| Identification |
|---|
| HMDB Protein ID
| CDBP05058 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ras-GEF domain-containing family member 1B |
| Description
| Not Available |
| Synonyms
|
- GPI gamma-4
|
| Gene Name
| RASGEF1B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in guanyl-nucleotide exchange factor activity |
| Specific Function
| Guanine nucleotide exchange factor (GEF) for Ras family proteins (in vitro) |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| enzyme regulator activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| guanyl-nucleotide exchange factor activity |
| Process |
| signal transduction |
| intracellular signal transduction |
| small gtpase mediated signal transduction |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4q21.21 |
| SNPs
| RASGEF1B |
| Gene Sequence
|
>1422 bp
ATGCCTCAGACTCCTCCCTTTTCAGCAATGTTTGACAGCAGTGGTTACAATCGAAACCTC
TATCAGTCTGCAGAGGACAGCTGTGGAGGGTTGTATTACCATGACAACAACCTCCTCTCT
GGATCCCTGGAAGCACTCATCCAGCACTTAGTACCTAATGTGGATTACTATCCAGATAGA
ACATACATATTTACCTTCCTACTCAGTTCTCGGTTATTTATGCATCCGTATGAGCTAATG
GCCAAAGTTTGCCACTTATGTGTTGAGCACCAGAGACTAAGTGATCCTGATAGTGATAAG
AACCAGATGAGAAAAATTGCACCCAAAATCCTTCAACTCCTCACGGAATGGACGGAAACA
TTTCCCTATGATTTTCGGGATGAAAGAATGATGAGAAACTTAAAAGATCTGGCTCACCGA
ATAGCCAGTGGCGAAGAGCAGACATACAGAAAGAATGTCCAGCAAATGATGCAGTGTCTG
ATCCGCAAGCTTGCTGCGCTCAGCCAGTACGAAGAAGTCCTGGCAAAAATCAGCTCCACA
TCCACAGATCGGCTCACAGTTCTCAAGACCAAGCCACAGTCTATACAAAGGGATATCATT
ACTGTCTGCAACGACCCTTACACGTTGGCCCAGCAGCTGACTCATATAGAGCTGGAGAGG
CTCAATTATATTGGGCCAGAAGAATTTGTTCAGGCGTTCGTGCAGAAGGACCCTTTGGAT
AATGACAAGAGTTGCTACAGTGAACGGAAGAAAACACGAAACTTAGAAGCTTACGTGGAA
TGGTTTAATCGCCTCAGCTACTTGGTTGCTACAGAAATCTGTATGCCTGTTAAGAAAAAA
CACCGAGCAAGAATGATTGAGTATTTCATTGACGTAGCTCGGGAGTGTTTTAACATTGGC
AACTTCAACTCCTTGATGGCGATAATCTCTGGTATGAATATGAGCCCAGTCTCTCGACTA
AAAAAAACTTGGGCCAAAGTGAAGACTGCAAAATTTGACATTCTTGAGCATCAGATGGAC
CCTTCAAGCAATTTCTATAATTATCGAACAGCTCTTCGTGGGGCAGCACAAAGGTCTTTA
ACTGCTCATAGTAGTAGAGAAAAGATTGTGATACCATTCTTCAGTCTCTTAATCAAAGAT
ATTTATTTCCTCAATGAGGGTTGTGCCAACCGCCTTCCCAATGGCCATGTCAATTTTGAG
AAATTTTGGGAACTGGCCAAACAAGTGAGTGAATTTATGACATGGAAACAAGTGGAGTGT
CCATTTGAGAGGGACCGGAAGATCTTGCAGTATCTGCTCACAGTACCAGTCTTCAGTGAA
GATGCTCTCTACTTGGCTTCTTATGAGAGTGAAGGACCTGAAAATCATATAGAGAAAGAC
AGATGGAAGTCTTTAAGGTCGAGCCTCTTAGGCAGAGTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 473 |
| Molecular Weight
| 55359.0 |
| Theoretical pI
| 8.09 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ras-GEF domain-containing family member 1B
MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR
TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET
FPYDFRDERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISST
STDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLD
NDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIG
NFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSL
TAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC
PFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV
|
| External Links |
|---|
| GenBank ID Protein
| 22749129 |
| UniProtKB/Swiss-Prot ID
| Q0VAM2 |
| UniProtKB/Swiss-Prot Entry Name
| RGF1B_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_152545.1 |
| GeneCard ID
| RASGEF1B |
| GenAtlas ID
| RASGEF1B |
| HGNC ID
| HGNC:24881 |
| References |
|---|
| General References
| Not Available |