| Identification |
|---|
| HMDB Protein ID
| CDBP04939 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phospholipase DDHD2 |
| Description
| Not Available |
| Synonyms
|
- DDHD domain-containing protein 2
- SAM, WWE and DDHD domain-containing protein 1
|
| Gene Name
| DDHD2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in metal ion binding |
| Specific Function
| Phospholipase that hydrolyzes preferentially phosphatidic acid and phosphatidylethanolamine. May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
|
| Cellular Location
|
- Cytoplasm
- Cytoplasmic granule
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8p11.23 |
| SNPs
| DDHD2 |
| Gene Sequence
|
>2136 bp
ATGTCATCAGTGCAGTCACAACAGGAGCAGTTGTCCCAGTCAGATCCATCTCCGTCACCA
AACTCATGTAGTTCCTTTGAGCTAATAGACATGGATGCTGGCAGCTTGTATGAACCAGTT
TCTCCCCATTGGTTTTATTGTAAGATAATAGATTCTAAGGAGACATGGATTCCTTTCAAC
TCTGAGGATTCACAGCAGCTGGAAGAGGCATATAGCTCTGGAAAAGGTTGTAATGGGAGA
GTTGTTCCTACTGATGGGGGCAGATATGATGTTCATTTGGGGGAGAGGATGCGGTATGCT
GTATACTGGGATGAACTGGCATCGGAAGTGAGACGATGTACGTGGTTTTACAAGGGGGAC
AAAGACAATAAGTATGTTCCCTACTCGGAGAGCTTCAGCCAAGTTTTAGAGGAAACTTAC
ATGCTTGCTGTAACTTTGGATGAATGGAAAAAGAAACTGGAATCTCCCAACAGAGAAATT
ATTATTTTACACAATCCAAAGCTTATGGTGCATTACCAGCCAGTTGCAGGGTCTGATGAT
TGGGGTTCAACACCCACGGAGCAGGGTCGACCAAGAACTGTGAAGAGAGGAGTTGAGAAC
ATCTCTGTTGACATTCATTGTGGAGAACCTTTACAAATAGATCACTTGGTTTTTGTAGTC
CATGGGATTGGACCAGCTTGTGATCTCCGCTTTCGAAGCATTGTACAGTGTGTTAATGAT
TTTCGCAGTGTTTCCTTGAACTTGCTACAGACACATTTTAAGAAAGCCCAAGAAAATCAG
CAGATTGGGAGGGTAGAATTTCTTCCAGTCAACTGGCACAGTCCTTTGCATTCTACTGGT
GTGGATGTAGATCTGCAGCGAATAACCCTGCCCAGCATTAACCGCCTCAGGCACTTCACC
AATGACACAATTCTGGATGTCTTCTTCTACAATAGTCCCACCTACTGTCAGACTATTGTG
GACACAGTTGCTTCTGAAATGAACCGAATATACACACTTTTTCTACAGAGGAACCCTGAT
TTCAAAGGGGGTGTATCCATTGCTGGTCATAGTTTAGGTTCGCTTATATTGTTTGATATC
CTAACAAATCAGAAAGATTCTTTGGGGGATATTGACAGTGAAAAGGATTCGCTAAATATT
GTAATGGATCAAGGAGATACACCTACACTAGAGGAAGATTTGAAGAAACTTCAGCTCTCT
GAATTCTTTGATATCTTTGAGAAGGAGAAAGTAGATAAGGAAGCTCTGGCTTTATGTACA
GACCGAGATCTTCAGGAAATAGGAATTCCTTTAGGACCAAGAAAGAAGATATTAAACTAT
TTCAGCACCAGAAAAAACTCAATGGGTATTAAGAGACCAGCCCCGCAGCCTGCTTCAGGG
GCAAACATCCCCAAAGAATCTGAGTTCTGCAGTAGCAGTAATACTAGAAATGGTGACTAT
CTGGATGTTGGCATTGGGCAGGTGTCTGTGAAATACCCCCGGCTCATCTATAAACCAGAG
ATATTCTTTGCCTTTGGATCTCCCATTGGAATGTTCCTTACTGTCCGAGGACTAAAAAGA
ATTGATCCCAACTACAGATTTCCAACGTGCAAAGGTTTCTTCAATATTTATCACCCTTTT
GATCCTGTGGCCTATAGGATTGAACCAATGGTGGTCCCAGGAGTGGAATTTGAGCCAATG
CTGATCCCACATCATAAAGGCAGGAAGCGGATGCACTTAGAACTGAGAGAGGGCTTGACC
AGGATGAGTATGGACCTTAAGAACAACTTGCTAGGTTCGCTGCGGATGGCCTGGAAGTCT
TTTACCAGAGCTCCATACCCTGCCTTACAAGCTTCAGAAACACCAGAAGAAACTGAAGCA
GAACCTGAATCAACTTCAGAGAAGCCTAGTGATGTTAACACAGAAGAGACCTCTGTGGCA
GTTAAAGAAGAAGTCCTGCCTATCAATGTGGGGATGCTGAATGGAGGCCAACGCATTGAC
TATGTGCTACAGGAGAAGCCTATTGAAAGTTTTAATGAGTATTTATTTGCTTTACAAAGC
CATCTATGCTACTGGGAGTCTGAAGATACAGTATTGCTCGTCCTCAAAGAGATCTACCAA
ACCCAGGGTATCTTCCTTGATCAGCCTTTACAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 711 |
| Molecular Weight
| 81031.1 |
| Theoretical pI
| 5.05 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Phospholipase DDHD2
MSSVQSQQEQLSQSDPSPSPNSCSSFELIDMDAGSLYEPVSPHWFYCKIIDSKETWIPFN
SEDSQQLEEAYSSGKGCNGRVVPTDGGRYDVHLGERMRYAVYWDELASEVRRCTWFYKGD
KDNKYVPYSESFSQVLEETYMLAVTLDEWKKKLESPNREIIILHNPKLMVHYQPVAGSDD
WGSTPTEQGRPRTVKRGVENISVDIHCGEPLQIDHLVFVVHGIGPACDLRFRSIVQCVND
FRSVSLNLLQTHFKKAQENQQIGRVEFLPVNWHSPLHSTGVDVDLQRITLPSINRLRHFT
NDTILDVFFYNSPTYCQTIVDTVASEMNRIYTLFLQRNPDFKGGVSIAGHSLGSLILFDI
LTNQKDSLGDIDSEKDSLNIVMDQGDTPTLEEDLKKLQLSEFFDIFEKEKVDKEALALCT
DRDLQEIGIPLGPRKKILNYFSTRKNSMGIKRPAPQPASGANIPKESEFCSSSNTRNGDY
LDVGIGQVSVKYPRLIYKPEIFFAFGSPIGMFLTVRGLKRIDPNYRFPTCKGFFNIYHPF
DPVAYRIEPMVVPGVEFEPMLIPHHKGRKRMHLELREGLTRMSMDLKNNLLGSLRMAWKS
FTRAPYPALQASETPEETEAEPESTSEKPSDVNTEETSVAVKEEVLPINVGMLNGGQRID
YVLQEKPIESFNEYLFALQSHLCYWESEDTVLLVLKEIYQTQGIFLDQPLQ
|
| External Links |
|---|
| GenBank ID Protein
| 256017247 |
| UniProtKB/Swiss-Prot ID
| O94830 |
| UniProtKB/Swiss-Prot Entry Name
| DDHD2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001164232.1 |
| GeneCard ID
| DDHD2 |
| GenAtlas ID
| DDHD2 |
| HGNC ID
| HGNC:29106 |
| References |
|---|
| General References
| Not Available |