| Identification |
|---|
| HMDB Protein ID
| CDBP04840 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cyclic nucleotide-gated cation channel beta-1 |
| Description
| Not Available |
| Synonyms
|
- CNG channel 4
- CNG channel beta-1
- CNG-4
- CNG4
- Cyclic nucleotide-gated cation channel 4
- Cyclic nucleotide-gated cation channel gamma
- Cyclic nucleotide-gated cation channel modulatory subunit
- Cyclic nucleotide-gated channel beta-1
- GARP
- Glutamic acid-rich protein
|
| Gene Name
| CNGB1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Signal transduction mechanisms |
| Specific Function
| Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties:it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16q13 |
| SNPs
| CNGB1 |
| Gene Sequence
|
>3756 bp
ATGTTGGGCTGGGTCCAGAGGGTGCTGCCTCAGCCCCCAGGGACCCCTCGGAAGACCAAG
ATGCAGGAGGAAGAGGAAGTGGAACCAGAGCCAGAGATGGAGGCGGAGGTGGAACCAGAA
CCGAATCCTGAGGAGGCCGAGACAGAGTCCGAGTCCATGCCCCCCGAAGAGTCATTCAAG
GAGGAGGAAGTGGCTGTGGCAGACCCAAGCCCTCAGGAGACCAAGGAGGCTGCCCTTACT
TCCACCATATCCCTCCGGGCCCAGGGCGCTGAGATTTCTGAAATGAATAGTCCCAGCCGC
AGGGTACTGACCTGGCTCATGAAGGGCGTAGAGAAGGTGATCCCGCAGCCTGTTCACAGC
ATCACGGAGGACCCGGCTCAGATCCTGGGGCATGGCAGCACTGGGGACACAGGGTGCACA
GATGAACCCAATGAGGCCCTTGAGGCCCAAGACACTAGGCCTGGGCTGCGGCTGCTTCTG
TGGCTGGAGCAGAATCTGGAAAGAGTGCTTCCTCAGCCCCCCAAATCCTCTGAGGTCTGG
AGAGATGAGCCTGCAGTTGCTACAGGTGCTGCCTCAGACCCAGCGCCTCCAGGACGCCCC
CAGGAAATGGGGCCCAAGCTGCAGGCCCGGGAGACCCCCTCCCTGCCCACACCCATCCCC
CTGCAGCCCAAGGAGGAACCCAAGGAGGCACCAGCTCCAGAGCCCCAGCCCGGCTCCCAG
GCCCAGACCTCCTCCCTGCCACCAACCAGGGACCCTGCCAGGCTGGTGGCATGGGTCCTG
CACAGGCTGGAGATGGCCTTGCCGCAGCCAGTGCTACATGGGAAAATAGGGGAACAGGAG
CCTGACTCCCCTGGGATATGTGATGTGCAGACCATCAGCATCCTTCCTGGAGGACAAGTG
GAGCCTGACCTTGTCCTAGAGGAGGTTGAACCGCCCTGGGAGGATGCCCACCAGGATGTC
AGTACCAGCCCACAGGGTACAGAGGTGGTTCCAGCTTATGAAGAAGAGAACAAAGCTGTG
GAGAAGATGCCCAGAGAGCTGTCCCGGATTGAAGAGGAGAAAGAAGATGAGGAGGAGGAA
GAGGAAGAGGAGGAGGAGGAGGAAGAGGAGGAGGTGACTGAGGTGCTGCTGGATAGCTGT
GTGGTGTCGCAGGTGGGCGTGGGCCAGAGTGAAGAAGACGGGACCCGGCCCCAGAGCACT
TCAGATCAGAAGCTGTGGGAGGAAGTTGGGGAGGAGGCCAAGAAGGAGGCTGAAGAGAAG
GCCAAGGAGGAGGCCGAGGAGGTGGCTGAAGAGGAGGCTGAAAAGGAGCCCCAGGACTGG
GCGGAGACCAAGGAGGAGCCTGAGGCTGAGGCCGAGGCTGCCAGTTCAGGAGTGCCTGCC
ACGAAACAGCACCCAGAAGTGCAGGTGGAAGATACTGATGCTGATAGCTGCCCCCTCATG
GCAGAAGAGAATCCACCCTCAACCGTGTTGCCGCCACCGTCTCCTGCCAAATCAGACACC
CTTATAGTCCCAAGCTCAGCCTCGGGGACACACAGGAAGAAGCTGCCCTCTGAGGATGAT
GAGGCTGAAGAGCTCAAGGCGTTGTCACCAGCAGAGTCCCCAGTGGTTGCCTGGTCTGAC
CCCACCACCCCGAAGGACACTGATGGCCAGGACCGTGCGGCCTCCACGGCCAGCACAAAT
AGCGCCATCATCAACGACCGGCTCCAGGAGCTGGTGAAGCTCTTCAAGGAGCGGACAGAG
AAAGTGAAGGAGAAACTCATTGACCCTGACGTCACCTCTGATGAGGAGAGCCCCAAGCCC
TCCCCAGCCAAGAAAGCCCCAGAGCCAGCTCCAGACACAAAGCCCGCTGAAGCCGAGCCA
GTGGAAGAGGAGCACTATTGCGACATGCTCTGCTGCAAGTTCAAACACCGCCCCTGGAAG
AAGTACCAGTTTCCCCAGAGCATTGACCCGCTGACCAACCTGATGTATGTCCTATGGCTG
TTCTTCGTGGTGATGGCCTGGAATTGGAACTGTTGGCTGATTCCCGTGCGCTGGGCCTTC
CCCTACCAGACCCCGGACAACATCCACCACTGGCTGCTGATGGATTACCTATGCGACCTC
ATCTACTTCCTGGACATCACCGTGTTCCAGACACGCCTGCAGTTTGTCAGAGGCGGGGAC
ATCATTACGGACAAAAAGGACATGCGAAATAACTACCTGAAGTCTCGCCGCTTCAAGATG
GACCTGCTCAGCCTCCTGCCCTTGGATTTTCTCTATTTGAAAGTCGGTGTGAACCCCCTC
CTCCGCCTGCCCCGCTGTTTAAAGTACATGGCCTTCTTCGAGTTTAACAGCCGCCTGGAA
TCCATCCTCAGCAAAGCCTACGTGTACAGGGTCATCAGGACCACAGCCTACCTTCTCTAC
AGCCTGCATTTGAATTCCTGTCTTTATTACTGGGCATCGGCCTATCAGGGCCTCGGCTCC
ACTCACTGGGTTTACGATGGCGTGGGAAACAGTTATATTCGCTGTTACTACTTTGCTGTG
AAGACCCTCATCACCATCGGGGGGCTGCCTGACCCCAAGACACTCTTTGAAATTGTCTTC
CAGCTGCTGAATTATTTCACGGGCGTCTTTGCTTTCTCTGTGATGATCGGACAGATGAGA
GATGTGGTAGGGGCCGCCACCGCCGGACAGACCTACTACCGCAGCTGCATGGACAGCACG
GTGAAGTACATGAATTTCTACAAGATCCCCAAGTCCGTGCAGAACCGCGTCAAGACCTGG
TACGAGTACACCTGGCACTCGCAAGGCATGCTGGATGAGTCAGAGCTGATGGTGCAGCTT
CCAGACAAGATGCGGCTGGACCTCGCCATCGACGTGAACTACAACATCGTTAGCAAAGTC
GCACTCTTTCAGGGCTGTGACCGGCAGATGATCTTTGACATGCTGAAGAGGCTTCGCTCT
GTTGTCTACCTGCCCAACGACTATGTGTGCAAGAAGGGGGAGATCGGCCGTGAGATGTAC
ATCATCCAGGCAGGGCAAGTGCAGGTCTTGGGCGGCCCTGATGGGAAATCTGTGCTGGTG
ACGCTGAAAGCTGGATCTGTGTTTGGAGAAATAAGCTTGCTGGCTGTTGGGGGCGGGAAC
CGGCGCACGGCCAACGTGGTGGCGCACGGGTTTACCAACCTCTTCATCCTGGATAAGAAG
GACCTGAATGAGATTTTGGTGCATTATCCTGAGTCTCAGAAGTTACTCCGGAAGAAAGCC
AGGCGCATGCTGAGAAGCAACAATAAGCCCAAGGAGGAGAAGAGCGTGCTGATCCTTCCA
CCCCGGGCGGGCACCCCAAAGCTCTTCAACGCTGCCCTCGCTATGACAGGAAAGATGGGT
GGCAAGGGGGCAAAAGGCGGCAAACTTGCTCACCTCCGGGCCCGGCTCAAAGAACTGGCC
GCGCTGGAGGCGGCTGCAAAGCAGCAAGAGTTGGTGGAACAGGCCAAGAGCTCGCAAGAC
GTCAAGGGAGAGGAAGGCTCCGCCGCCCCAGACCAGCACACGCACCCAAAGGAGGCCGCC
ACCGACCCACCCGCGCCCCGGACGCCCCCCGAGCCCCCGGGGTCTCCACCGAGCTCTCCA
CCGCCTGCCTCCCTTGGGAGGCCGGAGGGAGAGGAGGAGGGGCCGGCCGAGCCCGAAGAG
CACTCGGTGAGGATCTGCATGAGCCCGGGCCCGGAGCCGGGAGAGCAGATCCTGTCGGTG
AAGATGCCGGAGGAAAGGGAGGAGAAGGCGGAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1251 |
| Molecular Weight
| 139676.6 |
| Theoretical pI
| 4.46 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["657-675", "690-708", "734-753", "791-813", "858-877", "962-982"]
|
| Protein Sequence
|
>Cyclic nucleotide-gated cation channel beta-1
MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFK
EEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHS
ITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVW
RDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQ
AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQV
EPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEE
EEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEK
AKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLM
AEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSD
PTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKP
SPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWL
FFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGD
IITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLE
SILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAV
KTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDST
VKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKV
ALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLV
TLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKA
RRMLRSNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELA
ALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSP
PPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE
|
| External Links |
|---|
| GenBank ID Protein
| 114205399 |
| UniProtKB/Swiss-Prot ID
| Q14028 |
| UniProtKB/Swiss-Prot Entry Name
| CNGB1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001297.4 |
| GeneCard ID
| CNGB1 |
| GenAtlas ID
| CNGB1 |
| HGNC ID
| HGNC:2151 |
| References |
|---|
| General References
| Not Available |