| Identification |
|---|
| HMDB Protein ID
| CDBP05002 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein very KIND |
| Description
| Not Available |
| Synonyms
|
- Cerebral protein 9
- KIND domain-containing protein 1
- Kinase non-catalytic C-lobe domain-containing protein 1
- Ras-GEF domain-containing family member 2
|
| Gene Name
| KNDC1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in guanyl-nucleotide exchange factor activity |
| Specific Function
| Probable guanine nucleotide exchange factor (GEF) |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| enzyme regulator activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| guanyl-nucleotide exchange factor activity |
| Process |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| intracellular signal transduction |
| small gtpase mediated signal transduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q26.3 |
| SNPs
| KNDC1 |
| Gene Sequence
|
>5250 bp
ATGCAGGCCATGGACCCGGCCGCGGCGGATCTTTACGAGGAGGACGGCAAAGACCTGGAC
TTCTACGACTTCGAGCCGCTGCCCACCCTCCCCGAGGACGAGGAGAACGTGTCTCTGGCT
GACATCCTCTCCCTGCGGGACCGCGGCCTCAGCGAGCAGGAAGCCTGGGCCGTGTGCCTG
GAGTGCAGCCTGTCCATGCGGAGCGTGGCCCACGCCGCCATCTTCCAGAGCCTGTGCATC
ACGCCCGACACCCTGGCCTTCAACACCAGCGGGAACGTGTGTTTCATGGAGCAGCTCAGC
GACGACCCTGAGGGTGCCTTCGTTCCCCCCGAGTTCGACGTGACCGGGAACACCTTTGAG
GCGCACATCTACTCTCTGGGGGCCACGCTGAAGGCCGCCCTCGAGTACGTGGCAGAGCCC
ACACTGGAACCCAGGCTGAGCCAAGACCTCGAGGCGCTGCTGAGCCGGATGCAGGCGGAG
GACCCCGGGGACCGGCCGGACCTTGAGAGCATCATCGCGCTGTGTGAAGAGAAGCTGCAG
CTCACATCCTCCTGTCGCGTGTGCCGGAGCCTCTCTGCTGTGGGGAGGAGGGTCCTCTCC
ATCGAGTCCTTCGGAGCGCTGCAGGATGTCAGCGAGAGCAGCTGGCGGGAGAGACCTGCC
CCAGGAAACGCTGGGCCCAGGAGGCCGCCCGGGGACCCCAGCACTGACCCGGAGGTTCTG
CCGACCCCCGAAGGCCCGGAGTCTGAGACGAGCCGGGGCCCCAGAGCCTCCCCAACCAAG
GCTCTGCTGTCCACCCCGGTGAGAAATGGCGAGAGCCACAGCCGGGAGGGGCTGGCCGGC
CTCGTCCTGGATGCCGAGCGCACCCTCGGGGAGCTGGACAGAGACGCCCTCAGGAGAAGC
CGCCTGCGGAAGGTGCAGACGTTCCCTAGGCTGCTGTCCGACAGCCCCGAGGCCACCCTC
TGCCTGCCGCTGACCCGCGGGAAAAGCCAGCTGCCCATATCGGAATTATTCTCTCCGGAC
CCCAGGAAGGCCTTTCTGGACAGGAAAAATGGCCTTTCTAGCTTCCAGGCTCAGCCCAAA
TGCAGGCTGTGGCCGGAGCAGGAGCCGGAACACCAGCTGGGACGGGTTCCCTGTGCAGGC
CGCAGCACGGACAGGGGCCCTGGGGTGCCCGGCAGTCCAGGACAGCCCGAGACTTCACAC
CCCAGCCAGGGGCCAGCAGAGGCCCCTGCAGACCCTCGAGATGCTAGCGGTGAAGCCCAG
ACTCCCAGGGACGATGAGAGAATTCCAGAAGGAGCTAGGCAGCTGGAAAGTGCAGCCGCG
GAGCAGTGGGTGTCCCTGCAGGACCTCCTGTCCCAGCTGGGCCGGCCCTTCCGGGAGTAC
GAGCTGTGGGCCCTGTGCCTGGCCTGCCTCCGCGCACTGCAGACACGCCCTGAGCACCCA
GCCTACCTGTGTCTGGACTCCGTGCTGGTTGCTGAGGACGGGGCTGTGCTCTTCCAGCCA
CCCCCTGCCAACGGTTCCTATGACTCGTTCTTTCTGGCTCCCGAGCTGGCAGAGGAGAGG
CTGGTAACTGAAAAGGCCTCTGTGTACTGTGTGGCCGCCGTTCTGTGGACCGCAGCCAAG
TTCAGCGTCCCCCGCAACCACAAGCTGGCCCTGCCACGCAGGCTCAAGACCCTCCTCCTG
GACATGGCCAGGCGCAGTGCCCCGGAGCGGCCGTCCGCGGCTGAGGCCATCAAGGTGTGC
GGCAGCTACCTCCTCCAGCGAGGCATGGACAGCCGGAAAATCCTTGCCCACCTCAGAGCT
TCCATCTGCCAGGTGTACCAGGAGGAAGAGACCATCAGCCTCCAAAACGCCTTCTCAGTG
GTTGAACTGAAGCCCAGTGTGGCACCAGCCCCAGAGCCCAGCCCAGGCTTCCTGCCGGTG
AACAGCGACACCGGGCTTGTGGCTGTGCCAGGGCCCGTGCCCGGCCAGCACCCCTGCGGT
GAAGAAGCCACCCAGCTGCCTGCAGCGTTCACCTCCGAGGCCACGCACTTCAAGCCCATT
GTCCTCGCGCAGAACGCAAGTGTGGCCAGGGACCAGCCTGCCTTGGCCCAGGAGGAGTCC
GAGGAGAGGGGCGGCCAGAGGGAGGGAGAAGGTGAGGAGAAGCTCTCCCTGGAGGCCCAC
GCTGGGTCCCCCAGCCTGAAGACGCCTGACGGGCCGGTGCCTGGTCCGGGGCCACAGGGA
GCAGCCCCAGAGCCTCTTGGGGCGTCAGTGCAGCGTGACTCAGCCCAGGGCCGCCCCTGC
CCTCCACCCCAGGCCCCAGCAAACCAGCCAGAGGGGGCCTCATCGGCAGCTCCCGGCTCT
CCAGTCCCCGCCCCGCCCACGAAGGCATCTGCGCTGCCCGTAGAGCAAGGGCCGGCTGAG
CCGATCCCACCTGGAGTTGCTTCCGGGGGCCTCAGGCCCGACGCCCTGGGGCCCACCACG
GCCCACCACGGCCCACGCCACCCGCCCAAGCCCCCACGAAGCAAGGCCACCGAGCGCCCG
GGCCAGGAGCCAGAGGGCCCCGGGGCCACCCCTGCCGGGGAACGTGATGACCAGAGTCCA
GACAGTGTCCCAGAGAGGCCGCGGCCCGCAGACCGGAGGCTCTGTCTGCCCTGCGTGGAT
GCCTCGCCACTCCCAGGGAGGACGGCCTGCCCGTCGCTGCAGGAGGCCACGCGCCTCATC
CAGGAGGAATTTGCCTTCGATGGCTACCTGGACAATGGGCTGGAGGCTCTGATCATGGGG
GAGTACATCTTCGCCTTGAAAGATCTCACCTTTGCCACTTTCTGTGGCGCCATTTCCGAG
AAGTTCTGTGACCTGTACTGGGATGAGAAGTTGCTGCAGAACCTCTTTAAGGTGGTCAAC
GGGCAGGCGTCACCCTCCCCAAGCACGGCCGAGGAGGCTGGGTCACAGCTCGAGGGCAGC
CAAAGCCCCCGCTCCCCGTCCAGCAAGAGGCCGTCGCTGCACCGCCTGGGAAAAGAGAAG
CCAGCCATGGCCAGGACCAGCAGCAGGGCCCCCTGCTCACCCACCTCGGTGTCGGATGTG
GACTCGGACGCACTGTCACGGGGAAACTTCGAGGTGGGGTTTCGGCCTCAGAGGTCCGTA
AAAGCCGAGAGAGCGCAGCAGCCTGAGGCTGGCGAGGACAGACGGCCAGCTGGCGGGGCC
TCAGACGTGGAGGCAGTGACCCGACTGGCCAGGTCCAAAGGGGTCGGCCCAGCCTTGTCC
CCCGGCCCAGCCGGATTCCAGAGCTGCAGCCCCGGCTGGTGCAGCGCCTTCTACGAGGCC
GACTGCTTCGGGGCCGACGTCCACAACTACGTGAAGGACCTGGGGCGGCAGCAGGCGGAC
GGGGCCCTGCCCGACGCCCAGAGCCCGGAGCTGGAACAGCAGCTCATGATGGAGAAAAGA
AACTACCGCAAGACCCTGAAGTTCTACCAGAAACTCTTACAGAAGGAAAAGAGGAACAAA
GGTTCCGACGTCAAGACCATGCTGTCCAAGCTGAAAGGGCAGCTAGAAGAAATGAAATCC
AGGGTGCAATTCCTCAGCTTGGTCAAGAAGTATCTGCAGGTCATGTACGCGGAACGCTGG
GGCCTGGAGCCCTGCACCCTCCCAGTGATCGTGAACATCGCGGCCGCACCCTGCGACACG
CTGGACTTCAGCCCCCTGGACGAGTCCTCCTCGCTCATCTTCTACAACGTCAACAAGCAC
CCGGGCGGCCGGCAGAAGGCCCGCATCCTGCAGGCCGGCACGCCGCTGGGGCTCATGGCC
TACCTGTACTCCAGTGATGCCTTCCTGGAGGGTTATGTGCAGCAATTCCTCTACACCTTC
CGCTACTTCTGCACACCCCACGACTTCCTGCACTTCCTCCTCGACCGCATCAACAGCACG
CTGACCAGGGCCCACCAGGACCCCACCTCGACCTTCACCAAGATCTACAGGCGGAGCCTC
TGCGTCCTGCAGGCCTGGGTGGAGGACTGCTACGCTGTGGACTTCCCTCGGAACAGCGGG
CTGCTGGGGAAGCTAGAGGACTTCATCTCCTCCAAGATCCTACCCCTGGACGGCTCTGCC
AAGCACCTGCTGGGCCTCCTGGAGGTGGGCATGGACCGGCGGGCCGAGGGCAACCCTCGC
GGCACAGACCTGGAGAACCCCAGGGAGGCCGAGGAGGATGCCAGACCCTTCAACGCCCTC
TGTAAGAGGCTCTCAGAGGACGGCATCTCCAGGAAGAGCTTCCCCTGGAGGCTGCCCCGA
GGCAACGGGCTGGTGCTGCCGCCACACAAGGAGCGCCCCTACACCATTGCTGCCGCCCTG
CCCAAGCCCTGCTTCCTCGAGGACTTCTACGGCCCCTGCGCCAAGACCAGTGAGAAGGGG
CCCTACTTCCTGACGGAGTACAGCACTCACCAGCTCTTCAGCCAGCTCACGCTGCTACAG
CAGGAGTTGTTTCAAAAGTGCCACCCGGTCCACTTCCTGAACTCACGGGCCCTGGGCGTC
ATGGACAAGAGCACTGCCATCCCCAAAGCCAGCTCTTCTGAGTCTCTTTCGGCCAAAACC
TGCAGCTTATTTCTGCCCAATTACGTTCAGGACAAGTATCTGTTACAGCTTCTAAGAAAC
GCAGATGACGTCAGCACCTGGGTGGCTGCAGAGATTGTGACCAGCCACACCTCCAAGCTG
CAGGTGAACTTGCTGTCCAAATTTTTGCTGATTGCAAAATCTTGCTATGAGCAGAGAAAC
TTCGCGACAGCCATGCAGATCCTGAGCGGGCTGGAGCACCTGGCCGTGAGGCAGTCCCCT
GCCTGGAGAATTCTGCCTGCAAAGATAGCAGAGGTCATGGAGGAGCTGAAAGCCGTGGAG
GTCTTCCTGAAGAGCGACAGCCTGTGTCTGATGGAAGGGCGGCGCTTCCGGGCGCAGCCC
ACCCTGCCCTCGGCCCACCTCCTGGCCATGCACATCCAGCAGCTGGAGACAGGCGGCTTC
ACCATGACCAACGGGGCCCACAGGTGGAGCAAGCTCAGGAACATCGCAAAGGTGGTGAGC
CAGGTGCACGCGTTCCAGGAGAACCCTTACACCTTCAGCCCCGACCCCAAGCTCCAGTCG
TACCTCAAGCAGAGGATTGCCCGCTTCAGCGGTGCCGACATTTCCACACTCGCCGCAGAT
AGCAGGGCCAACTTCCACCAGGTCTCCAGCGAGAAGCACTCACGGAAGATTCAGGACAAG
CTACGGAGGATGAAGGCTACATTCCAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1749 |
| Molecular Weight
| 191394.3 |
| Theoretical pI
| 6.07 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protein very KIND
MQAMDPAAADLYEEDGKDLDFYDFEPLPTLPEDEENVSLADILSLRDRGLSEQEAWAVCL
ECSLSMRSVAHAAIFQSLCITPDTLAFNTSGNVCFMEQLSDDPEGAFVPPEFDVTGNTFE
AHIYSLGATLKAALEYVAEPTLEPRLSQDLEALLSRMQAEDPGDRPDLESIIALCEEKLQ
LTSSCRVCRSLSAVGRRVLSIESFGALQDVSESSWRERPAPGNAGPRRPPGDPSTDPEVL
PTPEGPESETSRGPRASPTKALLSTPVRNGESHSREGLAGLVLDAERTLGELDRDALRRS
RLRKVQTFPRLLSDSPEATLCLPLTRGKSQLPISELFSPDPRKAFLDRKNGLSSFQAQPK
CRLWPEQEPEHQLGRVPCAGRSTDRGPGVPGSPGQPETSHPSQGPAEAPADPRDASGEAQ
TPRDDERIPEGARQLESAAAEQWVSLQDLLSQLGRPFREYELWALCLACLRALQTRPEHP
AYLCLDSVLVAEDGAVLFQPPPANGSYDSFFLAPELAEERLVTEKASVYCVAAVLWTAAK
FSVPRNHKLALPRRLKTLLLDMARRSAPERPSAAEAIKVCGSYLLQRGMDSRKILAHLRA
SICQVYQEEETISLQNAFSVVELKPSVAPAPEPSPGFLPVNSDTGLVAVPGPVPGQHPCG
EEATQLPAAFTSEATHFKPIVLAQNASVARDQPALAQEESEERGGQREGEGEEKLSLEAH
AGSPSLKTPDGPVPGPGPQGAAPEPLGASVQRDSAQGRPCPPPQAPANQPEGASSAAPGS
PVPAPPTKASALPVEQGPAEPIPPGVASGGLRPDALGPTTAHHGPRHPPKPPRSKATERP
GQEPEGPGATPAGERDDQSPDSVPERPRPADRRLCLPCVDASPLPGRTACPSLQEATRLI
QEEFAFDGYLDNGLEALIMGEYIFALKDLTFATFCGAISEKFCDLYWDEKLLQNLFKVVN
GQASPSPSTAEEAGSQLEGSQSPRSPSSKRPSLHRLGKEKPAMARTSSRAPCSPTSVSDV
DSDALSRGNFEVGFRPQRSVKAERAQQPEAGEDRRPAGGASDVEAVTRLARSKGVGPALS
PGPAGFQSCSPGWCSAFYEADCFGADVHNYVKDLGRQQADGALPDAQSPELEQQLMMEKR
NYRKTLKFYQKLLQKEKRNKGSDVKTMLSKLKGQLEEMKSRVQFLSLVKKYLQVMYAERW
GLEPCTLPVIVNIAAAPCDTLDFSPLDESSSLIFYNVNKHPGGRQKARILQAGTPLGLMA
YLYSSDAFLEGYVQQFLYTFRYFCTPHDFLHFLLDRINSTLTRAHQDPTSTFTKIYRRSL
CVLQAWVEDCYAVDFPRNSGLLGKLEDFISSKILPLDGSAKHLLGLLEVGMDRRAEGNPR
GTDLENPREAEEDARPFNALCKRLSEDGISRKSFPWRLPRGNGLVLPPHKERPYTIAAAL
PKPCFLEDFYGPCAKTSEKGPYFLTEYSTHQLFSQLTLLQQELFQKCHPVHFLNSRALGV
MDKSTAIPKASSSESLSAKTCSLFLPNYVQDKYLLQLLRNADDVSTWVAAEIVTSHTSKL
QVNLLSKFLLIAKSCYEQRNFATAMQILSGLEHLAVRQSPAWRILPAKIAEVMEELKAVE
VFLKSDSLCLMEGRRFRAQPTLPSAHLLAMHIQQLETGGFTMTNGAHRWSKLRNIAKVVS
QVHAFQENPYTFSPDPKLQSYLKQRIARFSGADISTLAADSRANFHQVSSEKHSRKIQDK
LRRMKATFQ
|
| External Links |
|---|
| GenBank ID Protein
| 116268127 |
| UniProtKB/Swiss-Prot ID
| Q76NI1 |
| UniProtKB/Swiss-Prot Entry Name
| VKIND_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_152643.6 |
| GeneCard ID
| KNDC1 |
| GenAtlas ID
| KNDC1 |
| HGNC ID
| HGNC:29374 |
| References |
|---|
| General References
| Not Available |