Showing Protein Ras-specific guanine nucleotide-releasing factor RalGPS2 (CDBP05062)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 compounds
Identification
HMDB Protein ID CDBP05062
Secondary Accession Numbers Not Available
Name Ras-specific guanine nucleotide-releasing factor RalGPS2
Description Not Available
Synonyms
  1. Ral GEF with PH domain and SH3-binding motif 2
  2. RalA exchange factor RalGPS2
Gene Name RALGPS2
Protein Type Enzyme
Biological Properties
General Function Involved in guanyl-nucleotide exchange factor activity
Specific Function Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion
GO Classification
Component
cell part
intracellular
Function
enzyme regulator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
guanyl-nucleotide exchange factor activity
Process
signal transduction
intracellular signal transduction
small gtpase mediated signal transduction
biological regulation
regulation of biological process
regulation of cellular process
Cellular Location
  1. Cell membrane
  2. Cytoplasm
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 1q25.2
SNPs RALGPS2
Gene Sequence 
>1752 bp
ATGGACCTAATGAACGGGCAGGCAAGCAGTGTCAATATTGCAGCTACTGCTTCTGAGAAA
AGTAGCAGCTCTGAATCCTTAAGTGACAAAGGCTCTGAATTGAAGAAAAGCTTTGATGCT
GTGGTATTCGATGTTCTTAAGGTTACACCAGAAGAATATGCGGGTCAGATAACATTAATG
GATGTTCCAGTATTTAAAGCTATTCAACCAGATGAGCTTTCAAGTTGTGGATGGAATAAA
AAAGAAAAATATAGTTCTGCACCAAATGCAGTTGCCTTCACAAGAAGATTCAATCATGTA
AGCTTTTGGGTTGTTAGAGAGATTCTTCATGCTCAAACATTAAAAATTAGAGCAGAAGTT
TTGAGCCACTATATTAAAACTGCTAAGAAACTGTATGAGCTGAATAACCTTCATGCACTT
ATGGCAGTGGTTTCTGGCCTACAGAGTGCCCCAATTTTCAGGTTGACTAAAACATGGGCG
TTATTAAGTCGAAAAGACAAAACTACCTTTGAAAAATTAGAATATGTAATGAGTAAAGAA
GATAACTACAAAAGACTCAGAGACTATATAAGTAGCTTAAAGATGACACCTTGCATTCCC
TATTTAGGTATCTATTTGTCAGATTTAACATACATCGATTCAGCATACCCATCAACTGGC
AGCATTCTAGAAAATGAGCAAAGATCAAATTTAATGAATAATATCCTTCGAATAATTTCT
GATTTACAGCAGTCTTGTGAATATGATATTCCCATGTTGCCTCATGTCCAAAAATATCTC
AACTCTGTTCAGTATATAGAAGAACTACAAAAATTTGTGGAAGACGATAATTACAAGCTT
TCATTAAAGATAGAACCAGGGACAAGCACCCCACGTTCTGCTGCTTCCAGAGAAGATTTA
GTAGGTCCTGAAGTAGGAGCGTCTCCACAGAGTGGACGAAAAAGTGTGGCAGCTGAAGGA
GCCTTGCTCCCACAGACACCGCCATCCCCTCGGAATCTGATTCCACATGGACATAGGAAG
TGCCATAGTTTGGGTTATAATTTCATTCATAAAATGAACACAGCAGAATTTAAGAGTGCA
ACGTTTCCAAATGCAGGACCAAGACATCTGTTAGATGATAGCGTCATGGAGCCCCATGCG
CCATCTCGAGGCCAAGCTGAAAGTTCTACTCTTTCTAGTGGAATATCAATAGGTAGCAGC
GATGGTTCTGAACTAAGTGAAGAGACCTCATGGCCTGCTTTTGAAAGGAACAGATTATAC
CATTCTCTCGGCCCGGTGACAAGAGTGGCACGAAATGGCTATCGAAGTCACATGAAGGCC
AGCAGTTCTGCAGAATCAGAAGATTTGGCAGTACATTTATATCCAGGAGCTGTTACTATT
CAAGGTGTTCTCAGGAGAAAAACTTTGTTAAAAGAAGGCAAAAAGCCTACAGTAGCATCT
TGGACAAAATATTGGGCAGCTTTGTGTGGGACACAGCTTTTTTACTATGCTGCCAAATCT
CTAAAGGCTACCGAAAGAAAACATTTCAAATCAACATCCAATAAGAACGTATCTGTGATA
GGATGGATGGTGATGATGGCTGATGACCCTGAACATCCTGATCTCTTCCTGCTGACTGAC
TCTGAGAAAGGAAATTCGTACAAGTTTCAAGCTGGCAATAGAATGAATGCAATGTTATGG
TTTAAGCATTTGAGTGCAGCCTGCCAAAGTAACAAACAACAGGTTCCTACAAACTTGATG
ACTTTTGAGTAG
Protein Properties
Number of Residues 583
Molecular Weight 65166.5
Theoretical pI 9.05
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Ras-specific guanine nucleotide-releasing factor RalGPS2
MDLMNGQASSVNIAATASEKSSSSESLSDKGSELKKSFDAVVFDVLKVTPEEYAGQITLM
DVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHAQTLKIRAEV
LSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFEKLEYVMSKE
DNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENEQRSNLMNNILRIIS
DLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEPGTSTPRSAASREDL
VGPEVGASPQSGRKSVAAEGALLPQTPPSPRNLIPHGHRKCHSLGYNFIHKMNTAEFKSA
TFPNAGPRHLLDDSVMEPHAPSRGQAESSTLSSGISIGSSDGSELSEETSWPAFERNRLY
HSLGPVTRVARNGYRSHMKASSSAESEDLAVHLYPGAVTIQGVLRRKTLLKEGKKPTVAS
WTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNKNVSVIGWMVMMADDPEHPDLFLLTD
SEKGNSYKFQAGNRMNAMLWFKHLSAACQSNKQQVPTNLMTFE
GenBank ID Protein 32441283
UniProtKB/Swiss-Prot ID Q86X27
UniProtKB/Swiss-Prot Entry Name RGPS2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_152663.3
GeneCard ID RALGPS2
GenAtlas ID RALGPS2
HGNC ID HGNC:30279
References
General References Not Available