| Identification |
|---|
| HMDB Protein ID
| CDBP04799 |
| Secondary Accession Numbers
| Not Available |
| Name
| Choline transporter-like protein 2 |
| Description
| Not Available |
| Synonyms
|
- Solute carrier family 44 member 2
|
| Gene Name
| SLC44A2 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in choline transmembrane transporter activity |
| Specific Function
| Isoform 1, but not isoform 3, exhibits some choline transporter activity.
|
| GO Classification
|
| Biological Process |
| phosphatidylcholine biosynthetic process |
| positive regulation of I-kappaB kinase/NF-kappaB cascade |
| Cellular Component |
| integral to membrane |
| plasma membrane |
| Molecular Function |
| signal transducer activity |
| choline transmembrane transporter activity |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Sarcosine Oncometabolite Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19p13.1 |
| SNPs
| SLC44A2 |
| Gene Sequence
|
>2121 bp
ATGGGGGACGAGCGGCCCCACTACTACGGGAAACACGGAACGCCACAGAAGTATGATCCC
ACTTTCAAAGGACCCATTTACAATAGGGGCTGCACGGATATCATATGCTGTGTGTTCCTG
CTCCTGGCCATTGTGGGCTACGTGGCTGTAGGCATCATAGCCTGGACTCATGGAGACCCT
CGAAAGGTGATCTACCCCACTGATAGCCGGGGCGAGTTCTGCGGGCAGAAGGGCACAAAA
AACGAGAACAAACCCTATCTGTTTTATTTCAACATTGTGAAATGTGCCAGCCCCCTGGTT
CTGCTGGAATTCCAATGTCCCACTCCCCAGATCTGCGTGGAAAAATGCCCCGACCGCTAC
CTCACGTACCTGAATGCTCGCAGCTCCCGGGACTTTGAGTACTATAAGCAGTTCTGTGTT
CCTGGCTTCAAGAACAATAAAGGAGTGGCTGAGGTGCTTCGAGATGGTGACTGCCCTGCT
GTCCTCATCCCCAGCAAACCCTTGGCCCGGAGATGCTTCCCCGCTATCCACGCCTACAAG
GGTGTCCTGATGGTGGGCAATGAGACGACCTATGAGGATGGGCATGGCTCCCGGAAAAAC
ATCACAGACCTGGTGGAGGGCGCCAAGAAAGCCAATGGAGTCCTAGAGGCGCGGCAACTC
GCCATGCGCATATTTGAAGATTACACCGTCTCTTGGTACTGGATTATCATAGGCCTGGTC
ATTGCCATGGCGATGAGCCTCCTGTTCATCATCCTGCTTCGCTTCCTGGCTGGTATTATG
GTCTGGGTGATGATCATCATGGTGATTCTGGTGCTGGGCTACGGAATATTTCACTGCTAC
ATGGAGTACTCCCGACTGCGTGGTGAGGCCGGCTCTGATGTCTCTTTGGTGGACCTCGGC
TTTCAGACGGATTTCCGGGTGTACCTGCACTTACGGCAGACCTGGTTGGCCTTTATGATC
ATTCTGAGTATCCTTGAAGTCATTATCATCTTGCTGCTCATCTTTCTCCGGAAGAGAATT
CTCATCGCGATTGCACTCATCAAAGAAGCCAGCAGGGCTGTGGGATACGTCATGTGCTCC
TTGCTCTACCCACTGGTCACCTTCTTCTTGCTGTGCCTCTGCATCGCCTACTGGGCCAGC
ACTGCTGTCTTCCTGTCCACTTCCAACGAAGCGGTCTATAAGATCTTTGATGACAGCCCC
TGCCCATTTACTGCGAAAACCTGCAACCCAGAGACCTTCCCCTCCTCCAATGAGTCCCGC
CAATGCCCCAATGCCCGTTGCCAGTTCGCCTTCTACGGTGGTGAGTCGGGCTACCACCGG
GCCCTGCTGGGCCTGCAGATCTTCAATGCCTTCATGTTCTTCTGGTTGGCCAACTTCGTG
CTGGCGCTGGGCCAGGTCACGCTGGCCGGGGCCTTTGCCTCCTATTACTGGGCCCTGCGC
AAGCCGGACGACCTGCCGGCCTTCCCGCTCTTCTCTGCCTTTGGCCGGGCGCTCAGGTAC
CACACAGGCTCCCTGGCCTTTGGNGCGCTCATCCTGGCCATTGTGCAGATCATCCGTGTG
ATACTCGAGTACCTGGATCAGCGGCTGAAAGGTGCAGAGAACAAGTTTGCCAAGTGCCTC
ATGACCTGTCTCAAATGCTGCTTCTGGTGCCTGGAGAAGTTCATCAAATTCCTTAATAGG
AATGCCTACATCATGATTGCCATCTACGGCACCAATTTCTGCACCTCGGCCAGGAATGCC
TTCTTCCTGCTCATGAGAAACATCATCAGAGTGGCTGTCCTGGATAAAGTTACTGACTTC
CTCTTCCTGTTGGGCAAACTTCTGATCGTTGGTAGTGTGGGGATCCTGGCTTTCTTCTTC
TTCACCCACCGTATCAGGATCGTGCAGGATACAGCACCACCCCTCAATTATTACTGGGTT
CCTATACTGACGGTGATCGTTGGCTCCTACTTGATTGCACACGGTTTCTTCAGCGTCTAT
GGCATGTGTGTGGACACGCTGTTCCTCTGCTTCTTGGAGGACCTGGAGAGGAATGACGGC
TCGGCCGAGAGGCCTTACTTCATGTCTTCCACCCTCAAGAAACTCTTGAACAAGACCAAC
AAGAAGGCAGCGGAGTCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 706 |
| Molecular Weight
| 79845.355 |
| Theoretical pI
| 8.53 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Choline transporter-like protein 2
MGDERPHYYGKHGTPQKYDPTFKGPIYNRGCTDIICCVFLLLAIVGYVAVGIIAWTHGDP
RKVIYPTDSRGEFCGQKGTKNENKPYLFYFNIVKCASPLVLLEFQCPTPQICVEKCPDRY
LTYLNARSSRDFEYYKQFCVPGFKNNKGVAEVLRDGDCPAVLIPSKPLARRCFPAIHAYK
GVLMVGNETTYEDGHGSRKNITDLVEGAKKANGVLEARQLAMRIFEDYTVSWYWIIIGLV
IAMAMSLLFIILLRFLAGIMVWVMIIMVILVLGYGIFHCYMEYSRLRGEAGSDVSLVDLG
FQTDFRVYLHLRQTWLAFMIILSILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCS
LLYPLVTFFLLCLCIAYWASTAVFLSTSNEAVYKIFDDSPCPFTAKTCNPETFPSSNESR
QCPNARCQFAFYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALR
KPDDLPAFPLFSAFGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAENKFAKCL
MTCLKCCFWCLEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDF
LFLLGKLLIVGSVGILAFFFFTHRIRIVQDTAPPLNYYWVPILTVIVGSYLIAHGFFSVY
GMCVDTLFLCFLEDLERNDGSAERPYFMSSTLKKLLNKTNKKAAES
|
| External Links |
|---|
| GenBank ID Protein
| 6996444 |
| UniProtKB/Swiss-Prot ID
| Q8IWA5 |
| UniProtKB/Swiss-Prot Entry Name
| CTL2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ245621 |
| GeneCard ID
| SLC44A2 |
| GenAtlas ID
| SLC44A2 |
| HGNC ID
| HGNC:17292 |
| References |
|---|
| General References
| Not Available |