Showing Protein Pleckstrin homology domain-containing family M member 1 (CDBP04950)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 16 compounds
Identification
HMDB Protein ID CDBP04950
Secondary Accession Numbers Not Available
Name Pleckstrin homology domain-containing family M member 1
Description Not Available
Synonyms
  1. 162 kDa adapter protein
  2. AP162
  3. PH domain-containing family M member 1
Gene Name PLEKHM1
Protein Type Enzyme
Biological Properties
General Function Involved in intracellular signaling pathway
Specific Function Involved in vesicular transport in the osteoclast. May have a role in sialyl-lex-mediated transduction of apoptotic signals
GO Classification
Process
intracellular signaling pathway
signaling
signaling pathway
Cellular Location
  1. Cytoplasm (Potential)
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 17q21.31
SNPs PLEKHM1
Gene Sequence 
>3171 bp
ATGCTTTCAGTGGTGGAGAATGGACTGGACCCCCAGGCTGCCATCCCGGTCATCAAGAAG
AAGCTGGTGGGATCCGTGAAGGCCTTGCAGAAGCAGTACGTGTCCCTGGACACGGTGGTC
ACTAGTGAAGACGGAGATGCCAACACCATGTGCAGCGCCCTGGAGGCCGTATTTATCCAT
GGCCTGCACGCCAAGCACATCCGAGCTGAGGCCGGAGGAAAAAGGAAGAAAAGTGCCCAC
CAGAAGCCTCTGCCCCAGCCTGTCTTCTGGCCCCTCCTGAAAGCTGTCACCCACAAACAC
ATCATCTCAGAGTTGGAGCACCTGACGTTTGTCAACACGGATGTGGGCCGCTGCCGGGCA
TGGCTGCGGCTGGCCCTGAACGATGGCCTGATGGAGTGCTACCTGAAGCTGCTGCTGCAG
GAGCAGGCCCGCTTGCATGAGTACTACCAGCCCACCGCCCTGCTCCGGGATGCTGAGGAG
GGCGAGTTCCTCCTTAGCTTCCTGCAGGGCCTCACGTCCTTGTCCTTCGAACTCTCCTAC
AAGTCTGCCATCTTAAATGAGTGGACGCTCACCCCATTGGCCCTGTCTGGGCTTTGCCCG
CTTTCTGAGCTGGACCCTCTCTCTACCTCTGGTGCAGAACTACAGCGGAAGGAATCTCTG
GATTCCATTTCCCATTCTTCAGGCTCTGAAGACATCGAAGTCCATCACTCGGGCCATAAG
ATACGGAGGAACCAGAAGCTGACTGCCTCCTCCCTCAGCCTGGACACGGCCAGTTCATCC
CAGCTGTCCTGCAGCCTAAACTCTGATAGCTGCTTACTCCAAGAGAATGGCTCCAAGAGT
CCAGACCATTGCGAGGAGCCCATGTCCTGTGACTCAGACCTGGGCACAGCAAATGCTGAG
GACTCAGACCGGTCTCTGCAAGAGGTATTGTTGGAATTCAGCAAAGCCCAGGTAAACTCT
GTGCCAACCAACGGACTGAGCCAAGAAACAGAGATCCCCACACCACAGGCCTCGCTCTCC
CTCCATGGCCTCAACACCAGCACATACCTGCACTGTGAGGCACCTGCAGAGCCCCTTCCT
GCCCAGGCAGCCTCTGGAACTCAAGATGGTGTCCACGTGCAGGAGCCGCGTCCCCAGGCG
CCCAGCCCCCTGGACTTACAGCAGCCTGTAGAGAGCACCTCAGGCCAGCAGCCTTCTAGT
ACTGTCAGCGAGACAGCCAGAGAAGTGGGCCAAGGGAATGGCCTGCAGAAGGCCCAGGCT
CATGACGGAGCTGGTCTGAAGCTGGTAGTTTCCTCACCCACCAGTCCGAAAAACAAGAGC
TGGATCTCAGAGGATGACTTCTACCGGCCTTCCCGGGAGCAACCCCTGGAGAGTGCTTCA
GACCACCCAATAGCTTCTTACAGGGGGACTCCAGGGTCAAGGCCTGGTCTCCACAGGCAT
TTTTCTCAAGAACCAAGAAAAAACTGCTCCCTGGGGGCGTTAGACCAAGCGTGTGTACCT
TCCCCAGGAAGAAGGCAAGCCCAGGCAGCCCCATCCCAGGGGCATAAGAGCTTCCGGGTG
GTACACCGGAGACAGATGGGACTGTCCAACCCATTCCGGGGTCTCATGAAGCTGGGCACC
GTGGAGCGGCGGGGGGCAATGGGCATCTGGAAGGAGCTCTTCTGCGAGCTCTCCCCGCTG
GAGTTCCGCCTCTACCTGAGCAACGAGGAGCACACCTGTGTGGAGAACTGCTCGCTGCTT
CGCTGTGAGTCTGTGGGGCCAGCCCATAGTGATGGGCGCTTTGAGCTGGTCTTCTCTGGC
AAGAAGCTGGCCCTGCGCGCCTCCTCCCAGGACGAAGCTGAGGACTGGCTGGACCGGGTG
CGGGAGGCCCTGCAGAAGGTCCGGCCTCAGCAGGAGGATGAGTGGGTGAACGTGCAGTAC
CCAGACCAGCCTGAGGAACCCCCCGAGGCGCCCCAGGGCTGCCTCTCTCCCTCAGACCTG
CTCTCGGAGCCCGCGGCCCTCCAGGGCACACAGTTTGACTGGTCGTCCGCCCAGGTTCCA
GAGCCAGATGCCATCAAGGAGTCCCTGCTGTACTTGTACATGGACAGGACCTGGATGCCC
TATATATTTTCTCTGTCCTTGGAGGCTCTGAAATGTTTCCGCATCAGGAACAATGAGAAG
ATGCTGAGTGACAGCCACGGCGTGGAGACCATCCGGGACATCCTGCCAGACACCAGCCTT
GGGGGCCCATCCTTCTTCAAAATCATCACGGCCAAGGCTGTCCTGAAGCTGCAGGCCGGA
AACGCCGAGGAAGCCGCCCTGTGGAGGGATCTGGTCCGCAAAGTCCTGGCATCCTACTTG
GAGACAGCCGAGGAGGCGGTGACCCTGGGCGGGAGCCTGGATGAAAACTGTCAGGAGGTG
CTGAAATTTGCCACCCGGGAGAATGGCTTCCTGCTGCAGTACCTGGTGGCTATCCCCATG
GAGAAAGGCCTTGACTCCCAAGGCTGCTTCTGCGCAGGCTGCTCCCGGCAGATCGGCTTC
TCCTTTGTACGACCCAAGCTCTGTGCCTTCTCTGGCCTCTATTACTGTGACATCTGCCAC
CAAGACGATGCCTCAGTGATTCCGGCCAGGATCATCCACAACTGGGACCTCACCAAGCGC
CCGATCTGCAGGCAGGCCCTGAAGTTTCTGACACAGATCCGGGCCCAGCCCCTCATCAAC
CTGCAGATGGTGAACGCGTCTCTGTACGAGCATGTGGAGCGGATGCACCTCATTGGGAGG
AGACGGGAGCAGCTGAAGCTCCTGGGGGATTACCTGGGCCTGTGCCGGAGTGGCGCCCTG
AAGGAGCTCAGCAAGAGGCTCAACCACAGGAATTATCTCTTGGAATCTCCGCATAGGTTC
AGTGTTGCTGACCTCCAACAGATCGCAGACGGGGTGTATGAAGGATTCCTCAAGGCCCTG
ATTGAATTTGCCTCCCAGCATGTCTACCACTGCGACCTGTGCACCCAGCGCGGCTTCATC
TGCCAGATCTGCCAGCACCACGACATCATCTTCCCCTTTGAGTTTGACACCACAGTCAGG
TGTGCCGAGTGCAAGACCGTCTTCCACCAGAGCTGCCAGGCTGTGGTGAAGAAGGGCTGC
CCCCGCTGTGCCCGCCGGCGCAAGTACCAGGAACAGAACATTTTCGCCTGA
Protein Properties
Number of Residues 1056
Molecular Weight 117442.0
Theoretical pI 6.5
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Pleckstrin homology domain-containing family M member 1
MLSVVENGLDPQAAIPVIKKKLVGSVKALQKQYVSLDTVVTSEDGDANTMCSALEAVFIH
GLHAKHIRAEAGGKRKKSAHQKPLPQPVFWPLLKAVTHKHIISELEHLTFVNTDVGRCRA
WLRLALNDGLMECYLKLLLQEQARLHEYYQPTALLRDAEEGEFLLSFLQGLTSLSFELSY
KSAILNEWTLTPLALSGLCPLSELDPLSTSGAELQRKESLDSISHSSGSEDIEVHHSGHK
IRRNQKLTASSLSLDTASSSQLSCSLNSDSCLLQENGSKSPDHCEEPMSCDSDLGTANAE
DSDRSLQEVLLEFSKAQVNSVPTNGLSQETEIPTPQASLSLHGLNTSTYLHCEAPAEPLP
AQAASGTQDGVHVQEPRPQAPSPLDLQQPVESTSGQQPSSTVSETAREVGQGNGLQKAQA
HDGAGLKLVVSSPTSPKNKSWISEDDFYRPSREQPLESASDHPIASYRGTPGSRPGLHRH
FSQEPRKNCSLGALDQACVPSPGRRQAQAAPSQGHKSFRVVHRRQMGLSNPFRGLMKLGT
VERRGAMGIWKELFCELSPLEFRLYLSNEEHTCVENCSLLRCESVGPAHSDGRFELVFSG
KKLALRASSQDEAEDWLDRVREALQKVRPQQEDEWVNVQYPDQPEEPPEAPQGCLSPSDL
LSEPAALQGTQFDWSSAQVPEPDAIKESLLYLYMDRTWMPYIFSLSLEALKCFRIRNNEK
MLSDSHGVETIRDILPDTSLGGPSFFKIITAKAVLKLQAGNAEEAALWRDLVRKVLASYL
ETAEEAVTLGGSLDENCQEVLKFATRENGFLLQYLVAIPMEKGLDSQGCFCAGCSRQIGF
SFVRPKLCAFSGLYYCDICHQDDASVIPARIIHNWDLTKRPICRQALKFLTQIRAQPLIN
LQMVNASLYEHVERMHLIGRRREQLKLLGDYLGLCRSGALKELSKRLNHRNYLLESPHRF
SVADLQQIADGVYEGFLKALIEFASQHVYHCDLCTQRGFICQICQHHDIIFPFEFDTTVR
CAECKTVFHQSCQAVVKKGCPRCARRRKYQEQNIFA
GenBank ID Protein 40538728
UniProtKB/Swiss-Prot ID Q9Y4G2
UniProtKB/Swiss-Prot Entry Name PKHM1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_014798.2
GeneCard ID PLEKHM1
GenAtlas ID PLEKHM1
HGNC ID HGNC:29017
References
General References Not Available