| Identification |
|---|
| HMDB Protein ID
| CDBP04875 |
| Secondary Accession Numbers
| Not Available |
| Name
| Proton-coupled amino acid transporter 2 |
| Description
| Not Available |
| Synonyms
|
- Proton/amino acid transporter 2
- Solute carrier family 36 member 2
- Tramdorin-1
|
| Gene Name
| SLC36A2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids amino acids such as glycine, alanine and proline. Inhibited by sarcosine |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q33.1 |
| SNPs
| SLC36A2 |
| Gene Sequence
|
>1452 bp
ATGTCTGTGACAAAAAGTACTGAGGGTCCCCAGGGAGCCGTTGCCATCAAATTGGACCTT
ATGTCGCCTCCTGAAAGTGCCAAGAAGTTGGAGAACAAGGACTCTACATTCTTGGATGAA
AGTCCTTCAGAGTCAGCAGGCTTGAAGAAGACCAAGGGCATAACAGTGTTCCAGGCCTTG
ATTCACCTGGTGAAAGGCAACATGGGCACAGGGATCCTGGGACTACCCCTCGCTGTGAAG
AACGCGGGCATCCTGATGGGCCCACTCAGTCTGCTGGTGATGGGCTTCATTGCCTGCCAC
TGTATGCACATCCTGGTCAAGTGTGCCCAGCGCTTCTGTAAGAGGCTTAACAAGCCCTTT
ATGGACTATGGGGACACGGTGATGCATGGACTAGAAGCCAACCCCAACGCCTGGCTCCAG
AATCACGCTCACTGGGGAAGGCATATCGTGAGCTTCTTCCTTATTATCACCCAACTTGGC
TTCTGCTGTGTGTACATTGTGTTTTTGGCTGATAATTTAAAACAGGTAGTGGAAGCTGTT
AATAGCACAACCAACAACTGCTATTCCAATGAGACGGTGATTCTGACCCCCACCATGGAC
TCGCGACTCTACATGCTCTCCTTCCTGCCCTTCCTGGTGCTGCTGGTCCTCATCCGGAAC
CTCAGGATCTTGACCATCTTCTCCATGCTGGCCAACATCAGCATGCTGGTCAGCTTGGTC
ATCATCATACAGTACATTACCCAGGAAATCCCAGACCCCAGCCGGTTGCCACTGGTAGCA
AGCTGGAAGACCTACCCTCTCTTCTTCGGAACAGCCATTTTTTCTTTTGAAAGCATTGGT
GTGGTTCTGCCTCTGGAAAACAAGATGAAGAATGCCCGCCACTTCCCAGCCATCCTGTCT
TTGGGAATGTCCATCGTCACTTCCCTATACATTGGCATGGCGGCTCTGGGCTACCTGCGG
TTTGGAGATGACATCAAGGCCAGCATAAGCCTTAACCTGCCTAACTGCTGGCTGTACCAG
TCTGTCAAGCTTCTCTACATTGCCGGCATCCTGTGCACCTATGCCCTGCAGTTCTACGTC
CCTGCAGAAATCATCATCCCCTTTGCCATCTCCCGGGTGTCAACACGCTGGGCACTGCCT
CTGGATCTGTCCATTCGCCTCGTCATGGTCTGCCTGACATGCCTCCTGGCCATCCTCATC
CCCCGCCTGGACCTGGTCATCTCCCTGATGGGCTCCGTGAGTGGCACCGCCCTGGCCCTC
ATCATCCCACCGCTCCTGGAGGTCCCCACGTTCTACTCAGAGGGCATGAGCCCCCTCACC
ATCTTCAAGGACGCCCTGATCAGCATCCTGGGCTTCGTGGGCTTTGTGGTGGGGACCTAC
CAGGCCCTGGACGAGCTGCTCAAGTCAGAAGACTCTCACCCCTTTTCCAACTCCACCACT
TTTGTTCGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 483 |
| Molecular Weight
| 53215.7 |
| Theoretical pI
| 8.2 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["59-79", "82-102", "149-169", "198-218", "223-243", "265-285", "297-317", "350-370", "380-400", "405-425", "438-458"]
|
| Protein Sequence
|
>Proton-coupled amino acid transporter 2
MSVTKSTEGPQGAVAIKLDLMSPPESAKKLENKDSTFLDESPSESAGLKKTKGITVFQAL
IHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGFIACHCMHILVKCAQRFCKRLNKPF
MDYGDTVMHGLEANPNAWLQNHAHWGRHIVSFFLIITQLGFCCVYIVFLADNLKQVVEAV
NSTTNNCYSNETVILTPTMDSRLYMLSFLPFLVLLVLIRNLRILTIFSMLANISMLVSLV
IIIQYITQEIPDPSRLPLVASWKTYPLFFGTAIFSFESIGVVLPLENKMKNARHFPAILS
LGMSIVTSLYIGMAALGYLRFGDDIKASISLNLPNCWLYQSVKLLYIAGILCTYALQFYV
PAEIIIPFAISRVSTRWALPLDLSIRLVMVCLTCLLAILIPRLDLVISLVGSVSGTALAL
IIPPLLEVTTFYSEGMSPLTIFKDALISILGFVGFVVGTYQALDELLKSEDSHPFSNSTT
FVR
|
| External Links |
|---|
| GenBank ID Protein
| 34527813 |
| UniProtKB/Swiss-Prot ID
| Q495M3 |
| UniProtKB/Swiss-Prot Entry Name
| S36A2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK122630 |
| GeneCard ID
| SLC36A2 |
| GenAtlas ID
| SLC36A2 |
| HGNC ID
| HGNC:18762 |
| References |
|---|
| General References
| Not Available |