| Identification |
|---|
| HMDB Protein ID
| CDBP05087 |
| Secondary Accession Numbers
| Not Available |
| Name
| Alpha-catulin |
| Description
| Not Available |
| Synonyms
|
- ACRP
- Alpha-catenin-related protein
- Catenin alpha-like protein 1
|
| Gene Name
| CTNNAL1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in structural molecule activity |
| Specific Function
| May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1) |
| GO Classification
|
| Component |
| organelle |
| non-membrane-bounded organelle |
| intracellular non-membrane-bounded organelle |
| actin cytoskeleton |
| cytoskeleton |
| Function |
| binding |
| structural molecule activity |
| protein binding |
| cell adhesion molecule binding |
| cadherin binding |
| Process |
| cell adhesion |
| cellular process |
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
- Peripheral membrane protein
- cytoskeleton
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9q31.2 |
| SNPs
| CTNNAL1 |
| Gene Sequence
|
>2205 bp
ATGGCCGCCTCTCCCGGACCCGCCGGCGTTGGCGGCGCCGGAGCAGTCTACGGCTCCGGC
TCTTCGGGCTTCGCCCTCGACTCGGGACTGGAGATCAAAACTCGCTCGGTGGAGCAGACG
CTACTCCCGCTGGTTTCTCAGATCACCACGCTTATTAATCATAAAGATAATACCAAAAAG
TCCGATAAAACTCTGCAAGCAATTCAGCGTGTAGGACAAGCTGTCAACTTGGCAGTTGGA
AGATTTGTTAAAGTAGGAGAAGCTATAGCCAATGAAAACTGGGATTTGAAAGAAGAAATA
AATATTGCTTGTATTGAAGCTAAACAAGCAGGAGAAACAATTGCAGCACTTACAGACATA
ACCAACTTGAACCATCTGGAATCTGATGGGCAGATCACAATTTTTACAGACAAAACAGGA
GTGATAAAGGCTGCAAGATTACTTCTTTCTTCAGTGACAAAAGTGTTGTTGCTGGCAGAC
CGAGTAGTCATTAAACAGATAATAACATCAAGAAATAAGGTTCTCGCAACTATGGAAAGA
CTAGAGAAAGTGAATAGCTTTCAAGAGTTTGTCCAAATATTCAGTCAATTTGGAAATGAA
ATGGTGGAGTTTGCACATCTGAGTGGAGATAGACAAAATGATTTGAAAGATGAAAAGAAA
AAGGCAAAAATGGCAGCAGCTAGGGCAGTTCTTGAAAAGTGTACAATGATGCTTCTCACT
GCTTCAAAGACATGTCTGAGGCATCCTAACTGCGAATCAGCCCATAAAAACAAAGAAGGA
GTATTTGACCGTATGAAAGTGGCATTGGATAAGGTCATTGAAATTGTGACTGACTGTAAA
CCGAATGGAGAGACTGACATTTCATCTATCAGTATTTTTACTGGAATTAAGGAATTCAAG
ATGAATATTGAAGCTCTTCGGGAGAATCTTTATTTTCAGTCCAAAGAGAACCTTTCTGTG
ACATTGGAAGTCATCTTGGAGCGTATGGAGGACTTTACTGATTCTGCCTACACCAGCCAT
GAGCACAGAGAACGCATCTTGGAACTGTCAACTCAGGCGAGAATGGAACTGCAGCAGTTA
ATTTCTGTGTGGATTCAAGCTCAAAGCAAGAAAACAAAAAGCATCGCTGAAGAACTGGAA
CTCAGTATTTTGAAAATCAGTCACAGTCTTAATGAACTTAAGAAAGAACTTCATAGTACA
GCGACACAGCTGGCAGCAGATCTATTAAAATACCATGCTGATCATGTGGTTCTAAAAGCA
TTAAAACTTACTGGAGTAGAAGGAAATTTAGAAGCTTTGGCTGAATATGCCTGTAAACTC
TCTGAACAGAAAGAGCAGCTTGTTGAGACCTGTCGATTGTTACGACACATATCTGGGACA
GAACCTCTGGAAATAACCTGTATACATGCAGAGGAGACATTTCAGGTGACTGGCCAACAG
ATAATTTCTGCTGCTGAAACATTGACATTGCATCCATCTAGTAAAATTGCTAAAGAAAAC
CTAGATGTATTTTGTGAAGCTTGGGAATCCCAAATTAGTGACATGTCAACACTGCTGAGA
GAAATCAATGACGTGTTTGAAGGGAGACGAGGAGAGAAGTATGGCTACCTTTCACTTCCA
AAGCCAATGAAGAATAATGCAAACCTGAAATCATTAAAGCCAGACAAGCCTGACTCTGAG
GAGCAAGCCAAGATAGCAAAGCTTGGACTTAAGCTGGGTTTGCTCACCTCTGACGCTGAC
TGCGAAATTGAGAAGTGGGAAGATCAGGAGAATGAGATTGTTCAATATGGACGGAACATG
TCCAGTATGGCCTATTCTCTGTATTTATTCACTAGAGGAGAGGGGCCACTGAAAACTTCC
CAGGATTTAATTCATCAACTAGAGGTTTTTGCTGCAGAGGGTTTAAAGCTTACTTCCAGT
GTTCAAGCTTTTTCAAAACAGCTGAAAGACGATGACAAGCTTATGCTTCTCCTGGAAATA
AACAAGCTAATTCCTCTATGCCACCAGCTCCAGACAGTAACTAAGACTTCTTTGCAGAAT
AAAGTATTTCTAAAGGTTGACAAGTGTATTACGAAGACAAGATCCATGATGGCTCTCTTA
GTCCAACTTCTTTCACTTTGTTATAAACTGCTGAAGAAGCTTCAGATGGAAAATAACGGA
TGGGTCTCAGTTACAAATAAGGACACTATGGATAGTAAAACTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 734 |
| Molecular Weight
| 81895.6 |
| Theoretical pI
| 6.62 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Alpha-catulin
MAASPGPAGVGGAGAVYGSGSSGFALDSGLEIKTRSVEQTLLPLVSQITTLINHKDNTKK
SDKTLQAIQRVGQAVNLAVGRFVKVGEAIANENWDLKEEINIACIEAKQAGETIAALTDI
TNLNHLESDGQITIFTDKTGVIKAARLLLSSVTKVLLLADRVVIKQIITSRNKVLATMER
LEKVNSFQEFVQIFSQFGNEMVEFAHLSGDRQNDLKDEKKKAKMAAARAVLEKCTMMLLT
ASKTCLRHPNCESAHKNKEGVFDRMKVALDKVIEIVTDCKPNGETDISSISIFTGIKEFK
MNIEALRENLYFQSKENLSVTLEVILERMEDFTDSAYTSHEHRERILELSTQARMELQQL
ISVWIQAQSKKTKSIAEELELSILKISHSLNELKKELHSTATQLAADLLKYHADHVVLKA
LKLTGVEGNLEALAEYACKLSEQKEQLVETCRLLRHISGTEPLEITCIHAEETFQVTGQQ
IISAAETLTLHPSSKIAKENLDVFCEAWESQISDMSTLLREINDVFEGRRGEKYGYLSLP
KPMKNNANLKSLKPDKPDSEEQAKIAKLGLKLGLLTSDADCEIEKWEDQENEIVQYGRNM
SSMAYSLYLFTRGEGPLKTSQDLIHQLEVFAAEGLKLTSSVQAFSKQLKDDDKLMLLLEI
NKLIPLCHQLQTVTKTSLQNKVFLKVDKCITKTRSMMALLVQLLSLCYKLLKKLQMENNG
WVSVTNKDTMDSKT
|
| External Links |
|---|
| GenBank ID Protein
| 197692267 |
| UniProtKB/Swiss-Prot ID
| Q9UBT7 |
| UniProtKB/Swiss-Prot Entry Name
| CTNL1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB451283 |
| GeneCard ID
| CTNNAL1 |
| GenAtlas ID
| CTNNAL1 |
| HGNC ID
| HGNC:2512 |
| References |
|---|
| General References
| Not Available |