGCCCCCGGCCCACAGCGGGACC
CTCATGATGGCTTTCCGGGACGTCACGGTGCAGATCGCCAACCAGAACATATCCGTCTCC
TCCTCCACGGCTCTGTCGGTGGCCAACTGCCTGGGCGCTCAGACGGTCCAGGCCCCCGCA
GAGCCCGCGGCGGGCAAGGCCGAGCAGGGCGAGACCTCTGGGCGGGAGGCCCCGGAAGCC
CCCGCCGTGGGCCGGGAGGACGCGTCAGCCGAGGACTCATGCGCAGAGGCTGCGGCTAGT
GGGGCGGCGGATGGGGCCACAGCCCCCAAAACAGAGGAGGAAGAGGAGGAGGAGGAGACG
GCGGAGGTGGGGAGAGGGGCCGAGGCCGAGGCAGGCGACTTGGAGCAGCTGAGCAGCAGC
AGCACGTCCACCAAGTCCGCCAAGTCAGGCTCGGAGGCGTCGGCCTCCGCCTCCAAGGAC
GCCCTGCAGGCCATGATCCTGAGCCTGCCGCGCTACCACTGCGAGAACCCAGCCAGCTGC
AAGTCGCCCACGCTCTCCACCGACACCCTGCGCAAGCGGCTCTACCGCATCGGCCTCAAC
CTCTTCAACATAAACCCCGACAAGGGCATCCAGTTCCTGATCTCACGCGGCTTCATCCCG
GACACCCCCATCGGTGTGGCCCATTTCCTCCTCCAGCGAAAGGGCCTCAGCCGCCAGATG
ATTGGAGAGTTCCTGGGCAACAGCAAGAAGCAGTTCAACCGCGACGTGCTGGACTGCGTG
GTGGACGAGATGGACTTCTCCAGCATGGAGCTGGACGAGGCCCTGCGCAAGTTCCAGGCA
CACATCCGTGTGCAGGGGGAGGCTCAGAAGGTGGAGCGGCTCATTGAGGCCTTCAGCCAG
CGCTACTGCATGTGCAACCCCGAAGTGGTTCAGCAGTTCCACAACCCCGACACCATCTTC
ATCCTCGCCTTCGCCATCATCCTCCTCAACACCGACATGTACAGCCCCAACATCAAGCCT
GACCGGAAGATGATGCTGGAGGACTTCATCCGAAACCTTCGAGGTGTGGACGATGGCGCT
GACATCCCCAGGGAGCTGGTGGTAGGCATCTATGAGAGGATACAGCAGAAGGAGCTCAAG
TCCAATGAGGACCACGTCACGTACGTCACCAAGGTGGAGAAGTCCATTGTGGGCATGAAG
ACAGTGCTGTCCGTGCCCCACCGCCGCCTGGTGTGCTGCAGCCGGCTCTTCGAGGTGACG
GATGTGAACAAGCTGCAGAAGCAGGCAGCGCATCAGAGGGAGGTGTTCCTCTTCAATGAC
CTGCTGGTGATTCTCAAACTTTGCCCGAAGAAGAAGAGCTCCTCCACGTACACCTTTTGC
AAGTCAGTTGGCCTGCTGGGCATGCAGTTCCAGCTCTTTGAGAACGAGTATTACTCTCAT
GGCATCACACTGGTGACCCCGCTCTCGGGCTCCGAGAAGAAGCAGGTGCTGCATTTCTGT
GCCCTGGGCTCGGACGAGATGCAGAAGTTCGTGGAGGACCTGAAGGAGTCCATTGCTGAG
GTGACGGAGCTGGAGCAGATCCGAATAGAGTGGGAGCTGGAGAAGCAGCAGGGAACAAAG
ACACTCTCCTTCAAGCCCTGCGGAGCCCAGGGGGACCCACAGTCAAAGCAAGGATCGCCG
ACAGCCAAAAGGGAAGCCGCGCTCAGGGAGAGGCCGGCGGAGAGCACGGTGGAGGTGTCA
ATTCACAACAGGCTTCAAACGTCCCAGCACAACTCCGGGCTGGGGGCCGAGAGGGGAGCG
CCGGTGCCGCCGCCAGACCTGCAGCCTAGCCCCCCGAGACAGCAGACCCCACCACTGCCG
CCGCCGCCACCCACGCCCCCGGGCACCCTGGTGCAGTGCCAGCAAATTGTCAAGGTCATT
GTCCTGGACAAGCCCTGCCTGGCCCGCATGGAGCCCCTGCTGAGCCAGGCTCTCTCCTGC
TACACCTCGTCGTCCTCTGACTCCTGCGGCTCCACACCCCTGGGCGGTCCCGGCTCTCCG
GTCAAGGTCACCCACCAGCCTCCGCTGCCCCCGCCCCCACCCCCCTACAACCACCCTCAC
CAGTTCTGTCCCCCAGGCTCCCTGCTGCACGGGCACCGCTACTCCAGTGGCTCAAGGAGC
CTGGTGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1182 |
| Molecular Weight
| 127619.9 |
| Theoretical pI
| 6.49 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>IQ motif and SEC7 domain-containing protein 3
MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRERIDELERRLDELSAENRSLWEHQQLL
QAQPPPGLVPPSSAPLPAAPATAPAAAARAQEPLQDQGQRSAAAPHPAPDRPPRQHHGQL
LEQPQRGPGSRAHTPQSPHKHLGTQGAVTDKEKERPPSCCAAAGALLQHKSPSALGKGVL
SRRPENETVLHQFCCPAADACSDLASQSDGSCTQAGGGMEDSVVAAAAVAAGRPSAHAPK
AQAQELQEEEERPGAGAASPRAGPQHKASPGRQQPALATALCPHAPAASDYELSLDLKNK
QIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRSPT
AESLAAEKALMEGYGLVGLPLVRSPSLPPTFAGTLTELEDSFTEQVQSLAKSIDDALSTW
SLKTMCSLRESGAYQLHQALQAAAGPPGLEAEGRAPESAGPGPGDDAAETPGLPPAHSGT
LMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGETSGREAPEA
PAVGREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSS
STSTKSAKSGSEASASASKDALQAMILSLPRYHCENPASCKSPTLSTDTLRKRLYRIGLN
LFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCV
VDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIF
ILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELK
SNEDHVTYVTKVEKSIVGMKTVLSVPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFND
LLVILKLCPKKKSSSTYTFCKSVGLLGMQFQLFENEYYSHGITLVTPLSGSEKKQVLHFC
ALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQGTKTLSFKPCGAQGDPQSKQGSP
TAKREAALRERPAESTVEVSIHNRLQTSQHNSGLGAERGAPVPPPDLQPSPPRQQTPPLP
PPPPTPPGTLVQCQQIVKVIVLDKPCLARMEPLLSQALSCYTSSSSDSCGSTPLGGPGSP
VKVTHQPPLPPPPPPYNHPHQFCPPGSLLHGHRYSSGSRSLV
|
| External Links |
|---|
| GenBank ID Protein
| 282721018 |
| UniProtKB/Swiss-Prot ID
| Q9UPP2 |
| UniProtKB/Swiss-Prot Entry Name
| IQEC3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001170738.1 |
| GeneCard ID
| IQSEC3 |
| GenAtlas ID
| IQSEC3 |
| HGNC ID
| HGNC:29193 |
| References |
|---|
| General References
| Not Available |