| Identification |
|---|
| HMDB Protein ID
| CDBP04912 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ras-responsive element-binding protein 1 |
| Description
| Not Available |
| Synonyms
|
- Finger protein in nuclear bodies
- RREB-1
- Raf-responsive zinc finger protein LZ321
- Zep-1
- Zinc finger motif enhancer-binding protein 1
|
| Gene Name
| RREB1 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| Transcription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1 |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
| nucleic acid binding |
|
| Cellular Location
|
- Nucleus speckle
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6p25 |
| SNPs
| RREB1 |
| Gene Sequence
|
>5064 bp
ATGACGTCAAGTTCGCCCGCTGGCTTGGAAGGTTCAGACCTATCTTCCATCAACACCATG
ATGTCGGCGGTCATGAGTGTAGGGAAGGTCACAGAGAATGGCGGGAGCCCCCAGGGGATC
AAGTCCCCCTCGAAGCCTCCAGGACCAAATCGGATTGGCAGAAGGAACCAGGAAACGAAA
GAGGAGAAGTCTTCCTATAACTGCCCCCTGTGTGAGAAGATTTGCACTACCCAGCACCAG
CTGACCATGCACATTCGCCAGCACAACACAGACACTGGAGGAGCCGACCACTCATGCAGC
ATCTGCGGAAAGTCACTGAGCTCGGCCAGCTCCCTCGATCGCCACATGCTGGTGCACTCT
GGCGAGAGGCCTTACAAGTGCACTGTGTGTGGCCAGTCATTTACCACCAATGGGAACATG
CACAGACATATGAAGATCCATGAGAAGGACCCTAACAGTGCCACAGCCACAGCCCCTCCA
TCTCCTCTGAAACGTAGGCGATTGTCCTCCAAGAGGAAACTGAGTCACGATGCCGAGTCA
GAGAGAGAAGACCCAGCACCAGCTAAAAAGATGGTAGAAGACGGGCAGTCAGGTGACTTG
GAGAAGAAAGCTGATGAAGTCTTTCACTGCCCAGTATGTTTCAAGGAGTTTGTTTGCAAG
TATGGACTGGAGACCCACATGGAGACCCATTCAGATAACCCACTAAGATGTGACATTTGT
TGTGTCACCTTTCGAACACATCGAGGACTGCTGCGTCACAACGCGCTTGTCCACAAACAA
CTTCCCAGGGATGCAATGGGCAGACCTTTCATACAGAACAACCCTTCAATTCCTGCTGGC
TTCCACGACTTAGGATTCACGGACTTCTCCTGTAGGAAGTTTCCTCGCATTTCTCAGGCC
TGGTGCGAAACAAACCTGCGGAGGTGCATCAGCGAGCAACACCGTTTTGTCTGCGACACC
TGTGACAAGGCGTTCCCCATGCTCTGCTCACTGGCTCTGCACAAGCAGACCCATGTGGCG
GCAGACCAGGGTCAAGAAAAGCCGCAGGCCACGCCCCTGCCTGGTGACGCCCTGGACCAG
AAGGGCTTCCTGGCCTTGCTTGGCCTGCAGCACACCAAAGACGTCAGGCCTGCCCCCGCC
GAGGAGCCCCTGCCGGATGACAACCAGGCAATTCAGCTCCAGACACTCAAGTGTCAGCTA
CCTCAGGACCCCGGCTGCACCAACCTGCTGAGCCTGTCACCTTTCGAAGCTGCTTCCCTA
GGCGGTTCTCTCACAGTTCTCCCCGCGACCAAGGACAGCATAAAGCACCTGTCCCTGCAG
CCCTTCCAGAAGGGCTTCATCATCCAGCCTGACAGCAGCATTGTGGTCAAGCCCATCTCT
GGCGAGTCGGCCATCGAGCTGGCAGACATCCAGCAAATTCTGAAGATGGCAGCCTCGGCT
CCCCCTCAGATCAGTCTTCCGCCCTTCTCCAAGGCCCCTGCCGCCCCACTGCAGGCGATC
TTCAAGCACATGCCCCCTCTGAAGCCAAAGCCCCTGGTCACACCACGGACGGTGGTGGCC
ACCTCCACGCCCCCGCCTCTCATCAACGCCCAGCAGGCTTCCCCGGGCTGTATCAGCCCC
AGCCTGCCGCCACCGCCCCTGAAGCTCCTCAAAGGCTCAGTGGAGGCGGCCTCCAACGCC
CACCTGCTGCAGTCCAAGTCCGGGACCCAGCCCCACGCGGCCACGCGGCTCTCCCTGCAG
CAGCCGCGGGCGGAGCTGCCGGGCCAGCCTGAGATGAAGACGCAGCTGGAGCAGGACAGC
ATCATCGAGGCCCTGCTGCCGCTGAGCATGGAGGCCAAGATCAAGCAGGAGATCACAGAG
GGGGAACTCAAGGCCTTCATGACAGCGCCCGGCGGCAAGAAGACGCCCGCCATGCGCAAG
GTGCTCTACCCCTGCCGCTTCTGCAACCAGGTGTTTGCCTTCTCGGGGGTCTTGCGTGCC
CACGTGCGCTCCCACCTGGGCATCTCGCCATACCAGTGCAACATCTGCGACTACATCGCC
GCCGACAAGGCCGCGCTCATCCGCCACCTGCGCACGCACAGTGGGGAGCGGCCCTACATT
TGCAAGATCTGCCACTACCCCTTCACTGTCAAAGCCAACTGCGAGCGGCACCTGCGCAAG
AAGCACCTCAAGGCCACCCGCAAGGATATCGAGAAGAACATCGAGTATGTGAGTAGCAGC
GCGGCCGAGCTGGTGGACGCCTTCTGCGCCCCGGACACCGTGTGCCGGCTGTGCGGCGAG
GACCTCAAGCACTATCGTGCCCTGCGCATCCACATGCGCACGCACTGCGGCCGCGGCCTG
GGCGGGGGCCACAAGGGCCGCAAGCCCTTCGAGTGCAAGGAGTGCAGCGCCGCGTTCGCG
GCCAAGCGCAACTGCATCCACCACATCCTCAAGCAGCACCTGCACGTGCCCGAGCAGGAC
ATCGAGAGCTACGTGCTGGCCGCCGACGGCCTGGGCCCCGCAGAGGCGCCGGCCGCTGAG
GCGTCGGGGCGCGGGGAGGACAGTGGCTGCGCTGCCCTTGGTGACTGCAAGCCCCTCACT
GCCTTCCTGGAACCCCAGAACGGCTTTCTTCACAGGGGCCCCACCCAGCCTCCACCTCCC
CATGTCTCGATCAAGTTGGAGCCCGCCAGTAGCTTTGCGGTGGACTTCAATGAGCCCCTG
GACTTCTCGCAGAAGGGCCTGGCCCTGGTCCAAGTGAAGCAGGAAAACATCTCCTTTCTG
AGCCCTTCTTCCCTGGTCCCCTATGACTGCTCCATGGAGCCCATCGACCTGTCCATCCCC
AAGAACTTCAGGAAAGGGGACAAGGATTTGGCCACTCCCAGCGAAGCCAAGAAGCCTGAG
GAGGAGGCGGGGAGCAGCGAGCAGCCCTCTCCCTGCCCAGCACCCGGCCCTTCTCTTCCT
GTAACTTTGGGGCCCAGCGGAATCCTGGAAAGCCCCATGGCCCCTGCTCCGGCGGCCACC
CCGGAACCCCCAGCACAGCCCCTGCAGGGCCCTGTTCAGCTGGCGGTCCCAATCTACTCC
TCAGCCCTGGTCAGCAGCCCTCCACTCGTGGGCAGCTCAGCCCTCCTGAGTGGCACAGCC
TTGCTGCGTCCACTGCGGCCCAAGCCCCCGCTGCTTTTGCCAAAGCCCCCCGTGACAGAA
GAGCTGCCCCCGCTGGCCTCCATTGCCCAGATCATCTCATCTGTATCCTCGGCCCCCACC
CTGCTGAAAACCAAGGTGGCGGACCCAGGGCCCGCAAGCACTGGCAGTAACACCACGGCT
TCAGACAGCTTAGGAGGTTCTGTCCCCAAAGCCGCCACCACCGCCACCCCCGCTGCCACC
ACCAGCCCAAAAGAGTCTAGTGAGCCTCCCGCTCCAGCCAGCAGCCCAGAGGCTGCCTCT
CCCACCGAGCAGGGCCCAGCGGGCACGTCGAAGAAGAGGGGCCGGAAAAGGGGGATGAGG
AGCCGACCCCGCGCCAACAGCGGCGGGGTGGACCTGGACTCCAGCGGGGAGTTTGCCAGC
ATCGAGAAGATGCTGGCCACCACAGACACCAACAAGTTCAGTCCGTTTCTGCAGACAGCG
GAGGACAACACTCAGGATGAGGTGGCCGGAGCCCCTGCCGACCACCATGGGCCCAGTGAT
GAAGAGCAGGGCAGTCCCCCAGAAGACAAGCTGCTGAGGGCCAAGCGGAACTCGTACACC
AACTGCCTGCAGAAGATCACCTGTCCCCACTGTCCCCGGGTTTTCCCTTGGGCCAGCTCC
CTACAGAGGCACATGCTCACACACACTGACAGTCAGTCGGATGCGGAGACTGCAGCCGCC
GCGGGCGAAGTGCTAGACCTCACCTCACGGGACAGAGAGCAGCCGTCGGAGGGCGCCACT
GAGCTCCGCCAGGTCGCAGGGGATGCGCCTGTGGAGCAGGCCACGGCGGAAACGGCCTCG
CCGGTGCACCGGGAAGAGCACGGGCGTGGGGAGAGCCATGAGCCGGAGGAGGAGCATGGC
ACTGAGGAGAGCACTGGGGACGCCGACGGCGCGGAAGAGGACGCGTCGAGCAACCAGAGC
CTGGACCTGGACTTCGCCACCAAGCTCATGGACTTCAAGCTGGCGGAGGGCGACGGCGAG
GCAGGCGCCGGGGGCGCGGCCTCGCAGGAGCAGAAGCTCGCCTGCGACACCTGTGGGAAG
AGCTTCAAGTTCCTGGGCACCCTGAGCCGCCACCGGAAGGCGCACGGCCGCCAGGAGCCC
AAGGACGAGAAGGGAGATGGCGCCAGCACTGCAGAGGAGGGGCCCCAGCCCGCCCCTGAA
CAGGAGGAGAAGCCCCCCGAGACCCCGGCAGAGGTGGTGGAGTCGGCCCCGGGTGCCGGG
GAGGCCCCGGCGGAAAAGCTCGCGGAGGAGACGGAGGGCCCCTCCGACGGGGAGAGCGCG
GCCGAGAAAAGGTCCTCAGAGAAGAGCGACGATGACAAGAAACCAAAGACAGACTCCCCC
AAAAGCGTGGCCAGCAAGGCAGACAAGAGGAAGAAGGTCTGCAGCGTGTGCAACAAGCGG
TTCTGGTCGCTGCAGGACCTGACCCGGCACATGCGCTCCCACACAGGGGAAAGGCCATAC
AAATGTCAGACCTGCGAGCGAACCTTCACCTTGAAGCACAGCCTGGTTCGCCACCAGCGG
ATCCACCAGAAAGCCAGGCATGCCAAACACCACGGGAAGGACAGCGACAAGGAAGAGCGG
GGTGAGGAGGACAGCGAGAATGAGTCCACCCACAGCGGCAACAACGCCGTCTCAGAGAAC
GAGGCTGAGCTGGCTCCCAATGCCAGCAACCACATGGCTGTCACCCGGAGCCGGAAGGAG
GGCTTGGCCAGTGCCACCAAGGACTGCAGCCACAGGGAGGAGAAGGTCACGGCAGGGTGG
CCGTCTGAGCCTGGCCAGGGTGACCTTAACCCAGAGAGCCCGGCGGCCCTGGGGCAGGAC
CTGCTGGAGCCGCGCAGCAAGAGGCCTGCCCACCCAATCCTGGCCACAGCTGATGGCGCC
TCCCAGCTCGTGGGGATGGAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1687 |
| Molecular Weight
| 181418.4 |
| Theoretical pI
| 6.98 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ras-responsive element-binding protein 1
MTSSSPAGLEGSDLSSINTMMSAVMSVGKVTENGGSPQGIKSPSKPPGPNRIGRRNQETK
EEKSSYNCPLCEKICTTQHQLTMHIRQHNTDTGGADHSCSICGKSLSSASSLDRHMLVHS
GERPYKCTVCGQSFTTNGNMHRHMKIHEKDPNSATATAPPSPLKRRRLSSKRKLSHDAES
EREDPAPAKKMVEDGQSGDLEKKADEVFHCPVCFKEFVCKYGLETHMETHSDNPLRCDIC
CVTFRTHRGLLRHNALVHKQLPRDAMGRPFIQNNPSIPAGFHDLGFTDFSCRKFPRISQA
WCETNLRRCISEQHRFVCDTCDKAFPMLCSLALHKQTHVAADQGQEKPQATPLPGDALDQ
KGFLALLGLQHTKDVRPAPAEEPLPDDNQAIQLQTLKCQLPQDPGCTNLLSLSPFEAASL
GGSLTVLPATKDSIKHLSLQPFQKGFIIQPDSSIVVKPISGESAIELADIQQILKMAASA
PPQISLPPFSKAPAAPLQAIFKHMPPLKPKPLVTPRTVVATSTPPPLINAQQASPGCISP
SLPPPPLKLLKGSVEAASNAHLLQSKSGTQPHAATRLSLQQPRAELPGQPEMKTQLEQDS
IIEALLPLSMEAKIKQEITEGELKAFMTAPGGKKTPAMRKVLYPCRFCNQVFAFSGVLRA
HVRSHLGISPYQCNICDYIAADKAALIRHLRTHSGERPYICKICHYPFTVKANCERHLRK
KHLKATRKDIEKNIEYVSSSAAELVDAFCAPDTVCRLCGEDLKHYRALRIHMRTHCGRGL
GGGHKGRKPFECKECSAAFAAKRNCIHHILKQHLHVPEQDIESYVLAADGLGPAEAPAAE
ASGRGEDSGCAALGDCKPLTAFLEPQNGFLHRGPTQPPPPHVSIKLEPASSFAVDFNEPL
DFSQKGLALVQVKQENISFLSPSSLVPYDCSMEPIDLSIPKNFRKGDKDLATPSEAKKPE
EEAGSSEQPSPCPAPGPSLPVTLGPSGILESPMAPAPAATPEPPAQPLQGPVQLAVPIYS
SALVSSPPLVGSSALLSGTALLRPLRPKPPLLLPKPPVTEELPPLASIAQIISSVSSAPT
LLKTKVADPGPASTGSNTTASDSLGGSVPKAATTATPAATTSPKESSEPPAPASSPEAAS
PTEQGPAGTSKKRGRKRGMRSRPRANSGGVDLDSSGEFASIEKMLATTDTNKFSPFLQTA
EDNTQDEVAGAPADHHGPSDEEQGSPPEDKLLRAKRNSYTNCLQKITCPHCPRVFPWASS
LQRHMLTHTDSQSDAETAAAAGEVLDLTSRDREQPSEGATELRQVAGDAPVEQATAETAS
PVHREEHGRGESHEPEEEHGTEESTGDADGAEEDASSNQSLDLDFATKLMDFKLAEGDGE
AGAGGAASQEQKLACDTCGKSFKFLGTLSRHRKAHGRQEPKDEKGDGASTAEEGPQPAPE
QEEKPPETPAEVVESAPGAGEAPAEKLAEETEGPSDGESAAEKRSSEKSDDDKKPKTDSP
KSVASKADKRKKVCSVCNKRFWSLQDLTRHMRSHTGERPYKCQTCERTFTLKHSLVRHQR
IHQKARHAKHHGKDSDKEERGEEDSENESTHSGNNAVSENEAELAPNASNHMAVTRSRKE
GLASATKDCSHREEKVTAGWPSEPGQGDLNPESPAALGQDLLEPRSKRPAHPILATADGA
SQLVGME
|
| External Links |
|---|
| GenBank ID Protein
| 51173735 |
| UniProtKB/Swiss-Prot ID
| Q92766 |
| UniProtKB/Swiss-Prot Entry Name
| RREB1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001003698.3 |
| GeneCard ID
| RREB1 |
| GenAtlas ID
| RREB1 |
| HGNC ID
| HGNC:10449 |
| References |
|---|
| General References
| Not Available |