| Identification |
|---|
| HMDB Protein ID
| CDBP04773 |
| Secondary Accession Numbers
| Not Available |
| Name
| CUGBP Elav-like family member 2 |
| Description
| Not Available |
| Synonyms
|
- Bruno-like protein 3
- CELF-2
- CUG triplet repeat RNA-binding protein 2
- CUG-BP- and ETR-3-like factor 2
- CUG-BP2
- ELAV-type RNA-binding protein 3
- ETR-3
- Neuroblastoma apoptosis-related RNA-binding protein
- RNA-binding protein BRUNOL-3
- hNAPOR
|
| Gene Name
| CELF2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleotide binding |
| Specific Function
| RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons:promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre- mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing. Binds to (CUG)n repeats |
| GO Classification
|
| Function |
| binding |
| nucleotide binding |
| nucleic acid binding |
| rna binding |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10p13 |
| SNPs
| CELF2 |
| Gene Sequence
|
>1527 bp
ATGCGCTGTCCCAAATCCGCTGTTACTATGAGAAATGAAGAGCTGCTTTTAAGTAACGGC
ACAGCCAACAAGATGAACGGAGCTTTGGATCACTCAGACCAACCAGACCCAGATGCCATT
AAGATGTTTGTCGGACAGATCCCCCGGTCATGGTCGGAAAAGGAGCTGAAAGAACTTTTT
GAGCCTTACGGAGCCGTCTACCAGATCAACGTCCTCCGGGACCGGAGTCAGAACCCTCCG
CAGAGTAAAGGTTGTTGTTTCGTAACATTTTATACAAGAAAAGCTGCACTTGAGGCCCAG
AATGCACTGCACAATATTAAAACTTTACCTGGGATGCATCATCCCATTCAGATGAAACCT
GCAGATAGTGAAAAGTCCAACGCTGTGGAAGACAGAAAATTGTTCATAGGAATGGTATCG
AAGAAATGTAATGAGAACGACATCAGGGTGATGTTCTCTCCATTTGGCCAGATAGAAGAA
TGCCGGATCCTCCGGGGACCTGATGGGCTGAGTCGAGGCTGTGCGTTTGTCACATTTTCT
ACAAGGGCAATGGCACAGAATGCAATCAAAGCCATGCATCAGTCTCAGACCATGGAGGGC
TGCTCTTCACCTATCGTGGTGAAGTTTGCTGACACTCAGAAGGACAAAGAGCAAAGGCGC
CTCCAGCAGCAGCTCGCTCAGCAGATGCAGCAGCTCAACACTGCCACCTGGGGGAACCTG
ACAGGGCTGGGCGGACTGACCCCACAGTATCTGGCGCTCCTGCAGCAGGCCACCTCCTCC
AGCAACCTGGGTGCGTTCAGCGGCATTCAACAAATGGCAGGCATGAATGCTTTACAGTTG
CAGAACCTGGCGACGCTGGCTGCTGCTGCAGCTGCGGCCCAGACCTCAGCCACCAGCACC
AATGCAAACCCTCTCTCTACCACGAGCAGCGCCCTGGGAGCCCTCACGAGTCCCGTGGCT
GCTTCAACCCCCAACTCCACTGCTGGTGCAGCCATGAACTCCTTGACCTCTCTCGGGACT
CTGCAAGGACTGGCTGGAGCCACTGTTGGACTGAATAATATTAATGCACTAGCAGGTATG
GCGGCTCTGAATGGAGGACTTGGCGCCACAGGCTTGACGAATGGCACGGCTGGCACCATG
GACGCCCTCACCCAGGCCTACTCAGGAATTCAACAGTACGCAGCCGCCGCGCTGCCCACT
CTGTACAGCCAGAGCCTGCTGCAGCAGCAGAGCGCTGCAGGCAGCCAGAAGGAAGGTCCA
GAGGGGGCAAACCTCTTTATTTACCACCTTCCACAGGAATTTGGAGACCAGGACATTCTG
CAGATGTTCATGCCTTTTGGAAATGTTATCTCTGCTAAAGTCTTCATTGACAAACAGACC
AATCTGAGCAAGTGCTTTGGTTTTGTTAGCTACGACAATCCAGTCTCTGCACAAGCTGCT
ATCCAAGCTATGAATGGCTTTCAGATCGGCATGAAACGCTTGAAGGTGCAGCTGAAGCGT
TCCAAAAACGACAGCAAACCTTACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 508 |
| Molecular Weight
| 54284.4 |
| Theoretical pI
| 9.01 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>CUGBP Elav-like family member 2
MRCPKSAVTMRNEELLLSNGTANKMNGALDHSDQPDPDAIKMFVGQIPRSWSEKELKELF
EPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNIKTLPGMHHPIQMKP
ADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFS
TRAMAQNAIKAMHQSQTMEGCSSPIVVKFADTQKDKEQRRLQQQLAQQMQQLNTATWGNL
TGLGGLTPQYLALLQQATSSSNLGAFSGIQQMAGMNALQLQNLATLAAAAAAAQTSATST
NANPLSTTSSALGALTSPVAASTPNSTAGAAMNSLTSLGTLQGLAGATVGLNNINALAGM
AALNGGLGATGLTNGTAGTMDALTQAYSGIQQYAAAALPTLYSQSLLQQQSAAGSQKEGP
EGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAA
IQAMNGFQIGMKRLKVQLKRSKNDSKPY
|
| External Links |
|---|
| GenBank ID Protein
| 68303647 |
| UniProtKB/Swiss-Prot ID
| O95319 |
| UniProtKB/Swiss-Prot Entry Name
| CELF2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001025077.2 |
| GeneCard ID
| CELF2 |
| GenAtlas ID
| CELF2 |
| HGNC ID
| HGNC:2550 |
| References |
|---|
| General References
| Not Available |