| Identification |
|---|
| HMDB Protein ID
| CDBP05025 |
| Secondary Accession Numbers
| Not Available |
| Name
| Elongation of very long chain fatty acids protein 2 |
| Description
| Not Available |
| Synonyms
|
- 3-keto acyl-CoA synthase ELOVL2
- ELOVL fatty acid elongase 2
- Very-long-chain 3-oxoacyl-CoA synthase 2
- ELOVL FA elongase 2
|
| Gene Name
| ELOVL2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in fatty acid biosynthetic process |
| Specific Function
| Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA.
|
| GO Classification
|
| Biological Process |
| alpha-linolenic acid metabolic process |
| linoleic acid metabolic process |
| long-chain fatty-acyl-CoA biosynthetic process |
| triglyceride biosynthetic process |
| very long-chain fatty acid biosynthetic process |
| fatty acid elongation, polyunsaturated fatty acid |
| Cellular Component |
| endoplasmic reticulum membrane |
| integral to membrane |
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Molecular Function |
| fatty acid elongase activity |
|
| Cellular Location
|
- Multi-pass membrane protein (Potential)
- Endoplasmic reticulum membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Fatty acid elongation | Not Available |  | | Biosynthesis of unsaturated fatty acids | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6p24.2 |
| SNPs
| ELOVL2 |
| Gene Sequence
|
>891 bp
ATGGAACATCTAAAGGCCTTTGATGATGAAATCAATGCTTTTTTGGACAATATGTTTGGA
CCGCGAGATTCTCGAGTCAGAGGGTGGTTCACGTTGGACTCTTACCTTCCTACCTTTTTT
CTTACTGTCATGTATCTGCTCTCAATATGGCTGGGTAACAAGTATATGAAGAACAGACCT
GCTCTTTCTCTCAGGGGTATCCTCACCTTGTATAATCTTGGAATCACACTTCTCTCCGCG
TACATGCTGGCAGAGCTCATTCTCTCCACTTGGGAAGGAGGCTACAACTTACAGTGTCAA
GATCTTACCAGCGCAGGGGAAGCTGACATCCGGGTAGCCAAGGTGCTTTGGTGGTACTAT
TTCTCCAAATCAGTAGAGTTCCTGGACACAATTTTCTTCGTTTTGCGGAAAAAAACGAGT
CAGATTACTTTTCTTCATGTATATCATCATGCTTCTATGTTTAACATCTGGTGGTGTGTC
TTGAACTGGATACCTTGTGGACAAAGTTTCTTTGGACCAACACTGAACAGTTTTGTCCAC
ATTCTTATGTACTCCTACTATGGACTTTCTGTGTTTCCATCTATGCACAAGTATCTTTGG
TGGAAGAAATATCTCACACAGGCTCAGCTGGTGCAGTTCGTGCTCACCATCACGCACACC
ATGAGCGCCGTCGTGAAACCGTGTGGCTTCCCCTTCGGTTGTCTCATCTTCCAGTCATCT
TATATGCTAACGTTAGTCATCCTCTTCTTAAATTTTTATGTTCAGACATACCGAAAAAAG
CCAATGAAGAAAGATATGCAAGAGCCACCTGCAGGGAAAGAAGTGAAGAATGGTTTTTCC
AAAGCCTACTTCACTGCAGCAAATGGAGTGATGAACAAGAAAGCACAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 296 |
| Molecular Weight
| 34584.435 |
| Theoretical pI
| 9.255 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Elongation of very long chain fatty acids protein 2
MEHLKAFDDEINAFLDNMFGPRDSRVRGWFMLDSYLPTFFLTVMYLLSIWLGNKYMKNRP
ALSLRGILTLYNLGITLLSAYMLAELILSTWEGGYNLQCQDLTSAGEADIRVAKVLWWYY
FSKSVEFLDTIFFVLRKKTSQITFLHVYHHASMFNIWWCVLNWIPCGQSFFGPTLNSFIH
ILMYSYYGLSVFPSMHKYLWWKKYLTQAQLVQFVLTITHTMSAVVKPCGFPFGCLIFQSS
YMLTLVILFLNFYVQTYRKKPMKKDMQEPPAGKEVKNGFSKAYFTAANGVMNKKAQ
|
| External Links |
|---|
| GenBank ID Protein
| 7020361 |
| UniProtKB/Swiss-Prot ID
| Q9NXB9 |
| UniProtKB/Swiss-Prot Entry Name
| ELOV2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK000341 |
| GeneCard ID
| ELOVL2 |
| GenAtlas ID
| ELOVL2 |
| HGNC ID
| HGNC:14416 |
| References |
|---|
| General References
| Not Available |