| Identification |
|---|
| HMDB Protein ID
| CDBP05045 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rho guanine nucleotide exchange factor 6 |
| Description
| Not Available |
| Synonyms
|
- Alpha-Pix
- COOL-2
- PAK-interacting exchange factor alpha
- Rac/Cdc42 guanine nucleotide exchange factor 6
|
| Gene Name
| ARHGEF6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in Rho guanyl-nucleotide exchange factor activity |
| Specific Function
| Acts as a RAC1 guanine nucleotide exchange factor (GEF) |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| small gtpase regulator activity |
| ras guanyl-nucleotide exchange factor activity |
| rho guanyl-nucleotide exchange factor activity |
| enzyme regulator activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| Process |
| regulation of ras protein signal transduction |
| regulation of rho protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| ARHGEF6 |
| Gene Sequence
|
>2331 bp
ATGAATCCAGAAGAACAAATCGTGACATGGCTTATATCTTTGGGAGTTTTAGAGTCCCCT
AAAAAGACCATCTGTGATCCGGAGGAGTTTTTAAAGTCCTCGCTGAAAAATGGGGTAGTT
CTGTGCAAACTGATCAACAGACTCATGCCTGGCTCTGTGGAAAAGTTTTGTCTGGATCCC
CAAACTGAAGCTGACTGCATCAACAACATCAATGACTTCCTGAAAGGATGTGCAACCCTC
CAAGTGGAAATATTTGATCCTGATGACCTTTATTCAGGGGTCAATTTCTCCAAGGTACTG
AGTACTCTTTTAGCTGTCAACAAAGCAACAGAAGATCAGCTATCAGAAAGACCATGTGGA
CGTTCCTCTTCTCTTAGTGCTGCTAATACTTCTCAGACAAACCCACAGGGAGCAGTTTCT
AGCACAGTTTCAGGGCTGCAAAGGCAGTCAAAGACAGTGGAGATGACGGAAAATGGAAGT
CATCAGTTGATAGTAAAAGCAAGATTCAACTTTAAGCAGACTAATGAGGATGAACTGTCA
GTTTGTAAGGGGGACATCATTTACGTCACACGAGTTGAAGAAGGAGGCTGGTGGGAAGGC
ACATTAAATGGGAGAACAGGCTGGTTCCCCAGTAATTATGTCCGTGAAATTAAATCCAGT
GAGAGACCTCTCTCCCCAAAAGCCGTCAAAGGATTTGAAACTGCTCCACTTACCAAGAAT
TATTATACTGTGGTGTTACAGAACATCCTGGACACTGAAAAAGAATATGCTAAAGAACTT
CAGTCTCTTCTTGTTACTTACTTAAGACCCCTGCAGTCCAATAACAATCTGAGTACTGTG
GAGGTTACATCTTTACTGGGAAACTTCGAGGAAGTATGCACATTTCAACAGACACTCTGC
CAAGCCTTGGAAGAATGTTCAAAGTTTCCAGAAAACCAGCACAAAGTAGGAGGTTGTCTA
CTGAGTCTCATGCCTCATTTTAAATCTATGTATCTGGCTTACTGTGCAAACCATCCTTCA
GCTGTAAATGTGCTCACTCAGCACAGTGATGAGTTGGAACAATTCATGGAAAATCAAGGT
GCATCGAGCCCAGGTATCCTCATTTTAACAACAAACCTCAGCAAACCATTCATGCGACTG
GAGAAATATGTTACTCTCTTGCAAGAGTTAGAACGGCATATGGAGGATACTCATCCAGAT
CATCAGGATATTCTGAAAGCAATCGTAGCATTCAAAACTCTCATGGGGCAATGTCAAGAT
CTGAGGAAGAGAAAACAGCTGGAGTTACAGATACTGTCCGAACCTATTCAGGCATGGGAA
GGAGAAGATATTAAAAACTTGGGAAATGTGATTTTTATGTCACAAGTAATGGTGCAGTAT
GGAGCATGTGAGGAAAAAGAGGAGCGGTACCTTATGTTATTTTCAAATGTCCTGATAATG
TTATCTGCAAGTCCTCGGATGAGTGGCTTTATCTATCAGGGAAAAATACCAATAGCAGGA
ACGGTGGTGACTAGATTAGATGAAATTGAAGGGAATGACTGCACATTTGAAATCACTGGT
AACACAGTGGAGAGAATTGTGGTCCATTGTAACAACAACCAGGACTTCCAGGAATGGTTG
GAGCAGCTGAACAGACTGATCAGAGGACCTGCCTCTTGCAGTTCATTATCCAAAACCTCA
TCGTCATCATGTAGTGCTCATTCTTCTTTTAGCTCTACCGGACAGCCCCGAGGACCCTTG
GAGCCTCCTCAAATTATAAAACCGTGGAGTTTAAGTTGTCTACGACCTGCACCTCCACTT
AGACCATCAGCAGCACTAGGTTATAAAGAGAGGATGTCTTATATCTTAAAGGAGTCTAGT
AAAAGCCCTAAAACGATGAAGAAATTTCTTCATAAAAGGAAGACTGAGAGAAAACCATCG
GAGGAGGAATATGTGATTAGGAAAAGTACAGCTGCTCTGGAAGAGGATGCTCAAATCCTT
AAAGTGATCGAAGCCTACTGCACCAGCGCAAATTTTCAACAAGGCCATGGCTCAAGTACT
CGAAAAGATTCCATTCCACAAGTCCTACTCCCTGAGGAAGAGAAACTCATCATTGAAGAA
ACCAGAAGCAACGGCCAGACCATCATGGAAGAAAAGAGCCTTGTTGATACTGTTTACGCC
TTGAAGGACGAGGTCAGAGAACTGAAGCAGGAAAATAAAAGAATGAAGCAATGCCTGGAA
GAAGAACTGAAATCAAGAAGGGACCTAGAAAAGCTGGTGCGGAGGCTTTTGAAGCAAACA
GATGAGTGTATTCGAGGCGAGTCCAGTAGCAAGACCTCAATTCTTCCATAA
|
| Protein Properties |
|---|
| Number of Residues
| 776 |
| Molecular Weight
| 87498.1 |
| Theoretical pI
| 5.9 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rho guanine nucleotide exchange factor 6
MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDP
QTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATEDQLSERPCG
RSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELS
VCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKAVKGFETAPLTKN
YYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLC
QALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMENQG
ASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQD
LRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLMLFSNVLIM
LSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEWL
EQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPL
RPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQIL
KVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTVYA
LKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGESSSKTSILP
|
| External Links |
|---|
| GenBank ID Protein
| 22027525 |
| UniProtKB/Swiss-Prot ID
| Q15052 |
| UniProtKB/Swiss-Prot Entry Name
| ARHG6_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_004840.2 |
| GeneCard ID
| ARHGEF6 |
| GenAtlas ID
| ARHGEF6 |
| HGNC ID
| HGNC:685 |
| References |
|---|
| General References
| Not Available |