Cannabis Compound Database: Showing Protein Potassium voltage-gated channel subfamily A member 4 (CDBP04849)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP04849

Secondary Accession Numbers

Not Available

Name

Potassium voltage-gated channel subfamily A member 4

Description

Not Available

Synonyms

HPCN2
Voltage-gated K(+) channel HuKII
Voltage-gated potassium channel HBK4
Voltage-gated potassium channel HK1
Voltage-gated potassium channel subunit Kv1.4

Gene Name

KCNA4

Protein Type

Enzyme

Biological Properties

General Function

Involved in protein binding

Specific Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient

GO Classification

Component
membrane
cell part
membrane part
ion channel complex
cation channel complex
potassium channel complex
voltage-gated potassium channel complex
macromolecular complex
intrinsic to membrane
protein complex
integral to membrane
Function
protein binding
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
alkali metal ion binding
potassium ion binding
ion channel activity
cation channel activity
potassium channel activity
voltage-gated potassium channel activity
ion binding
cation binding
metal ion binding
binding
Process
ion transport
cation transport
establishment of localization
transport
transmembrane transport
monovalent inorganic cation transport
potassium ion transport

Cellular Location

Membrane
Multi-pass membrane protein

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

11p14

SNPs

KCNA4

Gene Sequence

>1962 bp
ATGGAGGTTGCAATGGTGAGTGCGGAGAGCTCAGGGTGCAACAGTCACATGCCTTATGGT
TATGCTGCCCAGGCCCGGGCCCGGGAGCGGGAGAGGCTTGCTCACTCCAGGCGAGCTGCA
GCACGTGCTGTTGCAGCGGCCACAGCTGCTGTCGAAGGTAGCGGGGGTTCTGGTGGGGGC
TCCCACCACCACCACCAGTCACGCGGGGCCTGTACCTCCCATGACCCTCAGAGCAGCCGG
GGTAGTCGGGAGGAGGAGGCGACACGGTCTGAGAAGAAGAAAGCCCACTACCGGCAGAGC
AGCTTCCCTCATTGCTCTGACCTGATGCCCAGTGGCTCTGAGGAGAAGATCCTGAGGGAG
CTGAGTGAGGAGGAGGAAGATGAGGAGGAGGAGGAAGAGGAGGAAGAGGAGGGAAGGTTT
TACTATAGTGAAGATGACCATGGTGATGAGTGTTCCTACACGGATCTGCTGCCTCAGGAT
GAGGGCGGTGGCGGCTACAGTTCAGTCCGCTACAGTGACTGTTGTGAACGTGTGGTGATA
AATGTGTCAGGCCTACGCTTTGAGACCCAAATGAAAACTCTGGCCCAGTTTCCAGAGACT
TTGTTGGGAGACCCTGAAAAGAGGACTCAGTACTTTGACCCTTTGCGCAATGAGTATTTT
TTTGACAGGAACCGCCCCAGCTTTGATGCCATCTTGTATTATTATCAATCAGGAGGCCGC
CTGAAGAGGCCAGTCAATGTCCCCTTTGATATCTTCACTGAGGAGGTGAAGTTCTATCAG
TTGGGGGAGGAGGCCCTGTTGAAGTTTCGGGAGGACGAGGGCTTTGTGAGAGAAGAGGAA
GACAGGGCCCTCCCCGAGAATGAATTTAAAAAGCAGATTTGGCTCCTCTTTGAATATCCA
GAGAGCTCCGATCCTGCAAGGGGCATAGCCATTGTGTCCGTCCTGGTCATCTTAATCTCC
ATTGTCATCTTTTGCCTGGAAACCTTGCCTGAGTTTAGGGACGACAGGGATCTCGTCATG
GCACTGAGTGCTGGCGGGCATGGTGGGTTGTTGAATGATACTTCAGCACCCCATCTGGAG
AACTCAGGGCACACAATATTCAATGACCCCTTCTTCATCGTGGAAACAGTCTGTATTGTA
TGGTTTTCCTTTGAGTTTGTGGTTCGCTGCTTTGCTTGTCCCAGCCAAGCACTCTTCTTC
AAAAACATCATGAACATCATTGACATTGTCTCCATTTTGCCTTACTTCATCACACTGGGC
ACTGACCTGGCCCAGCAACAGGGGGGTGGCAATGGTCAGCAGCAGCAGGCCATGTCCTTT
GCCATCCTCAGAATCATTCGTCTGGTCCGAGTATTCCGGATCTTCAAACTCTCCAGGCAC
TCCAAAGGCCTGCAGATCCTGGGCCACACCCTCAGAGCCAGCATGCGGGAACTGGGCCTT
CTGATCTTCTTCCTCTTCATTGGGGTCATCCTCTTTTCTAGTGCTGTGTATTTTGCAGAG
GCGGATGAACCTACTACCCATTTCCAAAGCATCCCAGATGCATTTTGGTGGGCTGTGGTG
ACCATGACAACTGTGGGCTATGGGGACATGAAGCCCATCACTGTAGGGGGCAAGATTGTC
GGGGTCCTGTGTGCCATTGCGGGTGTCTTAACCATTGCTTTGCCAGTGCCAGTGATTGTC
TCTAACTTTAACTATTTCTACCACAGAGAGACTGAAAATGAGGAACAGACACAGCTAACG
CAGAATGCAGTCAGTTGTCCATACCTCCCCTCTAATTTGCTCAAGAAATTTCGGAGCTCT
ACTTCTTCTTCCCTGGGGGACAAGTCAGAGTATCTAGAGATGGAAGAAGGAGTTAAGGAA
TCTCTGTGTGCCAAGGAGGAGAAGTGTCAGGCCAAGGGGGATGACAGTGAGACAGATAAA
AACAACTGTTCTAATGCAAAGGCTGTGGAGACTGATGTGTGA

Protein Properties

Number of Residues

653

Molecular Weight

73287.6

Theoretical pI

4.67

Pfam Domain Function

Ion_trans (PF00520 )
K_tetra (PF02214 )
K_channel_TID (PF07941 )

Signals

["None"]

Transmembrane Regions

["308-326", "371-392", "404-424", "443-461", "478-497", "539-561"]

Protein Sequence

>Potassium voltage-gated channel subfamily A member 4
MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRRAAARAVAAATAAVEGSGGSGGG
SHHHHQSRGACTSHDPQSSRGSREEEATRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRE
LSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVI
NVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGR
LKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYP
ESSDPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLE
NSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLG
TDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGL
LIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIV
GVLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSS
TSSSLGDKSEYLEMEEGVKESLCAKEEKCQAKGDDSETDKNNCSNAKAVETDV

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

P22459

UniProtKB/Swiss-Prot Entry Name

KCNA4_HUMAN

PDB IDs