| Identification |
|---|
| HMDB Protein ID
| CDBP04877 |
| Secondary Accession Numbers
| Not Available |
| Name
| Type-1 angiotensin II receptor-associated protein |
| Description
| Not Available |
| Synonyms
|
- AT1 receptor-associated protein
|
| Gene Name
| AGTRAP |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Golgi apparatus membrane
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
- Multi-pass membrane protein
- Multi-pass membrane protein
- Cytoplasmic vesicle membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p36.22 |
| SNPs
| AGTRAP |
| Gene Sequence
|
>480 bp
ATGGAGCTGCCTGCTGTGAACCTGAAGGTGATTCTCCTAGGTCACTGGCTGCTGACAACC
TGGGGCTGCATTGTATTCTCAGGCTCCTATGCCTGGGCCAACTTCACCATCCTGGCCTTG
GGCGTGTGGGCTGTGGCTCAGCGGGACTCCATCGACGCCATAAGCATGTTTCTGGGTGGC
TTGCTGGCCACAATCTTCCTGGACATCGTGCACATCAGCATCTTCTACCCGCGGGTCAGC
CTCACGGACACGGGCCGCTTTGGCGTGGGCATGGCCATCCTCAGCTTGCTGCTCAAGCCG
CTCTCCTGCTGCTTCGTCTACCACATGTACCGGGAGCGCGGGGGTGAGCTCCTGGTCCAC
ACTGGTTTCCTTGGGTCTTCTCAGGACCGTAGTGCCTACCAGACGATTGACTCAGCAGAG
GCGCCCGCAGATCCCTTTGCAGTCCCAGAGGGCAGGAGTCAAGATGCCCGAAGGTACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 159 |
| Molecular Weight
| 17419.0 |
| Theoretical pI
| 6.07 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["24-44", "56-76", "87-107"]
|
| Protein Sequence
|
>Type-1 angiotensin II receptor-associated protein
MELPAVNLKVILLGHWLLTTWGCIVFSGSYAWANFTILALGVWAVAQRDSIDAISMFLGG
LLATIFLDIVHISIFYPRVSLTDTGRFGVGMAILSLLLKPLSCCFVYHMYRERGGELLVH
TGFLGSSQDRSAYQTIDSAEAPADPFAVPEGRSQDARGY
|
| External Links |
|---|
| GenBank ID Protein
| 9621816 |
| UniProtKB/Swiss-Prot ID
| Q6RW13 |
| UniProtKB/Swiss-Prot Entry Name
| ATRAP_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF165187 |
| GeneCard ID
| AGTRAP |
| GenAtlas ID
| AGTRAP |
| HGNC ID
| HGNC:13539 |
| References |
|---|
| General References
| Not Available |