| Identification |
|---|
| HMDB Protein ID
| CDBP05026 |
| Secondary Accession Numbers
| Not Available |
| Name
| Elongation of very long chain fatty acids protein 1 |
| Description
| Not Available |
| Synonyms
|
- 3-keto acyl-CoA synthase ELOVL1
- ELOVL fatty acid elongase 1
- Very-long-chain 3-oxoacyl-CoA synthase 1
- ELOVL FA elongase 1
|
| Gene Name
| ELOVL1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids. Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis.
|
| GO Classification
|
| Biological Process |
| fatty acid elongation, monounsaturated fatty acid |
| fatty acid elongation, saturated fatty acid |
| very long-chain fatty acid biosynthetic process |
| sphingolipid biosynthetic process |
| long-chain fatty-acyl-CoA biosynthetic process |
| triglyceride biosynthetic process |
| Cellular Component |
| integral to endoplasmic reticulum membrane |
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Molecular Function |
| fatty acid elongase activity |
|
| Cellular Location
|
- Multi-pass membrane protein (Potential)
- Endoplasmic reticulum membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Fatty acid elongation | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p34.2 |
| SNPs
| ELOVL1 |
| Gene Sequence
|
>840 bp
ATGGAGGCTGTTGTGAACTTGTACCAAGAGGTGATGAAGCACGCAGATCCCCGGATCCAG
GGCTACCCTCTGATGGGGTCCCCCTTGCTAATGACCTCCATTCTCCTGACCTACGTGTAC
TTCGTTCTCTCACTTGGGCCTCGCATCATGGCTAATCGGAAGCCCTTCCAGCTCCGTGGC
TTCATGATTGTCTACAACTTCTCACTGGTGGCACTCTCCCTCTACATTGTCTATGAGTTC
CTGATGTCGGGCTGGCTGAGCACCTATACCTGGCGCTGTGACCCTGTGGACTATTCCAAC
AGCCCTGAGGCACTTAGGATGGTTCGGGTGGCCTGGCTCTTCCTCTTCTCCAAGTTCATT
GAGCTGATGGACACAGTGATCTTTATTCTCCGAAAGAAAGACGGGCAGGTGACCTTCCTA
CATGTCTTCCATCACTCTGTGCTTCCCTGGAGCTGGTGGTGGGGGGTAAAGATTGCCCCG
GGAGGAATGGGCTCTTTCCATGCCATGATAAACTCTTCCGTGCATGTCATAATGTACCTG
TACTACGGATTATCTGCCTTTGGCCCTGTGGCACAACCCTACCTTTGGTGGAAAAAGCAC
ATGACAGCCATTCAGCTGATCCAGTTTGTCCTGGTCTCACTGCACATCTCCCAGTACTAC
TTTATGTCCAGCTGTAACTACCAGTACCCAGTCATTATTCACCTCATCTGGATGTATGGC
ACCATCTTCTTCATGCTGTTCTCCAACTTCTGGTATCACTCTTATACCAAGGGCAAGCGG
CTGCCCCGTGCACTTCAGCAAAATGGAGCTCCAGGTATTGCCAAGGTCAAGGCCAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 279 |
| Molecular Weight
| 32662.49 |
| Theoretical pI
| 9.602 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Elongation of very long chain fatty acids protein 1
MEAVVNLYQEVMKHADPRIQGYPLMGSPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRG
FMIVYNFSLVALSLYIVYEFLMSGWLSTYTWRCDPVDYSNSPEALRMVRVAWLFLFSKFI
ELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYL
YYGLSAFGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYG
TIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKAN
|
| External Links |
|---|
| GenBank ID Protein
| 13489093 |
| UniProtKB/Swiss-Prot ID
| Q9BW60 |
| UniProtKB/Swiss-Prot Entry Name
| ELOV1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_022821.2 |
| GeneCard ID
| ELOVL1 |
| GenAtlas ID
| ELOVL1 |
| HGNC ID
| HGNC:14418 |
| References |
|---|
| General References
| Not Available |