| Identification |
|---|
| HMDB Protein ID
| CDBP04936 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 |
| Description
| Not Available |
| Synonyms
|
- E-NPP 6
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 soluble form
- NPP-6
- Choline-specific glycerophosphodiester phosphodiesterase
- Glycerophosphocholine cholinephosphodiesterase
- GPC-Cpde
|
| Gene Name
| ENPP6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid.
|
| GO Classification
|
| Biological Process |
| choline metabolic process |
| lipid catabolic process |
| lipid metabolic process |
| Cellular Component |
| plasma membrane |
| extracellular region |
| integral to membrane |
| Function |
| catalytic activity |
| Molecular Function |
| glycerophosphocholine cholinephosphodiesterase activity |
| glycerophosphodiester phosphodiesterase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
- Cell membrane
- Secreted
- Single-pass type I membrane protein (Probable)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Ether lipid metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4q35.1 |
| SNPs
| ENPP6 |
| Gene Sequence
|
>1323 bp
ATGGCAGTGAAGCTTGGGACCCTCCTGCTGGCCCTTGCCCTGGGCCTGGCCCAGCCAGCC
TCTGCCCGCCGGAAGCTGCTGGTGTTTCTGCTGGATGGTTTTCGCTCAGACTACATCAGT
GATGAGGCGCTGGAGTCATTGCCTGGTTTCAAAGAGATTGTGAGCAGGGGAGTAAAAGTG
GATTACTTGACTCCAGACTTCCCTAGTCTCTCGTATCCCAATTATTATACCCTAATGACT
GGCCGCCATTGTGAAGTCCATCAGATGATCGGGAACTACATGTGGGACCCCACCACCAAC
AAGTCCTTTGACATTGGCGTCAACAAAGACAGCCTAATGCCTCTCTGGTGGAATGGATCA
GAACCTCTGTGGGTCACTCTGACCAAGGCCAAAAGGAAGGTCTACATGTACTACTGGCCA
GGCTGTGAGGTTGAGATTCTGGGTGTCAGACCCACCTACTGCCTAGAATATAAAAATGTC
CCAACGGATATCAATTTTGCCAATGCAGTCAGCGATGCTCTTGACTCCTTCAAGAGTGGC
CGGGCCGACCTGGCAGCCATATACCATGAGCGCATTGACGTGGAAGGCCACCACTACGGG
CCTGCATCTCCGCAGAGGAAAGATGCCCTCAAGGCTGTAGACACTGTCCTGAAGTACATG
ACCAAGTGGATCCAGGAGCGGGGCCTGCAGGACCGCCTGAACGTCATTATTTTCTCGGAT
CACGGAATGACCGACATTTTCTGGATGGACAAAGTGATTGAGCTGAATAAGTACATCAGC
CTGAATGACCTGCAGCAAGTGAAGGACCGCGGGCCTGTTGTGAGCCTTTGGCCGGCCCCT
GGGAAACACTCTGAGATATATAACAAACTGAGCACAGTGGAACACATGACTGTCTACGAG
AAAGAAGCCATCCCAAGCAGGTTCTATTACAAGAAAGGAAAGTTTGTCTCTCCTTTGACT
TTAGTGGCTGATGAAGGCTGGTTCATAACTGAGAATCGAGAGATGCTTCCGTTTTGGATG
AACAGCACCGGCAGGCGGGAAGGTTGGCAGCGTGGATGGCACGGCTACGACAACGAGCTC
ATGGACATGCGGGGCATCTTCCTGGCCTTCGGACCTGATTTCAAATCCAACTTCAGAGCT
GCTCCTATCAGGTCGGTGGACGTCTACAATGTCATGTGCAATGTGGTGGGCATCACCCCG
CTGCCCAACAACGGATCCTGGTCCAGGGTGATGTGCATGCTGAAGGGCCGCGCCAGCACT
GCCCCGCCTGTCTGGCCCAGCCACTGTGCCCTGGCACTGATTCTTCTCTTCCTGCTTGCA
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 440 |
| Molecular Weight
| 50240.625 |
| Theoretical pI
| 7.981 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ectonucleotide pyrophosphatase/phosphodiesterase family member 6
MAVKLGTLLLALALGLAQPASARRKLLVFLLDGFRSDYISDEALESLPGFKEIVSRGVKV
DYLTPDFPSLSYPNYYTLMTGRHCEVHQMIGNYMWDPTTNKSFDIGVNKDSLMPLWWNGS
EPLWVTLTKAKRKVYMYYWPGCEVEILGVRPTYCLEYKNVPTDINFANAVSDALDSFKSG
RADLAAIYHERIDVEGHHYGPASPQRKDALKAVDTVLKYMTKWIQERGLQDRLNVIIFSD
HGMTDIFWMDKVIELNKYISLNDLQQVKDRGPVVSLWPAPGKHSEIYNKLSTVEHMTVYE
KEAIPSRFYYKKGKFVSPLTLVADEGWFITENREMLPFWMNSTGRREGWQRGWHGYDNEL
MDMRGIFLAFGPDFKSNFRAAPIRSVDVYNVMCNVVGITPLPNNGSWSRVMCMLKGRAST
APPVWPSHCALALILLFLLA
|
| External Links |
|---|
| GenBank ID Protein
| 16553045 |
| UniProtKB/Swiss-Prot ID
| Q6UWR7 |
| UniProtKB/Swiss-Prot Entry Name
| ENPP6_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK057370 |
| GeneCard ID
| ENPP6 |
| GenAtlas ID
| ENPP6 |
| HGNC ID
| HGNC:23409 |
| References |
|---|
| General References
| Not Available |