| Identification |
|---|
| HMDB Protein ID
| CDBP04952 |
| Secondary Accession Numbers
| Not Available |
| Name
| Beta-chimaerin |
| Description
| Not Available |
| Synonyms
|
- Beta-chimerin
- Rho GTPase-activating protein 3
|
| Gene Name
| CHN2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in intracellular signaling pathway |
| Specific Function
| GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| binding |
| protein binding |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| intracellular signaling pathway |
| signaling |
| signaling pathway |
|
| Cellular Location
|
- Membrane
- Peripheral membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:7 |
| Locus
| 7p15.3 |
| SNPs
| CHN2 |
| Gene Sequence
|
>1407 bp
ATGGCAGCGTCCAGCAACTCCAGCCTGTCCGGCTCGTCGGTGTCCTCCGATGCTGAAGAA
TACCAGCCTCCTATATGGAAATCATACTTATATCAGTTACAGCAAGAGGCACCTCGTCCC
AAGAGAATCATTTGTCCTCGGGAGGTGGAAAACAGACCAAAATATTATGGAAGAGAGTTT
CATGGGATCATCTCTCGGGAGCAGGCGGATGAGCTTCTTGGAGGCGTGGAGGGTGCCTAC
ATCCTTAGAGAAAGCCAGCGGCAACCAGGATGCTACACGCTGGCTCTCAGGTTTGGAAAC
CAGACCTTAAACTACAGGCTCTTCCACGACGGGAAACACTTTGTGGGTGAGAAGAGGTTT
GAGTCGATTCATGATCTGGTGACAGATGGCTTGATAACACTGTACATAGAAACAAAAGCT
GCCGAGTACATTTCAAAAATGACAACTAACCCCATCTATGAACACATTGGATATGCCACC
CTACTCAGAGAAAAAGTATCCAGAAGGCTGAGCAGGTCTAAAAATGAACCAAGAAAAACA
AACGTCACACATGAAGAACACACAGCGGTGGAAAAGATCTCCTCCCTGGTTCGAAGGGCT
GCCCTCACACACAACGACAACCACTTCAATTATGAGAAGACACACAACTTTAAGGTCCAC
ACGTTCCGAGGCCCACACTGGTGTGAATATTGTGCCAATTTCATGTGGGGGCTCATCGCC
CAAGGGGTCCGGTGCTCAGACTGTGGATTGAACGTACACAAACAGTGTTCCAAGCACGTT
CCCAATGACTGCCAACCTGATCTCAAGAGGATCAAGAAAGTGTACTGTTGTGACCTCACA
ACACTTGTGAAGGCTCACAACACTCAGAGACCCATGGTGGTAGACATATGCATTCGGGAA
ATTGAAGCAAGAGGATTAAAATCGGAAGGCCTTTACAGAGTCTCTGGGTTCACTGAACAC
ATTGAAGATGTCAAAATGGCATTTGACAGAGATGGTGAAAAGGCCGATATATCTGCCAAT
GTCTATCCAGACATAAACATCATCACTGGAGCCCTTAAACTGTATTTCAGAGACTTACCC
ATCCCTGTCATCACATATGATACCTATTCCAAATTTATAGATGCAGCAAAAATCTCCAAT
GCAGATGAGAGGCTGGAAGCCGTCCATGAAGTGCTGATGCTGCTGCCTCCTGCCCACTAT
GAAACCCTCCGGTACCTAATGATCCACCTCAAAAAGGTTACTATGAATGAAAAAGACAAT
TTCATGAATGCAGAAAATCTGGGGATCGTGTTTGGGCCCACTCTGATGAGGCCCCCTGAG
GACAGCACCCTGACCACCCTGCATGATATGCGGTACCAAAAGCTGATTGTGCAGATTTTA
ATAGAAAACGAAGACGTTTTATTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 468 |
| Molecular Weight
| 53923.1 |
| Theoretical pI
| 7.45 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Beta-chimaerin
MAASSNSSLSGSSVSSDAEEYQPPIWKSYLYQLQQEAPRPKRIICPREVENRPKYYGREF
HGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHFVGEKRF
ESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVSRRLSRSKNEPRKT
NVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIA
QGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIRE
IEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLP
IPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDN
FMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF
|
| External Links |
|---|
| GenBank ID Protein
| 4757980 |
| UniProtKB/Swiss-Prot ID
| P52757 |
| UniProtKB/Swiss-Prot Entry Name
| CHIO_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_004067.2 |
| GeneCard ID
| CHN2 |
| GenAtlas ID
| CHN2 |
| HGNC ID
| HGNC:1944 |
| References |
|---|
| General References
| Not Available |