| Identification |
|---|
| HMDB Protein ID
| CDBP05055 |
| Secondary Accession Numbers
| Not Available |
| Name
| PH and SEC7 domain-containing protein 3 |
| Description
| Not Available |
| Synonyms
|
- Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6
- Hepatocellular carcinoma-associated antigen 67
- Pleckstrin homology and SEC7 domain-containing protein 3
|
| Gene Name
| PSD3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ARF guanyl-nucleotide exchange factor activity |
| Specific Function
| Guanine nucleotide exchange factor for ARF6 |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| gtpase regulator activity |
| small gtpase regulator activity |
| enzyme regulator activity |
| arf guanyl-nucleotide exchange factor activity |
| nucleoside-triphosphatase regulator activity |
| Process |
| regulation of ras protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of arf protein signal transduction |
| regulation of cellular process |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
- Cell junction
- synapse
- postsynaptic cell membrane
- postsynaptic density
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8p21.3 |
| SNPs
| PSD3 |
| Gene Sequence
|
>3144 bp
ATGGAAGGAAGGAGCGCAGCGGCAGAGACATTTGTTTGGGTGAACAATGCATCTGCACAT
TCCCAGAGTGTTGCCAAGGCCAAATATGAATTTTTATTTGGCAGATCTGAAGGGAAAGCT
CCAGATACTAGTGATCATGGAGGAAGCACTTTACTCCCACCAAATGTCACAAATGAATTT
CCAGAATATGGGACCATGGAGGAAGGTGGAGAAGGCCTAAGGGCTTCTCTGGAATTTGAT
GGTGAGGCTCTGCCATGCCACCCACAAGAGCAGCAGGGTGTCCAGCCTCTTACTGGCTGC
CACTCTGGGCTCGACAGTGTTACAGAAGGACCAAAAGATGTCAGAGAGGCCCCCTCTCAA
AGTCATCTCAAGGAACAAAGTTTACAGCCCATTGACTCTTTGATTTCAGCTCTGAAAGCC
ACAGAAGCCAGAATCATTTCCGGAACATTACAGGCTACAAAGGTACTGGACCAAGATGCT
GTTTCTAGTTTTTCAGTTCAGCAGGTGGAAAAAGAGCTGGACACTGCCAGTCGTAAAACA
CAGAGAGTCAACAAAACGCTCCCTGCTGGCCAAAAAAATTTACCAGAAATACCTCTTTCA
GCTGAAGTAACAACGGAGGAAAGTTTTTATTTGAGCATCCAGAAAGATCTCACCGCGCTG
TTAACTGGAGACACTCAGGCAGAGATTTCCCAGATAATGAATAATGGGAGGAAAGGGGCT
GTCTGTGTGCAGGAGCCATCTTGTCCTTTGGCCTCCCTCGGGAGCTCAGCAGTGACCTGC
CACTCTGCAGGCAGTGTTGGTTTCTTGAAAGAGCAGAGGTCTGCTCTTGGGAGAGAGCAC
CCAGGGGGATGTGATCGAAGCAGCTCCATGGGACGCCCAGGCCGGGTCAAACATGTGGAA
TTTCAAGGAGTGGAAATACTGTGGACAGGAGGAGACAAGAGAGAGACCCAGCATCCTATA
GATTTTGAGACATCACTGCAAAGAACAGCCTCTCCTGACAGCAAAGAGTCTTCCAAAGTG
CCACGCCATCTCATCTCATCAGCTGGTTTGTGTAATTCAAGTAGTTTAACTGAGAATGTT
TGGGATGAATCCTGGAAAGCTCCTTCAGAGAGGCCTGGCACTAGCTCGGGGACATTTTCC
CCTGTGCGTCTTGATGAGAGTGGAGAGGATGAAGTCTTCCTACAGGAAAACAAACAGCAT
CTTGAGAAGACACCTAAACCAGAGAGAGACAGGGAAAGGATCAGCGAACAAGAGGAGCAC
GTTAAGGGGGAAGATGAAGACATCCTTGGGCCTGGATATACGGAGGACTCCACCGACGTG
TACAGCTCCCAGTTTGAAACCATTTTGGACAACACTTCTTTATACTACAGTGCAGAGTCC
CTGGAGACATTATACTCAGAGCCTGATAGCTATTTTAGCTTTGAAATGCCCCTCACTCCA
ATGATACAACAGCGCATTAAAGAAGGTGGTCAGTTCTTGGAGAGGACATCAGGGGGAGGA
CATCAGGATATCCTGAGTGTGTCTGCAGATGGTGGCATCGTGATGGGCTATTCTAGTGGC
GTCACCAATGGGCTGAATGATGCCAGCGACTCCATCTACACGAAAGGCACCCCGGAGATT
GCTTTCTGGGGAAGCAATGCTGGGGTGAAAACAACACGGCTAGAAGCTCATTCTGAAATG
GGGAGCACTGAAATTTTGGAAAAGGAGACCCCAGAAAATCTCAGTAATGGTACCAGCAGC
AATGTGGAAGCAGCCAAAAGGTTGGCCAAACGCCTTTATCAGCTGGACAGATTCAAAAGA
TCAGATGTTGCAAAACACCTTGGCAAGAACAACGAATTTAGCAAACTAGTTGCAGAAGAA
TATCTGAAGTTTTTTGATTTTACAGGAATGACGCTGGATCAGTCACTCAGGTATTTCTTT
AAAGCATTCTCTCTTGTGGGAGAAACTCAAGAACGAGAGAGAGTTTTAATACACTTCTCC
AATAGATATTTTTATTGTAACCCAGATACCATTGCTTCACAAGATGGAGTCCATTGCCTT
ACCTGTGCAATAATGCTTCTTAATACCGATCTACATGGCCACAATATTGGAAAGAAGATG
ACCTGTCAGGAGTTCATTGCAAATCTGCAAGGGGTAAATGAGGGTGTTGATTTCTCCAAG
GATCTGCTGAAAGCTCTGTACAACTCAATCAAGAATGAGAAGCTTGAATGGGCAGTAGAT
GATGAAGAGAAAAAAAAGTCTCCCTCAGAAAGTACTGAGGAGAAAGCTAACGGAACACAT
CCAAAGACCATCAGTCGTATTGGAAGTACTACTAACCCATTTTTGGACATTCCTCATGAT
CCAAATGCTGCTGTGTACAAAAGTGGATTCTTGGCTCGGAAAATTCATGCAGATATGGAT
GGAAAGAAGACTCCAAGAGGAAAACGAGGATGGAAAACCTTTTATGCTGTACTGAAGGGA
ACAGTTCTTTACTTGCAAAAGGATGAATACAAGCCAGAAAAGGCCTTGTCTGAAGAGGAC
TTGAAAAACGCTGTGAGTGTGCACCACGCATTGGCATCCAAGGCCACGGACTATGAGAAG
AAACCAAACGTGTTTAAACTTAAAACTGCCGACTGGAGGGTCTTGCTTTTTCAAACTCAG
AGCCCAGAGGAAATGCAAGGGTGGATAAACAAAATCAATTGTGTGGCAGCTGTATTTTCT
GCACCACCATTTCCAGCAGCAATCGGCTCTCAGAAGAAGTTTAGCCGCCCACTTCTGCCT
GCCACTACAACAAAACTGTCTCAGGAGGAGCAACTGAAGTCACATGAAAGTAAGCTGAAG
CAGATCACCACCGAGCTGGCCGAGCACCGCTCATATCCCCCCGACAAGAAGGTCAAAGCC
AAGGACGTCGATGAGTACAAACTGAAAGACCACTATCTGGAGTTTGAGAAAACCCGCTAT
GAAATGTATGTCAGCATTCTCAAGGAAGGAGGCAAAGAGCTACTGAGTAACGATGAAAGC
GAGGCTGCAGGACTGAAGAAGTCGCACTCGAGTCCTTCGCTGAACCCGGATACTTCTCCA
ATCACTGCCAAAGTCAAGCGTAACGTGTCAGAGAGGAAGGATCACCGACCTGAAACACCA
AGCATTAAGCAAAAAGTTACTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1048 |
| Molecular Weight
| 116032.6 |
| Theoretical pI
| 5.85 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>PH and SEC7 domain-containing protein 3
MEGRSAAAETFVWVNNASAHSQSVAKAKYEFLFGRSEGKAPDTSDHGGSTLLPPNVTNEF
PEYGTMEEGGEGLRASLEFDGEALPCHPQEQQGVQPLTGCHSGLDSVTEGPKDVREAPSQ
SHLKEQSLQPIDSLISALKATEARIISGTLQATKVLDQDAVSSFSVQQVEKELDTASRKT
QRVNKTLPAGQKNLPEIPLSAEVTTEESFYLSIQKDLTALLTGDTQAEISQIMNNGRKGA
VCVQEPSCPLASLGSSAVTCHSAGSVGFLKEQRSALGREHPGGCDRSSSMGRPGRVKHVE
FQGVEILWTGGDKRETQHPIDFETSLQRTASPDSKESSKVPRHLISSAGLCNSSSLTENV
WDESWKAPSERPGTSSGTFSPVRLDESGEDEVFLQENKQHLEKTPKPERDRERISEQEEH
VKGEDEDILGPGYTEDSTDVYSSQFETILDNTSLYYSAESLETLYSEPDSYFSFEMPLTP
MIQQRIKEGGQFLERTSGGGHQDILSVSADGGIVMGYSSGVTNGLNDASDSIYTKGTPEI
AFWGSNAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKR
SDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFS
NRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHVNIGKKMTCQEFIANLQGVNEGVDFS
KDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPFLDIPH
DPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEE
DLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVF
SAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVK
AKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSLNPDTS
PITAKVKRNVSERKDHRPETPSIKQKVT
|
| External Links |
|---|
| GenBank ID Protein
| 117606360 |
| UniProtKB/Swiss-Prot ID
| Q9NYI0 |
| UniProtKB/Swiss-Prot Entry Name
| PSD3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_015310 |
| GeneCard ID
| PSD3 |
| GenAtlas ID
| PSD3 |
| HGNC ID
| HGNC:19093 |
| References |
|---|
| General References
| Not Available |