| Identification |
|---|
| HMDB Protein ID
| CDBP05050 |
| Secondary Accession Numbers
| Not Available |
| Name
| Epithelial cell-transforming sequence 2 oncogene-like |
| Description
| Not Available |
| Synonyms
|
- Lung-specific F-box and DH domain-containing protein
- Putative guanine nucleotide exchange factor LFDH
|
| Gene Name
| ECT2L |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in Rho guanyl-nucleotide exchange factor activity |
| Specific Function
| May act as a guanine nucleotide exchange factor (GEF) |
| GO Classification
|
| Component |
| intracellular |
| cell part |
| Function |
| small gtpase regulator activity |
| ras guanyl-nucleotide exchange factor activity |
| rho guanyl-nucleotide exchange factor activity |
| enzyme regulator activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| Process |
| regulation of ras protein signal transduction |
| regulation of rho protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6q24.1 |
| SNPs
| ECT2L |
| Gene Sequence
|
>2715 bp
ATGGAGAGCTTCCACACCAGATTTAGTGCCTGGACACCTTTTAGCAACAAGTCATTAAAT
AGACAGCTCTTTCAGGAAAGAGTGGCTCTTATAAGTCATTGGTTTGACCTCTGGACTAAC
AAGCAACGTCAAGAATTCTTATTCGCAATTTTTTTAAGATGCACTAAATCACAATTAAGG
TTTGTCCAAGACTGGTTTTCAGAAAGGATGCAAGTGGCCAAAGTGGACTTCTCTACAGTG
TTACCACGCTTCATTTCTCTATATATCTTTTCCTTTTTGAGTCCGAAAGATTTGTGTGCC
GCTGCCCAAGTCAGCTGGCCCTGGAAGTTTTTAACTGAACAGGATTGCTTATGGATGCCC
AAATGCGTTAAGTTCGGATGGTTTCTGCCCTATACTCCAACAGATAATGAGTATGGTGCT
TGGAAGCGCCATTACATTGCTTGTGTGTCCCACTTAGACTGGCTGACACCTAGGGAGGCT
GCTGCTACTTATGGGACGCTGAATGAACCCAAAACAGAAGATGAGGAACTACTGGAGAGA
CAAAGAGAAAAGTGCCTGAGGAAAAGAATTTGGGAGAAAATTGCACTACGTAAGAAGGAG
TTATTCAAAGTTCGACCCCCTTGGGTGAGTGGAACTTGCTGCTCTAGCGTGCTAAAGCCC
AGATGCCAACCACGCCTCTCCCAGACTGTAAGGGAGCGAGTGGGATTACATGAAGCTTTG
GAGAAACAGCTTGTTTTGACATCGTTAGAAACCTTGCCCAAGCGAAGCAATATTTCTGGA
AGCCATTCCTACCCTTTATTATCAAAGAAAAATTGGCATGGAGTTCATAAAAATGATGAC
AGATCTTCATATGCTCTCCGGCCACACTTCATGTTAATATCATCCCGGATTCCTGCGTAT
GAGATGGTGATGGAGAGTGTGAAGGCTGGTGTTGTTTCTGTGGTATATGAACACAGCGTA
ACCTTGGAAAGCCTTCTGTATCTTATAGAAAAAGCTCTGGATGGGCAGAAGGCACAGAGC
ATCGGAATATTTAGCGATGGAGACAGCAGAGAAATCAATTTACTCCAAGGCTATAAAATT
GGTGTTAAAAATTTACTGAGGCCTGAAGTGAGAGATTTCTGGGAGAAATTAGGAAGCTAT
GTGGCCACTGAAGAAGAAGGGGGTCACGTGGACTTCTTCGTGCCCCTTGGAGCATCAGAG
GCAGGAATTGAAGTTCTTTCCCAGCTGTCTCAACTAACTGGCACGTTCTTTACGGCCCCC
ACTGGGATTGCAACTGGCTCTTACCAGCACATTCTTAGTGATTGGCTGGGATCCCAATGG
GGAAAGGCCCCCTCTTCCATCTACTTCTGCGAATCGAAGCTACAGACGTGGTCCAGCTTC
ACAGACTTCCTAGAAGAAACCTTGAAAACAGTAAGGAAGCAGCTGTATCCTTTCTTCAAG
GAACTGCAGAAGAGCATCAGTGGCAGGATGATAGGGCAGTTTATGTTTGACACCATGGGT
ATGACCAACATTCTAAACAACCAAGATACTGCGCAAGCTCTGGCAGATGGATTGATGGAG
TTGTCAAAAGAAGATTCTGAAAGAAATGTTGTAGAAGACAATTCTTGGGACACAAAGTCC
AGGCTCAGCAAAAATGATTTAAATTTTGAAGCACTGATTAATCTGGAGAGAATACTCCAG
AAGGACTCAGCAGAAAAGCGAGCTAGAGTTGTCAGAGAACTCTTACAGAGTGAGAGAAAA
TACGTGCAGATACTGGAAATTGTGAGAGATGTTTATGTCGCACCACTGAAAGCAGCATTG
TCATCAAACAGAGCGATTCTGAGTGCTGCCAATATCCAGATCATTTTCTGTGACATTCTA
CAGATTTTAAGTCTCAACAGGCAGTTTCTAGATAACCTGAGAGACAGACTGCAGGAATGG
GGCCCAGCTCACTGTGTGGGAGAAATAGTCACGAAGTTTGGAAGCCAGTTAAACACATAT
ACCAATTTCTTCAACAATTACCCTGTCATTCTGAAAACTATTGAGAAGTGCAGAGAAATG
ATACCAGCATTCCGAACTTTCCTGAAGAGGCATGATAAGACCATTGTTACCAAAATGCTG
AGCCTGCCAGAGCTGCTGCTGTACCCATCCCGAAGATTTGAAGAATACCTTAATCTTCTC
TACGCTGTCAGGCTTCATACCCCTGCAGAGCATGTTGACCGTGGGGACTTGACCACTGCA
ATTGACCAAATCAAAAAATATAAAGGTTATATAGATCAGATGAAGCAAAACATCACTATG
AAGGATCATCTGTCAGATATACAGAGAATCATCTGGGGATGCCCTACTCTATCAGAAGTA
AACAGATATCTGATTAGGGTACAAGATGTAGCCCAACTTCATTGCTGTGATGAAGAAATA
AGTTTCTCTTTAAGGCTCTATGAACACATCCATGATCTCAGCCTTTTCCTCTTCAATGAT
GCCCTGCTCGTTTCTAGTCGGGGCACATCTCACACTCCATTTGAGAGGACTTCAAAAACA
ACCTACCAGTTCATTGCATCAGTGGCCCTTCATCGGTTACTCATAGAAAATATTCCAGAT
TCCAAGTATGTCAAGAATGCATTTATTCTTCAGGGTCCAAAATATAAATGGATTTGTGCT
ACAGAAATAGAGGATGATAAGTTCCTATGGCTGTCAGTACTTCGAAATGCAATCAAAAGC
AGTATGGAGAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 904 |
| Molecular Weight
| 104878.7 |
| Theoretical pI
| 8.52 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Epithelial cell-transforming sequence 2 oncogene-like
MESFHTRFSAWTPFSNKSLNRQLFQERVALISHWFDLWTNKQRQEFLFAIFLRCTKSQLR
FVQDWFSERMQVAKVDFSTVLPRFISLYIFSFLSPKDLCAAAQVSWPWKFLTEQDCLWMP
KCVKFGWFLPYTPTDNEYGAWKRHYIACVSHLDWLTPREAAATYGTLNEPKTEDEELLER
QREKCLRKRIWEKIALRKKELFKVRPPWVSGTCCSSVLKPRCQPRLSQTVRERVGLHEAL
EKQLVLTSLETLPKRSNISGSHSYPLLSKKNWHGVHKNDDRSSYALRPHFMLISSRIPAY
EMVMESVKAGVVSVVYEHSVTLESLLYLIEKALDGQKAQSIGIFSDGDSREINLLQGYKI
GVKNLLRPEVRDFWEKLGSYVATEEEGGHVDFFVPLGASEAGIEVLSQLSQLTGTFFTAP
TGIATGSYQHILSDWLGSQWGKAPSSIYFCESKLQTWSSFTDFLEETLKTVRKQLYPFFK
ELQKSISGRMIGQFMFDTMGMTNILNNQDTAQALADGLMELSKEDSERNVVEDNSWDTKS
RLSKNDLNFEALINLERILQKDSAEKRARVVRELLQSERKYVQILEIVRDVYVAPLKAAL
SSNRAILSAANIQIIFCDILQILSLNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTY
TNFFNNYPVILKTIEKCREMIPAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLL
YAVRLHTPAEHVDRGDLTTAIDQIKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEV
NRYLIRVQDVAQLHCCDEEISFSLRLYEHIHDLSLFLFNDALLVSSRGTSHTPFERTSKT
TYQFIASVALHRLLIENIPDSKYVKNAFILQGPKYKWICATEIEDDKFLWLSVLRNAIKS
SMEK
|
| External Links |
|---|
| GenBank ID Protein
| 220675550 |
| UniProtKB/Swiss-Prot ID
| Q008S8 |
| UniProtKB/Swiss-Prot Entry Name
| ECT2L_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AL121834 |
| GeneCard ID
| ECT2L |
| GenAtlas ID
| ECT2L |
| HGNC ID
| HGNC:21118 |
| References |
|---|
| General References
| Not Available |