| Identification |
|---|
| HMDB Protein ID
| CDBP05077 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein SOLO |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| SOLO |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in Rho guanyl-nucleotide exchange factor activity |
| Specific Function
| May act as a guanine nucleotide exchange factor (GEF) |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| enzyme regulator activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| small gtpase regulator activity |
| ras guanyl-nucleotide exchange factor activity |
| rho guanyl-nucleotide exchange factor activity |
| Process |
| regulation of ras protein signal transduction |
| regulation of rho protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| SOLO |
| Gene Sequence
|
>4560 bp
ATGGAGCCTGAGCCAGTGGAGGACTGTGTGCAGAGCACTCTCGCCGCCCTGTATCCACCC
TTTGAGGCAACAGCCCCCACCCTGTTGGGCCAGGTGTTCCAGGTGGTGGAGAGGACTTAT
CGGGAGGACGCACTGAGGTACACGCTGGACTTCCTGGTACCAGCCAAGCACCTGCTTGCC
AAGGTCCAGCAGGAAGCCTGTGCCCAATACAGTGGATTCCTCTTCTTCCATGAGGGGTGG
CCGCTCTGCCTGCATGAACAGGTGGTGGTGCAGCTAGCAGCCCTACCCTGGCAACTGCTG
CGCCCAGGAGACTTCTATCTGCAGGTGGTGCCCTCAGCTGCCCAAGCACCCCGACTAGCA
CTCAAGTGTCTGGCCCCTGGGGGTGGGCGGGTGCAGGAGGTTCCTGTGCCCAATGAGGCT
TGTGCCTACCTATTCACACCTGAGTGGCTACAAGGCATCAACAAGGACCGGCCAACAGGT
CGCCTCAGTACCTGCCTACTGTCTGCGCCCTCTGGGATTCAGCGGCTGCCCTGGGCTGAG
CTCATCTGTCCACGATTTGTGCACAAAGAGGGCCTCATGGTTGGACATCAGCCAAGTACA
CTGCCCCCAGAACTGCCCTCTGGACCTCCAGGGCTTCCCAGCCCTCCACTTCCTGAGGAG
GCGCTGGGTACCCGGAGTCCTGGGGATGGGCACAATGCCCCTGTGGAAGGACCTGAGGGC
GAGTATGTGGAGCTGTTAGAGGTGACGCTGCCCGTGAGGGGGAGCCCAACAGATGCTGAA
GGCTCCCCAGGCCTCTCCAGAGTCCGGACGGTACCCACCCGCAAGGGCGCTGGAGGGAAG
GGCCGCCACCGGAGACACCGGGCGTGGATGCACCAGAAGGGCCTGGGGCCTCGGGGCCAG
GATGGAGCACGCCCACCCGGCGAGGGGAGCAGCACCGGAGCCTCCCCTGAGTCTCCCCCA
GGAGCTGAGGCTGTCCCAGAGGCAGCAGTCTTGGAGGTGTCTGAGCCCCCAGCAGAGGCT
GTGGGAGAAGCCTCCGGATCTTGCCCCCTGAGGCCAGGGGAGCTTAGAGGAGGAGGAGGA
GGAGGCCAGGGGGCTGAAGGACCACCTGGTACCCCTCGGAGAACAGGCAAAGGAAACAGA
AGAAAGAAGCGAGCTGCAGGTCGAGGGGCTCTTAGCCGAGGAGGGGACAGTGCCCCACTG
AGCCCTGGGGACAAGGAAGATGCCAGCCACCAAGAAGCCCTTGGCAATCTGCCCTCACCA
AGTGAGCACAAGCTTCCAGAATGCCACCTGGTTAAGGAGGAATATGAAGGCTCAGGGAAG
CCAGAATCTGAGCCAAAAGAGCTCAAAACAGCAGGCGAGAAAGAGCCTCAGCTCTCTGAA
GCCTGTGGGCCTACAGAAGAGGGGGCCGGAGAGAGAGAGCTGGAGGGGCCAGGCCTGCTG
TGTATGGCAGGACACACAGGCCCAGAAGGCCCCCTGTCTGACACTCCAACACCTCCGCTG
GAGACTGTGCAGGAAGGAAAAGGGGACAACATTCCAGAAGAGGCCCTTGCAGTCTCCGTC
TCTGATCACCCTGATGTAGCTTGGGACTTGATGGCATCTGGATTCCTCATCCTGACGGGA
GGGGTGGACCAGAGTGGGCGAGCTCTGCTGACCATTACCCCACCGTGCCCTCCTGAGGAG
CCCCCACCCTCCCGAGACACGCTGAACACAACTCTTCATTACCTCCACTCACTGCTCAGG
CCTGATCTACAGACACTGGGGCTGTCCGTCCTGCTGGACCTTCGTCAGGCACCTCCACTG
CCTCCAGCACTCATTCCTGCCTTGAGCCAACTTCAGGACTCAGGAGATCCTCCCCTTGTT
CAGCGGCTGCTGATTCTCATTCATGATGACCTTCCAACTGAACTCTGTGGATTTCAGGGT
GCTGAGGTGCTGTCAGAGAATGATCTGAAAAGAGTGGCCAAGCCAGAGGAGCTGCAGTGG
GAGTTAGGAGGTCACAGGGACCCCTCTCCCAGTCACTGGGTAGAGATACACCAGGAAGTG
GTAAGGCTATGTCGCCTGTGCCAAGGTGTGCTGGGCTCGGTACGGCAGGCCATTGAGGAG
CTGGAGGGAGCAGCAGAGCCAGAGGAAGAGGAGGCAGTGGGAATGCCCAAGCCACTGCAG
AAGGTGCTGGCAGATCCCCGGCTGACGGCACTGCAGAGGGATGGGGGGGCCATCCTGATG
AGGCTGCGCTCCACTCCCAGCAGCAAGCTGGAGGGCCAAGGCCCAGCTACACTGTATCAG
GAAGTGGACGAGGCCATTCACCAGCTTGTGCGCCTCTCCAACCTGCACGTGCAGCAGCAA
GAGCAGCGGCAGTGCCTGCGGCGACTCCAGCAGGTGTTGCAGTGGCTCTCGGGCCCAGGG
GAGGAGCAGCTGGCAAGCTTTGCTATGCCTGGGGACACCTTGTCTGCCCTGCAGGAGACA
GAGCTGCGATTCCGTGCTTTCAGCGCTGAGGTCCAGGAGCGCCTGGCCCAGGCACGGGAG
GCCCTGGCTCTGGAGGAGAATGCCACCTCCCAGAAGGTGCTGGATATCTTTGAACAGCGG
CTGGAGCAGGTTGAGAGTGGCCTCCATCGGGCCCTGCGGCTACAGCGCTTCTTCCAGCAG
GCACATGAATGGGTGGATGAGGGCTTTGCTCGGCTGGCAGGAGCTGGGCCGGGTCGGGAG
GCTGTGCTGGCTGCACTGGCCCTGCGGCGGGCCCCAGAGCCCAGTGCCGGCACCTTCCAG
GAGATGCGGGCCCTGGCCCTGGACCTGGGCAGCCCAGCAGCCCTGCGAGAATGGGGCCGC
TGCCAGGCCCGCTGCCAAGAGCTAGAGAGGAGGATCCAGCAACACGTGGGAGAGGAGGCG
AGCCCACGGGGCTACCGACGACGGCGGGCAGACGGTGCCAGCAGTGGAGGGGCCCAGTGG
GGGCCCCGCAGCCCCTCGCCCAGCCTCAGCTCCTTGCTGCTCCCCAGCAGCCCTGGGCCA
CGGCCAGCCCCATCCCATTGCTCCCTGGCCCCATGTGGAGAGGACTATGAGGAAGAGGGC
CCTGAGCTGGCTCCAGAAGCAGAGGGCAGGCCCCCAAGAGCTGTGCTGATCCGAGGCCTG
GAGGTCACCAGCACTGAGGTGGTAGACAGGACGTGCTCACCACGGGAACACGTGCTGCTG
GGCCGGGCTAGGGGGCCAGACGGACCCTGGGGAGTAGGCACCCCCCGGATGGAGCGCAAG
CGAAGCATCAGTGCCCAGCAGCGGCTGGTGTCTGAGCTGATTGCCTGTGAACAAGATTAC
GTGGCCACCTTGAGTGAGCCAGTGCCACCCCCTGGGCCTGAGCTGACGCCTGAACTTCGG
GGCACCTGGGCTGCTGCCCTGAGTGCCCGGGAAAGGCTTCGCAGCTTCCACCGGACACAC
TTTCTGCGGGAGCTTCAGGGCTGCGCCACCCACCCCCTACGCATTGGGGCCTGCTTCCTT
CGCCACGGGGACCAGTTCAGCCTTTATGCACAGTACGTGAAGCACCGACACAAACTGGAG
AATGGTCTGGCTGCGCTCAGTCCCTTAAGCAAGGGCTCCATGGAGGCTGGCCCTTACCTG
CCCCGAGCCCTGCAGCAGCCTCTGGAACAGCTGACTCGGTATGGGCGGCTCCTGGAGGAG
CTCCTGAGGGAAGCTGGGCCTGAGCTCAGTTCTGAGTGCCGGGCCCTTGGGGCTGCTGTA
CAGCTGCTCCGGGAACAAGAGGCCCGTGGCAGAGACCTGCTGGCCGTGGAGGCGGTGCGT
GGCTGTGAGATAGATCTGAAGGAGCAGGGACAGCTCTTGCATCGAGACCCCTTCACTGTC
ATCTGTGGCCGAAAGAAGTGCCTTCGCCATGTCTTTCTCTTCGAGCATCTCCTCCTGTTC
AGCAAGCTCAAGGGCCCTGAAGGGGGGTCAGAGATGTTTGTTTACAAGCAGGCCTTTAAG
ACTGCTGATATGGGGCTGACAGAAAACATCGGGGACAGCGGACTCTGCTTTGAGTTGTGG
TTTCGGCGGCGGCGTGCACGAGAGGCATACACTCTGCAGGCAACCTCACCAGAGATCAAA
CTCAAGTGGACAAGTTCTATTGCCCAGCTGCTGTGGAGACAGGCAGCCCACAACAAGGAG
CTCCGAGTGCAGCAGATGGTGTCCATGGGCATTGGGAATAAACCCTTCCTGGACATCAAA
GCCCTTGGGGAGCGGACGCTGAGTGCCCTGCTCACTGGAAGAGCCGCCCGCACCCGGGCC
TCCGTGGCCGTGTCATCCTTTGAGCATGCCGGCCCCTCCCTTCCCGGCCTTTCGCCGGGA
GCCTGCTCCCTGCCTGCCCGCGTCGAGGAGGAGGCCTGGGATCTGGACGTCAAGCAAATT
TCCCTGGCCCCAGAAACACTTGACTCTTCTGGAGATGTGTCCCCAGGACCAAGAAACAGC
CCCAGCCTGCAACCCCCCCACCCTGGGAGCAGCACTCCCACCCTGGCCAGTCGAGGGATC
TTAGGGCTATCCCGACAGAGTCATGCTCGAGCCCTGAGTGACCCCACCACGCCTCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1519 |
| Molecular Weight
| 164656.0 |
| Theoretical pI
| 6.07 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protein SOLO
MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLA
KVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLA
LKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAE
LICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEG
EYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQ
DGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG
GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP
SEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLL
CMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTG
GVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPL
PPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQW
ELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQ
KVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQ
EQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQARE
ALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGRE
AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEA
SPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEG
PELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERK
RSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSARERLRSFHRTH
FLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYL
PRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVR
GCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFK
TADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKE
LRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPG
ACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGI
LGLSRQSHARALSDPTTPL
|
| External Links |
|---|
| GenBank ID Protein
| 50843837 |
| UniProtKB/Swiss-Prot ID
| Q8TER5 |
| UniProtKB/Swiss-Prot Entry Name
| SOLO_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_018071.3 |
| GeneCard ID
| SOLO |
| GenAtlas ID
| ARHGEF40 |
| HGNC ID
| HGNC:25516 |
| References |
|---|
| General References
| Not Available |