Cannabis Compound Database: Showing Protein Growth factor receptor-bound protein 2 (CDBP05073)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP05073

Secondary Accession Numbers

Not Available

Name

Growth factor receptor-bound protein 2

Description

Not Available

Synonyms

Adapter protein GRB2
Protein Ash
SH2/SH3 adapter GRB2

Gene Name

GRB2

Protein Type

Receptor

Biological Properties

General Function

Involved in protein binding

Specific Function

Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death

GO Classification

Function
binding
protein binding

Cellular Location

Golgi apparatus

Pathways

Name	SMPDB/Pathwhiz	KEGG
Fc Epsilon Receptor I Signaling in Mast Cells		Not Available
Insulin Signalling		Not Available
BCR-ABL Action in CML Pathogenesis		Not Available
Imatinib Inhibition of BCR-ABL		Not Available
Dasatinib Inhibition of BCR-ABL		Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

17q24-q25

SNPs

GRB2

Gene Sequence

>654 bp
ATGGAAGCCATCGCCAAATATGACTTCAAAGCTACTGCAGACGACGAGCTGAGCTTCAAA
AGGGGGGACATCCTCAAGGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAG
CTTAATGGAAAAGACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCGTGG
TTTTTTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGCTTAGCAAACAGCGGCACGAT
GGGGCCTTTCTTATCCGAGAGAGTGAGAGCGCTCCTGGGGACTTCTCCCTCTCTGTCAAG
TTTGGAAACGATGTGCAGCACTTCAAGGTGCTCCGAGATGGAGCCGGGAAGTACTTCCTC
TGGGTGGTGAAGTTCAATTCTTTGAATGAGCTGGTGGATTATCACAGATCTACATCTGTC
TCCAGAAACCAGCAGATATTCCTGCGGGACATAGAACAGGTGCCACAGCAGCCGACATAC
GTCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGGCTTCCGCCGGGGA
GATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGTGGAAAGGAGCTTGCCACGGG
CAGACCGGCATGTTTCCCCGCAATTATGTCACCCCCGTGAACCGGAACGTCTAA

Protein Properties

Number of Residues

217

Molecular Weight

25206.2

Theoretical pI

6.25

Pfam Domain Function

SH2 (PF00017 )
SH3_1 (PF00018 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Growth factor receptor-bound protein 2
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

P62993

UniProtKB/Swiss-Prot Entry Name

GRB2_HUMAN

PDB IDs