| Identification |
|---|
| HMDB Protein ID
| CDBP04890 |
| Secondary Accession Numbers
| Not Available |
| Name
| Interphotoreceptor matrix proteoglycan 2 |
| Description
| Not Available |
| Synonyms
|
- IPM 200
- Interphotoreceptor matrix proteoglycan of 200 kDa
- Sialoprotein associated with cones and rods proteoglycan
- Spacrcan
|
| Gene Name
| IMPG2 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in extracellular matrix structural constituent |
| Specific Function
| Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light- sensitive photoreceptor outer segment. Binds heparin |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3q12.2-q12.3 |
| SNPs
| IMPG2 |
| Gene Sequence
|
>3726 bp
ATGATTATGTTTCCTCTTTTTGGGAAGATTTCTCTGGGTATTTTGATATTTGTCCTGATA
GAAGGAGACTTTCCATCATTAACAGCACAAACCTACTTATCTATAGAGGAGATCCAAGAA
CCCAAGAGTGCAGTTTCTTTTCTCCTGCCTGAAGAATCAACAGACCTTTCTCTAGCTACC
AAAAAGAAACAGCCTCTGGACCGCAGAGAAACTGAAAGACAGTGGTTAATCAGAAGGCGG
AGATCTATTCTGTTTCCTAATGGAGTGAAAATCTGCCCAGATGAAAGTGTTGCAGAGGCT
GTGGCAAATCATGTGAAGTATTTTAAAGTCCGAGTGTGTCAGGAAGCTGTCTGGGAAGCC
TTCAGGACTTTTTGGGATCGACTTCCTGGGCGTGAGGAATATCATTACTGGATGAATTTG
TGTGAGGATGGAGTCACAAGTATATTTGAAATGGGCACAAATTTTAGTGAATCTGTGGAA
CATAGAAGCTTAATCATGAAGAAACTGACTTATGCAAAGGAAACTGTAAGCAGCTCTGAA
CTGTCTTCTCCAGTTCCTGTTGGTGATACTTCAACATTGGGAGACACTACTCTCAGTGTT
CCACATCCAGAGGTGGACGCCTATGAAGGTGCCTCAGAGAGCAGCTTGGAAAGGCCAGAG
GAGAGTATTAGCAATGAAATTGAGAATGTGATAGAAGAAGCCACAAAACCAGCAGGTGAA
CAGATTGCAGAATTCAGTATCCACCTTTTGGGGAAGCAGTACAGGGAAGAACTACAGGAT
TCCTCCAGCTTTCACCACCAGCACCTTGAAGAAGAATTTATTTCAGAGGTTGAAAATGCA
TTTACTGGGTTACCAGGCTACAAGGAAATTCGTGTACTTGAATTTAGGTCCCCCAAGGAA
AATGACAGTGGCGTAGATGTTTACTATGCAGTTACCTTCAATGGTGAGGCCATCAGCAAT
ACCACCTGGGACCTCATTAGCCTTCACTCCAACAAGGTGGAAAACCATGGCCTTGTGGAA
CTGGATGATAAACCCACTGTTGTTTATACAATCAGTAACTTCAGAGATTATATTGCTGAG
ACATTGCAGCAGAATTTTTTGCTGGGGAACTCTTCCTTGAATCCAGATCCTGATTCCCTG
CAGCTTATCAATGTGAGAGGAGTTTTGCGTCACCAAACTGAAGATCTAGTTTGGAACACC
CAAAGTTCAAGTCTTCAGGCAACGCCGTCATCTATTCTGGATAATACCTTTCAAGCTGCA
TGGCCCTCAGCAGATGAATCCATCACCAGCAGTATTCCACCACTTGATTTCAGCTCTGGT
CCTCCCTCAGCCACTGGCAGGGAACTCTGGTCAGAAAGTCCTTTGGGTGATTTAGTGTCT
ACACACAAATTAGCCTTTCCCTCGAAGATGGGCCTCAGCTCTTCCCCAGAGGTTTTAGAG
GTTAGCAGCTTGACTCTTCATTCTGTCACCCCGGCAGTGCTTCAGACTGGCTTGCCTGTG
GCTTCTGAGGAAAGGACTTCTGGATCTCACTTGGTAGAAGATGGATTAGCCAATGTTGAA
GAGTCAGAAGATTTTCTTTCTATTGATTCATTGCCTTCAAGTTCATTCACTCAACCTGTG
CCAAAAGAAACAATACCATCCATGGAAGACTCTGATGTGTCCTTAACATCTTCACCATAT
CTGACCTCTTCTATACCTTTTGGCTTGGACTCCTTGACCTCCAAAGTCAAAGACCAATTA
AAAGTGAGCCCTTTCCTGCCAGATGCATCCATGGAAAAAGAGTTAATATTTGACGGTGGT
TTAGGTTCAGGGTCTGGGCAAAAGGTAGATCTGATTACTTGGCCATGGAGTGAGACTTCA
TCAGAGAAGAGCGCTGAACCACTGTCCAAGCCGTGGCTTGAAGATGATGATTCACTTTTG
CCAGCTGAGATTGAAGACAAGAAACTAGTTTTAGTTGACAAAATGGATTCCACAGACCAA
ATTAGTAAGCACTCAAAATATGAACATGATGACAGATCCACACACTTTCCAGAGGAAGAG
CCTCTTAGTGGGCCTGCTGTGCCCATCTTCGCAGATACTGCAGCTGAATCTGCGTCTCTA
ACCCTCCCCAAGCACATATCAGAAGTACCTGGTGTTGATGATTACTCAGTTACCAAAGCA
CCTCTTATACTGACATCTGTAGCAATCTCTGCCTCTACTGATAAATCAGATCAGGCAGAT
GCCATCCTAAGGGAGGATATGGAACAAATTACTGAGTCATCCAACTATGAATGGTTTGAC
AGTGAGGTTTCAATGGTAAAGCCAGATATGCAAACTTTGTGGACTATATTGCCAGAATCA
GAGAGAGTTTGGACAAGAACTTCTTCCCTAGAGAAATTGTCCAGAGACATATTGGCAAGT
ACACCACAGAGTGCTGACAGGCTCTGGTTATCTGTGACACAGTCTACCAAATTGCCTCCA
ACCACAATCTCCACCCTGCTAGAGGATGAAGTAATTATGGGTGTACAGGATATTTCGTTA
GAACTGGACCGGATAGGCACAGATTACTATCAGCCTGAGCAAGTCCAAGAGCAAAATGGC
AAGGTTGGTAGTTATGTGGAAATGTCAACAAGTGTTCACTCCACAGAGATGGTTAGTGTG
GCTTGGCCCACAGAAGGAGGAGATGACTTGAGTTATACCCAGACTTCAGGAGCTTTGGTG
GTTTTCTTCAGCCTCCGAGTGACTAACATGATGTTTTCAGAAGATCTGTTTAATAAAAAC
TCCTTGGAGTATAAAGCCCTGGAGCAAAGATTCTTAGAATTGCTGGTTCCCTATCTCCAG
TCAAATCTCACGGGGTTCCAGAACTTAGAAATCCTCAACTTCAGAAATGGCAGCATTGTG
GTGAACAGTCGAATGAAGTTTGCCAATTCTGTCCCTCCTAACGTCAACAATGCGGTGTAC
ATGATTCTGGAAGACTTTTGTACCACTGCCTACAATACCATGAACTTGGCTATTGATAAA
TACTCTCTTGATGTGGAATCAGGTGATGAAGCCAACCCTTGCAAGTTTCAGGCCTGTAAT
GAATTTTCAGAGTGTCTGGTCAACCCCTGGAGTGGAGAAGCAAAGTGCAGATGCTTCCCT
GGATACCTGAGTGTGGAAGAACGGCCCTGTCAGAGTCTCTGTGACCTACAGCCTGACTTC
TGCTTGAATGATGGAAAGTGTGACATTATGCCTGGGCACGGGGCCATTTGTAGGTGCCGG
GTGGGTGAGAACTGGTGGTACCGAGGCAAGCACTGTGAGGAATTTGTGTCTGAGCCCGTG
ATCATAGGCATCACTATTGCCTCCGTGGTTGGACTTCTTGTCATCTTTTCTGCTATCATC
TACTTCTTCATCAGGACTCTTCAAGCACACCATGACAGGAGTGAAAGAGAGAGTCCCTTC
AGTGGCTCCAGCAGGCAGCCTGACAGCCTCTCATCTATTGAGAATGCTGTGAAGTACAAC
CCCGTGTATGAAAGTCACAGGGCTGGATGTGAGAAGTATGAGGGACCCTATCCTCAGCAT
CCCTTCTACAGCTCTGCTAGCGGAGACGTGATTGGTGGGCTGAGCAGAGAAGAAATCAGA
CAGATGTATGAGAGCAGTGAGCTTTCCAGAGAGGAAATTCAAGAGAGAATGAGAGTTTTG
GAACTGTATGCCAATGATCCTGAGTTTGCAGCTTTTGTGAGAGAGCAACAAGTGGAAGAG
GTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1241 |
| Molecular Weight
| 138619.4 |
| Theoretical pI
| 4.24 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Interphotoreceptor matrix proteoglycan 2
MIMFPLFGKISLGILIFVLIEGDFPSLTAQTYLSIEEIQEPKSAVSFLLPEESTDLSLAT
KKKQPLDRRETERQWLIRRRRSILFPNGVKICPDESVAEAVANHVKYFKVRVCQEAVWEA
FRTFWDRLPGREEYHYWMNLCEDGVTSIFEMGTNFSESVEHRSLIMKKLTYAKETVSSSE
LSSPVPVGDTSTLGDTTLSVPHPEVDAYEGASESSLERPEESISNEIENVIEEATKPAGE
QIAEFSIHLLGKQYREELQDSSSFHHQHLEEEFISEVENAFTGLPGYKEIRVLEFRSPKE
NDSGVDVYYAVTFNGEAISNTTWDLISLHSNKVENHGLVELDDKPTVVYTISNFRDYIAE
TLQQNFLLGNSSLNPDPDSLQLINVRGVLRHQTEDLVWNTQSSSLQATPSSILDNTFQAA
WPSADESITSSIPPLDFSSGPPSATGRELWSESPLGDLVSTHKLAFPSKMGLSSSPEVLE
VSSLTLHSVTPAVLQTGLPVASEERTSGSHLVEDGLANVEESEDFLSIDSLPSSSFTQPV
PKETIPSMEDSDVSLTSSPYLTSSIPFGLDSLTSKVKDQLKVSPFLPDASMEKELIFDGG
LGSGSGQKVDLITWPWSETSSEKSAEPLSKPWLEDDDSLLPAEIEDKKLVLVDKMDSTDQ
ISKHSKYEHDDRSTHFPEEEPLSGPAVPIFADTAAESASLTLPKHISEVPGVDDYSVTKA
PLILTSVAISASTDKSDQADAILREDMEQITESSNYEWFDSEVSMVKPDMQTLWTILPES
ERVWTRTSSLEKLSRDILASTPQSADRLWLSVTQSTKLPPTTISTLLEDEVIMGVQDISL
ELDRIGTDYYQPEQVQEQNGKVGSYVEMSTSVHSTEMVSVAWPTEGGDDLSYTQTSGALV
VFFSLRVTNMMFSEDLFNKNSLEYKALEQRFLELLVPYLQSNLTGFQNLEILNFRNGSIV
VNSRMKFANSVPPNVNNAVYMILEDFCTTAYNTMNLAIDKYSLDVESGDEANPCKFQACN
EFSECLVNPWSGEAKCRCFPGYLSVEERPCQSLCDLQPDFCLNDGKCDIMPGHGAICRCR
VGENWWYRGKHCEEFVSEPVIIGITIASVVGLLVIFSAIIYFFIRTLQAHHDRSERESPF
SGSSRQPDSLSSIENAVKYNPVYESHRAGCEKYEGPYPQHPFYSSASGDVIGGLSREEIR
QMYESSELSREEIQERMRVLELYANDPEFAAFVREQQVEEV
|
| External Links |
|---|
| GenBank ID Protein
| 57242793 |
| UniProtKB/Swiss-Prot ID
| Q9BZV3 |
| UniProtKB/Swiss-Prot Entry Name
| IMPG2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_016247.2 |
| GeneCard ID
| IMPG2 |
| GenAtlas ID
| IMPG2 |
| HGNC ID
| HGNC:18362 |
| References |
|---|
| General References
| Not Available |